126 related articles for article (PubMed ID: 7766395)
1. Comparative study of the inhibition of rat and tobacco squalene synthase by squalestatins.
Fulton DC; Tait M; Threlfall DR
Phytochemistry; 1995 Mar; 38(5):1137-41. PubMed ID: 7766395
[TBL] [Abstract][Full Text] [Related]
2. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
Dawson MJ; Farthing JE; Marshall PS; Middleton RF; O'Neill MJ; Shuttleworth A; Stylli C; Tait RM; Taylor PM; Wildman HG
J Antibiot (Tokyo); 1992 May; 45(5):639-47. PubMed ID: 1624366
[TBL] [Abstract][Full Text] [Related]
3. The squalestatins: novel inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C1-modified analogues.
Procopiou PA; Bailey EJ; Bamford MJ; Craven AP; Dymock BW; Houston JG; Hutson JL; Kirk BE; McCarthy AD; Sareen M
J Med Chem; 1994 Sep; 37(20):3274-81. PubMed ID: 7932554
[TBL] [Abstract][Full Text] [Related]
4. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. II. Structure elucidation.
Sidebottom PJ; Highcock RM; Lane SJ; Procopiou PA; Watson NS
J Antibiot (Tokyo); 1992 May; 45(5):648-58. PubMed ID: 1624367
[TBL] [Abstract][Full Text] [Related]
5. The squalestatins: synthesis and biological activity of some C3-modified analogues; replacement of a carboxylic acid or methyl ester with an isoelectronic heterocyclic functionality.
Bamford MJ; Chan C; Craven AP; Dymock BW; Green D; Henson RA; Kirk BE; Lester MG; Procopiou PA; Snowden MA
J Med Chem; 1995 Sep; 38(18):3502-13. PubMed ID: 7658437
[TBL] [Abstract][Full Text] [Related]
6. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. IV. Preparation of fluorinated squalestatins by directed biosynthesis.
Cannell RJ; Dawson MJ; Hale RS; Hall RM; Noble D; Lynn S; Taylor NL
J Antibiot (Tokyo); 1993 Sep; 46(9):1381-9. PubMed ID: 8226317
[TBL] [Abstract][Full Text] [Related]
7. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. III. Biosynthesis.
Jones CA; Sidebottom PJ; Cannell RJ; Noble D; Rudd BA
J Antibiot (Tokyo); 1992 Sep; 45(9):1492-8. PubMed ID: 1429235
[TBL] [Abstract][Full Text] [Related]
8. The squalestatins: decarboxy and 4-deoxy analogues as potent squalene synthase inhibitors.
Chan C; Andreotti D; Cox B; Dymock BW; Hutson JL; Keeling SE; McCarthy AD; Procopiou PA; Ross BC; Sareen M; Scicinski JJ; Sharratt PJ; Snowden MA; Watson NS
J Med Chem; 1996 Jan; 39(1):207-16. PubMed ID: 8568810
[TBL] [Abstract][Full Text] [Related]
9. Selective protection and relative importance of the carboxylic acid groups of zaragozic acid A for squalene synthase inhibition.
Biftu T; Acton JJ; Berger GD; Bergstrom JD; Dufresne C; Kurtz MM; Marquis RW; Parsons WH; Rew DR; Wilson KE
J Med Chem; 1994 Feb; 37(3):421-4. PubMed ID: 8308869
[TBL] [Abstract][Full Text] [Related]
10. The squalestatins: inhibitors of squalene synthase. Enzyme inhibitory activities and in vivo evaluation of C3-modified analogues.
Procopiou PA; Cox B; Kirk BE; Lester MG; McCarthy AD; Sareen M; Sharratt PJ; Snowden MA; Spooner SJ; Watson NS; Widdowson J
J Med Chem; 1996 Mar; 39(7):1413-22. PubMed ID: 8691471
[TBL] [Abstract][Full Text] [Related]
11. Competitive inhibition of squalene synthetase by squalestatin 1.
Hasumi K; Tachikawa K; Sakai K; Murakawa S; Yoshikawa N; Kumazawa S; Endo A
J Antibiot (Tokyo); 1993 Apr; 46(4):689-91. PubMed ID: 8501015
[No Abstract] [Full Text] [Related]
12. Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo.
Baxter A; Fitzgerald BJ; Hutson JL; McCarthy AD; Motteram JM; Ross BC; Sapra M; Snowden MA; Watson NS; Williams RJ
J Biol Chem; 1992 Jun; 267(17):11705-8. PubMed ID: 1601846
[TBL] [Abstract][Full Text] [Related]
13. Novel squalestatins produced by biotransformation.
Middleton RF; Foster G; Cannell RJ; Sidebottom PJ; Taylor NL; Noble D; Todd M; Dawson MJ; Lawrence GC
J Antibiot (Tokyo); 1995 Apr; 48(4):311-6. PubMed ID: 7775268
[TBL] [Abstract][Full Text] [Related]
14. Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase.
Dufresne C; Wilson KE; Singh SB; Zink DL; Bergstrom JD; Rew D; Polishook JD; Meinz M; Huang L; Silverman KC
J Nat Prod; 1993 Nov; 56(11):1923-9. PubMed ID: 8289063
[TBL] [Abstract][Full Text] [Related]
15. Production of additional squalestatin analogues by directed biosynthesis.
Cannell RJ; Dawson MJ; Hale RS; Hall RM; Noble D; Lynn S; Taylor NL
J Antibiot (Tokyo); 1994 Feb; 47(2):247-9. PubMed ID: 8150722
[No Abstract] [Full Text] [Related]
16. Selective inhibition of cholesterol biosynthesis in brain cells by squalestatin 1.
Crick DC; Suders J; Kluthe CM; Andres DA; Waechter CJ
J Neurochem; 1995 Sep; 65(3):1365-73. PubMed ID: 7643114
[TBL] [Abstract][Full Text] [Related]
17. Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase.
Ness GC; Zhao Z; Keller RK
Arch Biochem Biophys; 1994 Jun; 311(2):277-85. PubMed ID: 7911291
[TBL] [Abstract][Full Text] [Related]
18. Inhibition of mammalian squalene synthetase activity by zaragozic acid A is a result of competitive inhibition followed by mechanism-based irreversible inactivation.
Lindsey S; Harwood HJ
J Biol Chem; 1995 Apr; 270(16):9083-96. PubMed ID: 7721822
[TBL] [Abstract][Full Text] [Related]
19. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. V. Minor metabolites.
Blows WM; Foster G; Lane SJ; Noble D; Piercey JE; Sidebottom PJ; Webb G
J Antibiot (Tokyo); 1994 Jul; 47(7):740-54. PubMed ID: 8071119
[TBL] [Abstract][Full Text] [Related]
20. Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Ponpipom MM; Girotra NN; Bugianesi RL; Roberts CD; Berger GD; Burk RM; Marquis RW; Parsons WH; Bartizal KF; Bergstom JD
J Med Chem; 1994 Nov; 37(23):4031-51. PubMed ID: 7966163
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]