120 related articles for article (PubMed ID: 7712126)
1. Renin inhibitor SC-51106 complexed with human renin: discovery of a new binding site adjacent to P3.
Hanson GJ; Clare M; Summers NL; Lim LW; Neidhart DJ; Shieh HS; Stevens AM
Bioorg Med Chem; 1994 Sep; 2(9):909-18. PubMed ID: 7712126
[TBL] [Abstract][Full Text] [Related]
2. Synthesis and structure-activity relationships of human renin inhibitors designed from angiotensinogen transition state.
Iizuka K; Kamijo T; Harada H; Akahane K; Kubota T; Etoh Y; Shimaoka I; Tsubaki A; Murakami M; Yamaguchi T
Chem Pharm Bull (Tokyo); 1990 Sep; 38(9):2487-93. PubMed ID: 2285979
[TBL] [Abstract][Full Text] [Related]
3. Orally potent human renin inhibitors derived from angiotensinogen transition state: design, synthesis, and mode of interaction.
Iizuka K; Kamijo T; Harada H; Akahane K; Kubota T; Umeyama H; Ishida T; Kiso Y
J Med Chem; 1990 Oct; 33(10):2707-14. PubMed ID: 2120440
[TBL] [Abstract][Full Text] [Related]
4. Discovery of highly potent renin inhibitors potentially interacting with the S3' subsite of renin.
Sun X; Wen X; Chen YY; Shi C; Gao C; Wu Y; Wang LJ; Yang XH; Sun H
Eur J Med Chem; 2015 Oct; 103():269-88. PubMed ID: 26363506
[TBL] [Abstract][Full Text] [Related]
5. X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen.
Dealwis CG; Frazao C; Badasso M; Cooper JB; Tickle IJ; Driessen H; Blundell TL; Murakami K; Miyazaki H; Sueiras-Diaz J
J Mol Biol; 1994 Feb; 236(1):342-60. PubMed ID: 8107115
[TBL] [Abstract][Full Text] [Related]
6. Structure-based drug design: the discovery of novel nonpeptide orally active inhibitors of human renin.
Rahuel J; Rasetti V; Maibaum J; Rüeger H; Göschke R; Cohen NC; Stutz S; Cumin F; Fuhrer W; Wood JM; Grütter MG
Chem Biol; 2000 Jul; 7(7):493-504. PubMed ID: 10903938
[TBL] [Abstract][Full Text] [Related]
7. Design and synthesis of renin inhibitors: incorporation of transition-state isostere side chains that span from the S1 to the S3 binding pockets and examination of P3-modified renin inhibitors.
Plummer MS; Shahripour A; Kaltenbronn JS; Lunney EA; Steinbaugh BA; Hamby JM; Hamilton HW; Sawyer TK; Humblet C; Doherty AM
J Med Chem; 1995 Jul; 38(15):2893-905. PubMed ID: 7636850
[TBL] [Abstract][Full Text] [Related]
8. Novel approach of fragment-based lead discovery applied to renin inhibitors.
Tawada M; Suzuki S; Imaeda Y; Oki H; Snell G; Behnke CA; Kondo M; Tarui N; Tanaka T; Kuroita T; Tomimoto M
Bioorg Med Chem; 2016 Nov; 24(22):6066-6074. PubMed ID: 27720325
[TBL] [Abstract][Full Text] [Related]
9. Thermodynamics of the interaction of inhibitors with the binding site of recombinant human renin.
Epps DE; Cheney J; Schostarez H; Sawyer TK; Prairie M; Krueger WC; Mandel F
J Med Chem; 1990 Aug; 33(8):2080-6. PubMed ID: 2197411
[TBL] [Abstract][Full Text] [Related]
10. Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.
Lunney EA; Hamilton HW; Hodges JC; Kaltenbronn JS; Repine JT; Badasso M; Cooper JB; Dealwis C; Wallace BA; Lowther WT
J Med Chem; 1993 Nov; 36(24):3809-20. PubMed ID: 8254610
[TBL] [Abstract][Full Text] [Related]
11. High resolution crystal structures of recombinant human renin in complex with polyhydroxymonoamide inhibitors.
Tong L; Pav S; Lamarre D; Pilote L; LaPlante S; Anderson PC; Jung G
J Mol Biol; 1995 Jul; 250(2):211-22. PubMed ID: 7608971
[TBL] [Abstract][Full Text] [Related]
12. Roles of His9 (P2 subsite) and His13 (P3' subsite) in angiotensinogen for catalytic reaction of renin.
Nabi AH; Uddin MN; Nakagawa T; Orihashi T; Ebihara A; Iwasawa A; Nakamura Y; Suzuki F
Int J Mol Med; 2005 Jul; 16(1):103-7. PubMed ID: 15942685
[TBL] [Abstract][Full Text] [Related]
13. Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension.
Chen A; Bayly C; Bezençon O; Richard-Bildstein S; Dubé D; Dubé L; Gagné S; Gallant M; Gaudreault M; Grimm E; Houle R; Lacombe P; Laliberté S; Lévesque JF; Liu S; MacDonald D; Mackay B; Martin D; McKay D; Powell D; Remen L; Soisson S; Toulmond S
Bioorg Med Chem Lett; 2010 Apr; 20(7):2204-9. PubMed ID: 20206513
[TBL] [Abstract][Full Text] [Related]
14. Exploiting the molecular template of angiotensinogen in the discovery and design of peptidyl, pseudopeptidyl and peptidimimetic inhibitors of human renin: a structure-activity perspective.
Sawyer TK; Hester JB; Schostarez HJ; Thaisrivongs S; Bundy GL; Liu L; Bradford VS; De Vaux AE; Staples DJ; Maggiora LL
Adv Exp Med Biol; 1991; 306():307-23. PubMed ID: 1812721
[No Abstract] [Full Text] [Related]
15. Rational design of 6-(2,4-diaminopyrimidinyl)-1,4-benzoxazin-3-ones as small molecule renin inhibitors.
Powell NA; Ciske FL; Cai C; Holsworth DD; Mennen K; Van Huis CA; Jalaie M; Day J; Mastronardi M; McConnell P; Mochalkin I; Zhang E; Ryan MJ; Bryant J; Collard W; Ferreira S; Gu C; Collins R; Edmunds JJ
Bioorg Med Chem; 2007 Sep; 15(17):5912-49. PubMed ID: 17574423
[TBL] [Abstract][Full Text] [Related]
16. X-ray analyses of peptide-inhibitor complexes define the structural basis of specificity for human and mouse renins.
Dhanaraj V; Dealwis CG; Frazao C; Badasso M; Sibanda BL; Tickle IJ; Cooper JB; Driessen HP; Newman M; Aguilar C
Nature; 1992 Jun; 357(6378):466-72. PubMed ID: 1608447
[TBL] [Abstract][Full Text] [Related]
17. The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor.
Rahuel J; Priestle JP; Grütter MG
J Struct Biol; 1991 Dec; 107(3):227-36. PubMed ID: 1807356
[TBL] [Abstract][Full Text] [Related]
18. Substrate specificity of human renin: the effect of substitutions at the amino terminus and P3 position of the substrate.
Green DW; Rivetna MN
Adv Exp Med Biol; 1991; 306():383-6. PubMed ID: 1812732
[No Abstract] [Full Text] [Related]
19. The power of visual imagery in synthesis planning. Stereocontrolled approaches to CGP-60536B, a potent renin inhibitor.
Hanessian S; Claridge S; Johnstone S
J Org Chem; 2002 Jun; 67(12):4261-74. PubMed ID: 12054962
[TBL] [Abstract][Full Text] [Related]
20. The discovery of novel potent trans-3,4-disubstituted pyrrolidine inhibitors of the human aspartic protease renin from in silico three-dimensional (3D) pharmacophore searches.
Lorthiois E; Breitenstein W; Cumin F; Ehrhardt C; Francotte E; Jacoby E; Ostermann N; Sellner H; Kosaka T; Webb RL; Rigel DF; Hassiepen U; Richert P; Wagner T; Maibaum J
J Med Chem; 2013 Mar; 56(6):2207-17. PubMed ID: 23425156
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
