BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

149 related articles for article (PubMed ID: 7713916)

  • 1. Expression, characterization, and crystallization of the catalytic core of the human insulin receptor protein-tyrosine kinase domain.
    Wei L; Hubbard SR; Hendrickson WA; Ellis L
    J Biol Chem; 1995 Apr; 270(14):8122-30. PubMed ID: 7713916
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis, purification, and characterization of the cytoplasmic domain of the human insulin receptor using a baculovirus expression system.
    Herrera R; Lebwohl D; Garcia de Herreros A; Kallen RG; Rosen OM
    J Biol Chem; 1988 Apr; 263(12):5560-8. PubMed ID: 2451671
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cis-autophosphorylation of juxtamembrane tyrosines in the insulin receptor kinase domain.
    Cann AD; Kohanski RA
    Biochemistry; 1997 Jun; 36(25):7681-9. PubMed ID: 9201908
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Autophosphorylation of the two C-terminal tyrosine residues Tyr1316 and Tyr1322 modulates the activity of the insulin receptor kinase in vitro.
    Tennagels N; Bergschneider E; Al-Hasani H; Klein HW
    FEBS Lett; 2000 Aug; 479(1-2):67-71. PubMed ID: 10940390
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Human insulin receptor beta-subunit transmembrane/cytoplasmic domain expressed in a baculovirus expression system: purification, characterization, and polylysine effects on the protein tyrosine kinase activity.
    Li SL; Yan PF; Paz IB; Fujita-Yamaguchi Y
    Biochemistry; 1992 Dec; 31(49):12455-62. PubMed ID: 1334428
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Two-dimensional phosphopeptide analysis of the autophosphorylation cascade of a soluble insulin receptor tyrosine kinase. The tyrosines phosphorylated are typical of those observed following phosphorylation of the heterotetrameric insulin receptor in intact cells.
    Tavaré JM; Clack B; Ellis L
    J Biol Chem; 1991 Jan; 266(3):1390-5. PubMed ID: 1703148
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Insulin receptor kinase domain autophosphorylation regulates receptor enzymatic function.
    Wilden PA; Kahn CR; Siddle K; White MF
    J Biol Chem; 1992 Aug; 267(23):16660-8. PubMed ID: 1322912
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The insulin and IGF1 receptor kinase domains are functional dimers in the activated state.
    Cabail MZ; Li S; Lemmon E; Bowen ME; Hubbard SR; Miller WT
    Nat Commun; 2015 Mar; 6():6406. PubMed ID: 25758790
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Enhanced insulin-induced mitogenesis and mitogen-activated protein kinase activities in mutant insulin receptors with substitution of two COOH-terminal tyrosine autophosphorylation sites by phenylalanine.
    Ando A; Momomura K; Tobe K; Yamamoto-Honda R; Sakura H; Tamori Y; Kaburagi Y; Koshio O; Akanuma Y; Yazaki Y
    J Biol Chem; 1992 Jun; 267(18):12788-96. PubMed ID: 1618780
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor.
    Li S; Covino ND; Stein EG; Till JH; Hubbard SR
    J Biol Chem; 2003 Jul; 278(28):26007-14. PubMed ID: 12707268
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Amino acid sequences Gly-Pro-Leu-Tyr and Asn-Pro-Glu-Tyr in the submembranous domain of the insulin receptor are required for normal endocytosis.
    Rajagopalan M; Neidigh JL; McClain DA
    J Biol Chem; 1991 Dec; 266(34):23068-73. PubMed ID: 1744103
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Autophosphorylation induces autoactivation and a decrease in the Src homology 2 domain accessibility of the Lyn protein kinase.
    Sotirellis N; Johnson TM; Hibbs ML; Stanley IJ; Stanley E; Dunn AR; Cheng HC
    J Biol Chem; 1995 Dec; 270(50):29773-80. PubMed ID: 8530369
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Two sequences flanking the major autophosphorylation site of the insulin receptor are essential for tyrosine kinase activation.
    Leconte I; Clauser E
    Biochem J; 1995 Mar; 306 ( Pt 2)(Pt 2):465-72. PubMed ID: 7887900
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Kinase inhibition by a phosphorylated peptide corresponding to the major insulin receptor autophosphorylation domain.
    Chavanieu A; Calas B; Vaglio P; Grigorescu F
    Eur J Biochem; 1992 Sep; 208(2):367-73. PubMed ID: 1381676
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Autophosphorylation of the Fes tyrosine kinase. Evidence for an intermolecular mechanism involving two kinase domain tyrosine residues.
    Rogers JA; Read RD; Li J; Peters KL; Smithgall TE
    J Biol Chem; 1996 Jul; 271(29):17519-25. PubMed ID: 8663427
    [TBL] [Abstract][Full Text] [Related]  

  • 16. C-terminus or juxtamembrane deletions in the insulin receptor do not affect the glucose-dependent inhibition of the tyrosine kinase activity.
    Mosthaf L; Berti L; Kellerer M; Mushack J; Seffer E; Bossenmaier B; Coghlan M; Siddle K; Ullrich A; Häring HU
    Eur J Biochem; 1995 Feb; 227(3):787-91. PubMed ID: 7867639
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Serine residues 1177/78/82 of the insulin receptor are required for substrate phosphorylation but not autophosphorylation.
    Bossenmaier B; Strack V; Stoyanov B; Krützfeldt J; Beck A; Lehmann R; Kellerer M; Klein H; Ullrich A; Lammers R; Häring HU
    Diabetes; 2000 Jun; 49(6):889-95. PubMed ID: 10866039
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Replacement of the conserved tyrosine 1210 by phenylalanine in the insulin receptor affects insulin-induced dephosphorylation of focal adhesion kinase but leaves other responses intact.
    Van der Zon GC; Ouwens DM; Dorrestijn J; Maassen JA
    Biochemistry; 1996 Aug; 35(32):10377-82. PubMed ID: 8756693
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity.
    Choi S; Park S
    Oncogene; 1999 Sep; 18(39):5413-22. PubMed ID: 10498895
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase.
    Ling L; Templeton D; Kung HJ
    J Biol Chem; 1996 Aug; 271(31):18355-62. PubMed ID: 8702477
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.