264 related articles for article (PubMed ID: 7710944)
1. Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations.
Khan S; O'Brien PJ
Br J Cancer; 1995 Apr; 71(4):780-5. PubMed ID: 7710944
[TBL] [Abstract][Full Text] [Related]
2. Molecular mechanisms of SR 4233-induced hepatocyte toxicity under aerobic versus hypoxic conditions.
Silva JM; O'Brien PJ
Br J Cancer; 1993 Sep; 68(3):484-91. PubMed ID: 8394729
[TBL] [Abstract][Full Text] [Related]
3. Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075).
Riley RJ; Hemingway SA; Graham MA; Workman P
Biochem Pharmacol; 1993 Mar; 45(5):1065-77. PubMed ID: 8461036
[TBL] [Abstract][Full Text] [Related]
4. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
Fourie J; Oleschuk CJ; Guziec F; Guziec L; Fiterman DJ; Monterrosa C; Begleiter A
Cancer Chemother Pharmacol; 2002 Feb; 49(2):101-10. PubMed ID: 11862423
[TBL] [Abstract][Full Text] [Related]
5. Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity.
Elwell JH; Siim BG; Evans JW; Brown JM
Biochem Pharmacol; 1997 Jul; 54(2):249-57. PubMed ID: 9271329
[TBL] [Abstract][Full Text] [Related]
6. Biological reactive intermediates that mediate chromium (VI) toxicity.
Pourahmad J; O'Brien PJ
Adv Exp Med Biol; 2001; 500():203-7. PubMed ID: 11764936
[TBL] [Abstract][Full Text] [Related]
7. Modulation of trenimon-induced cytotoxicity by DT-diaphorase in isolated rat hepatocytes under aerobic versus hypoxic conditions.
Silva JM; Rao DN; O'Brien PJ
Cancer Res; 1992 Jun; 52(11):3015-21. PubMed ID: 1375532
[TBL] [Abstract][Full Text] [Related]
8. A search for cellular and molecular mechanisms involved in depleted uranium (DU) toxicity.
Pourahmad J; Ghashang M; Ettehadi HA; Ghalandari R
Environ Toxicol; 2006 Aug; 21(4):349-54. PubMed ID: 16841314
[TBL] [Abstract][Full Text] [Related]
9. Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.
Walton MI; Workman P
Biochem Pharmacol; 1990 Jun; 39(11):1735-42. PubMed ID: 2344370
[TBL] [Abstract][Full Text] [Related]
10. Modulating hypoxia-induced hepatocyte injury by affecting intracellular redox state.
Khan S; O'Brien PJ
Biochim Biophys Acta; 1995 Nov; 1269(2):153-61. PubMed ID: 7488648
[TBL] [Abstract][Full Text] [Related]
11. Hepatocyte injury resulting from the inhibition of mitochondrial respiration at low oxygen concentrations involves reductive stress and oxygen activation.
Niknahad H; Khan S; O'Brien PJ
Chem Biol Interact; 1995 Oct; 98(1):27-44. PubMed ID: 7586049
[TBL] [Abstract][Full Text] [Related]
12. Metabolic activation of 3-hydroxyanisole by isolated rat hepatocytes.
Moridani MY; Cheon SS; Khan S; O'Brien PJ
Chem Biol Interact; 2003 Jan; 142(3):317-33. PubMed ID: 12453669
[TBL] [Abstract][Full Text] [Related]
13. DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.
Plumb JA; Gerritsen M; Workman P
Br J Cancer; 1994 Dec; 70(6):1136-43. PubMed ID: 7526885
[TBL] [Abstract][Full Text] [Related]
14. Phenylenediamine induced hepatocyte cytotoxicity redox. Cycling mediated oxidative stress without oxygen activation.
Sood C; Khan S; O'Brien PJ
Biochim Biophys Acta; 1997 Jun; 1335(3):343-52. PubMed ID: 9202197
[TBL] [Abstract][Full Text] [Related]
15. Protection against SR 4233 (Tirapazamine) aerobic cytotoxicity by the metal chelators desferrioxamine and tiron.
Herscher LL; Krishna MC; Cook JA; Coleman CN; Biaglow JE; Tuttle SW; Gonzalez FJ; Mitchell JB
Int J Radiat Oncol Biol Phys; 1994 Nov; 30(4):879-85. PubMed ID: 7960991
[TBL] [Abstract][Full Text] [Related]
16. Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes.
Siraki AG; Pourahmad J; Chan TS; Khan S; O'Brien PJ
Free Radic Biol Med; 2002 Jan; 32(1):2-10. PubMed ID: 11755311
[TBL] [Abstract][Full Text] [Related]
17. Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells.
Riley RJ; Workman P
Biochem Pharmacol; 1992 Jan; 43(2):167-74. PubMed ID: 1739405
[TBL] [Abstract][Full Text] [Related]
18. Lysosomal oxidative stress cytotoxicity induced by nitrofurantoin redox cycling in hepatocytes.
Pourahmad J; Khan S; O'Brien PJ
Adv Exp Med Biol; 2001; 500():261-5. PubMed ID: 11764951
[TBL] [Abstract][Full Text] [Related]
19. Cytochrome P450 2E1 metabolically activates propargyl alcohol: propiolaldehyde-induced hepatocyte cytotoxicity.
Moridani MY; Khan S; Chan T; Teng S; Beard K; O'Brien PJ
Chem Biol Interact; 2001 Jan; 130-132(1-3):931-42. PubMed ID: 11306107
[TBL] [Abstract][Full Text] [Related]
20. Role of cytochrome P-450IIE1 in N-nitroso-N-methylaniline induced hepatocyte cytotoxicity.
Quan Z; Khan S; O'Brien PJ
Chem Biol Interact; 1992 Aug; 83(3):221-33. PubMed ID: 1516150
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
