170 related articles for article (PubMed ID: 7728943)
1. The deuterium isotope effect for the alpha-hydroxylation of tamoxifen by rat liver microsomes accounts for the reduced genotoxicity of [D5-ethyl]tamoxifen.
Jarman M; Poon GK; Rowlands MG; Grimshaw RM; Horton MN; Potter GA; McCague R
Carcinogenesis; 1995 Apr; 16(4):683-8. PubMed ID: 7728943
[TBL] [Abstract][Full Text] [Related]
2. Reduced genotoxicity of [D5-ethyl]-tamoxifen implicates alpha-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen.
Phillips DH; Potter GA; Horton MN; Hewer A; Crofton-Sleigh C; Jarman M; Venitt S
Carcinogenesis; 1994 Aug; 15(8):1487-92. PubMed ID: 8055624
[TBL] [Abstract][Full Text] [Related]
3. N-demethylation accompanies alpha-hydroxylation in the metabolic activation of tamoxifen in rat liver cells.
Phillips DH; Hewer A; Horton MN; Cole KJ; Carmichael PL; Davis W; Osborne MR
Carcinogenesis; 1999 Oct; 20(10):2003-9. PubMed ID: 10506117
[TBL] [Abstract][Full Text] [Related]
4. Major inter-species differences in the rates of O-sulphonation and O-glucuronylation of alpha-hydroxytamoxifen in vitro: a metabolic disparity protecting human liver from the formation of tamoxifen-DNA adducts.
Boocock DJ; Maggs JL; Brown K; White IN; Park BK
Carcinogenesis; 2000 Oct; 21(10):1851-8. PubMed ID: 11023543
[TBL] [Abstract][Full Text] [Related]
5. A comparative study of tamoxifen metabolism in female rat, mouse and human liver microsomes.
Lim CK; Yuan ZX; Lamb JH; White IN; De Matteis F; Smith LL
Carcinogenesis; 1994 Apr; 15(4):589-93. PubMed ID: 8149466
[TBL] [Abstract][Full Text] [Related]
6. Identification and mechanism of formation of potentially genotoxic metabolites of tamoxifen: study by LC-MS/MS.
Lim CK; Yuan ZX; Jones RM; White IN; Smith LL
J Pharm Biomed Anal; 1997 Jun; 15(9-10):1335-42. PubMed ID: 9226561
[TBL] [Abstract][Full Text] [Related]
7. Tamoxifen metabolism in rat liver microsomes: identification of a dimeric metabolite derived from free radical intermediates by liquid chromatography/mass spectrometry.
Jones RM; Yuan ZX; Lim CK
Rapid Commun Mass Spectrom; 1999; 13(4):211-5. PubMed ID: 10097399
[TBL] [Abstract][Full Text] [Related]
8. On-line high-performance liquid chromatographic-electrospray ionization mass spectrometric method for the study of tamoxifen metabolism.
Jones RM; Yuan ZX; Lamb JH; Lim CK
J Chromatogr A; 1996 Jan; 722(1-2):249-55. PubMed ID: 9019299
[TBL] [Abstract][Full Text] [Related]
9. Alpha-hydroxytamoxifen, a genotoxic metabolite of tamoxifen in the rat: identification and quantification in vivo and in vitro.
Boocock DJ; Maggs JL; White IN; Park BK
Carcinogenesis; 1999 Jan; 20(1):153-60. PubMed ID: 9934863
[TBL] [Abstract][Full Text] [Related]
10. DNA adduct formation and mutant induction in Sprague-Dawley rats treated with tamoxifen and its derivatives.
Gamboa da Costa G; McDaniel-Hamilton LP; Heflich RH; Marques MM; Beland FA
Carcinogenesis; 2001 Aug; 22(8):1307-15. PubMed ID: 11470763
[TBL] [Abstract][Full Text] [Related]
11. Differences in metabolite-mediated toxicity of tamoxifen in rodents versus humans elucidated with DNA/microsome electro-optical arrays and nanoreactors.
Zhao L; Krishnan S; Zhang Y; Schenkman JB; Rusling JF
Chem Res Toxicol; 2009 Feb; 22(2):341-7. PubMed ID: 19166339
[TBL] [Abstract][Full Text] [Related]
12. Toremifene metabolism in rat, mouse and human liver microsomes: identification of alpha-hydroxytoremifene by LC-MS.
Jones RM; Lim CK
Biomed Chromatogr; 2002 Aug; 16(5):361-3. PubMed ID: 12210510
[TBL] [Abstract][Full Text] [Related]
13. Induction of tamoxifen-4-hydroxylation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), beta-naphthoflavone (beta NF), and phenobarbital (PB) in avian liver: identification of P450 TCDDAA as catalyst of 4-hydroxylation induced by TCDD and beta NF.
Kupfer D; Mani C; Lee CA; Rifkind AB
Cancer Res; 1994 Jun; 54(12):3140-4. PubMed ID: 8205532
[TBL] [Abstract][Full Text] [Related]
14. Analysis of phase I and phase II metabolites of tamoxifen in breast cancer patients.
Poon GK; Chui YC; McCague R; Lłnning PE; Feng R; Rowlands MG; Jarman M
Drug Metab Dispos; 1993; 21(6):1119-24. PubMed ID: 7905393
[TBL] [Abstract][Full Text] [Related]
15. Metabolism of the antimammary cancer antiestrogenic agent tamoxifen. I. Cytochrome P-450-catalyzed N-demethylation and 4-hydroxylation.
Mani C; Gelboin HV; Park SS; Pearce R; Parkinson A; Kupfer D
Drug Metab Dispos; 1993; 21(4):645-56. PubMed ID: 8104124
[TBL] [Abstract][Full Text] [Related]
16. Aspects of metabolism of tamoxifen by rat liver microsomes. Identification of a new metabolite: E-1-[4-(2-dimethylaminoethoxy)-phenyl]-1, 2-diphenyl-1-buten-3-ol N-oxide.
McCague R; Seago A
Biochem Pharmacol; 1986 Mar; 35(5):827-34. PubMed ID: 3954788
[TBL] [Abstract][Full Text] [Related]
17. Metabolism of olaquindox in rat liver microsomes: structural elucidation of metabolites by high-performance liquid chromatography combined with ion trap/time-of-flight mass spectrometry.
Liu Z; Huang L; Dai M; Chen D; Wang Y; Tao Y; Yuan Z
Rapid Commun Mass Spectrom; 2008 Apr; 22(7):1009-16. PubMed ID: 18320546
[TBL] [Abstract][Full Text] [Related]
18. Effect of N,N-didesmethyltamoxifen upon DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen.
Gamboa da Costa G; Marques MM; Fu X; Churchwell MI; Wang YP; Doerge DR; Beland FA
Cancer Lett; 2007 Nov; 257(2):191-8. PubMed ID: 17765393
[TBL] [Abstract][Full Text] [Related]
19. Validation of a novel in vitro assay using ultra performance liquid chromatography-mass spectrometry (UPLC/MS) to detect and quantify hydroxylated metabolites of BDE-99 in rat liver microsomes.
Erratico CA; Szeitz A; Bandiera SM
J Chromatogr B Analyt Technol Biomed Life Sci; 2010 Jun; 878(19):1562-8. PubMed ID: 20451473
[TBL] [Abstract][Full Text] [Related]
20. Quantification of tamoxifen DNA adducts using on-line sample preparation and HPLC-electrospray ionization tandem mass spectrometry.
Gamboa da Costa G; Marques MM; Beland FA; Freeman JP; Churchwell MI; Doerge DR
Chem Res Toxicol; 2003 Mar; 16(3):357-66. PubMed ID: 12641436
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
