These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

307 related articles for article (PubMed ID: 7766621)

  • 1. Alteration of arginine-128 to alanine abolishes the ability of human O6-alkylguanine-DNA alkyltransferase to repair methylated DNA but has no effect on its reaction with O6-benzylguanine.
    Kanugula S; Goodtzova K; Edara S; Pegg AE
    Biochemistry; 1995 May; 34(21):7113-9. PubMed ID: 7766621
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Investigation of the role of tyrosine-114 in the activity of human O6-alkylguanine-DNA alkyltranferase.
    Goodtzova K; Kanugula S; Edara S; Pegg AE
    Biochemistry; 1998 Sep; 37(36):12489-95. PubMed ID: 9730821
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.
    Crone TM; Goodtzova K; Edara S; Pegg AE
    Cancer Res; 1994 Dec; 54(23):6221-7. PubMed ID: 7954470
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A single amino acid change in human O6-alkylguanine-DNA alkyltransferase decreasing sensitivity to inactivation by O6-benzylguanine.
    Crone TM; Pegg AE
    Cancer Res; 1993 Oct; 53(20):4750-3. PubMed ID: 8402653
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Conserved residue lysine165 is essential for the ability of O6-alkylguanine-DNA alkyltransferase to react with O6-benzylguanine.
    Xu-Welliver M; Kanugula S; Loktionova NA; Crone TM; Pegg AE
    Biochem J; 2000 Apr; 347(Pt 2):527-34. PubMed ID: 10749683
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Depletion of O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine in three-dimensional collagen cultures of normal human breast epithelial cells.
    Hamdan MA; Guzman RC; Yang J; Beattie C; Mascharack P; Nandi S
    Carcinogenesis; 1992 Oct; 13(10):1743-9. PubMed ID: 1423833
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase.
    Crone TM; Goodtzova K; Pegg AE
    Mutat Res; 1996 May; 363(1):15-25. PubMed ID: 8632775
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Resistance of the human O6-alkylguanine-DNA alkyltransferase containing arginine at codon 160 to inactivation by O6-benzylguanine.
    Edara S; Kanugula S; Goodtzova K; Pegg AE
    Cancer Res; 1996 Dec; 56(24):5571-5. PubMed ID: 8971155
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Alteration of the conserved residue tyrosine-158 to histidine renders human O6-alkylguanine-DNA alkyltransferase insensitive to the inhibitor O6-benzylguanine.
    Xu-Welliver M; Leitão J; Kanugula S; Pegg AE
    Cancer Res; 1999 Apr; 59(7):1514-9. PubMed ID: 10197622
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Expression of the inactive C145A mutant human O6-alkylguanine-DNA alkyltransferase in E.coli increases cell killing and mutations by N-methyl-N'-nitro-N-nitrosoguanidine.
    Edara S; Kanugula S; Pegg AE
    Carcinogenesis; 1999 Jan; 20(1):103-8. PubMed ID: 9934856
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Repair of O6-benzylguanine by the Escherichia coli Ada and Ogt and the human O6-alkylguanine-DNA alkyltransferases.
    Goodtzova K; Kanugula S; Edara S; Pauly GT; Moschel RC; Pegg AE
    J Biol Chem; 1997 Mar; 272(13):8332-9. PubMed ID: 9079656
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanism of inactivation of human O6-alkylguanine-DNA alkyltransferase by O6-benzylguanine.
    Pegg AE; Boosalis M; Samson L; Moschel RC; Byers TL; Swenn K; Dolan ME
    Biochemistry; 1993 Nov; 32(45):11998-2006. PubMed ID: 8218276
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Activation of human O6-alkylguanine-DNA alkyltransferase by DNA.
    Goodtzova K; Crone TM; Pegg AE
    Biochemistry; 1994 Jul; 33(28):8385-90. PubMed ID: 8031773
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Point mutations in human O6-alkylguanine-DNA alkyltransferase prevent the sensitization by O6-benzylguanine to killing by N,N'-bis (2-chloroethyl)-N-nitrosourea.
    Loktionova NA; Pegg AE
    Cancer Res; 1996 Apr; 56(7):1578-83. PubMed ID: 8603405
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Reaction of O6-benzylguanine-resistant mutants of human O6-alkylguanine-DNA alkyltransferase with O6-benzylguanine in oligodeoxyribonucleotides.
    Pegg AE; Kanugula S; Edara S; Pauly GT; Moschel RC; Goodtzova K
    J Biol Chem; 1998 May; 273(18):10863-7. PubMed ID: 9556560
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The repair of the tobacco specific nitrosamine derived adduct O6-[4-Oxo-4-(3-pyridyl)butyl]guanine by O6-alkylguanine-DNA alkyltransferase variants.
    Mijal RS; Thomson NM; Fleischer NL; Pauly GT; Moschel RC; Kanugula S; Fang Q; Pegg AE; Peterson LA
    Chem Res Toxicol; 2004 Mar; 17(3):424-34. PubMed ID: 15025514
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Effect of O6-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl-N'-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts.
    Lukash LL; Boldt J; Pegg AE; Dolan ME; Maher VM; McCormick JJ
    Mutat Res; 1991; 250(1-2):397-409. PubMed ID: 1944354
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A novel, sensitive assay for O6-methyl- and O6-ethylguanine in DNA, based on repair by the enzyme O6-alkylguanine-DNA-alkyltransferase in competition with an oligonucleotide containing O6-methylguanine.
    Souliotis VL; Kyrtopoulos SA
    Cancer Res; 1989 Dec; 49(24 Pt 1):6997-7001. PubMed ID: 2684406
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pyridyloxobutyl DNA adducts inhibit the repair of O6-methylguanine.
    Peterson LA; Liu XK; Hecht SS
    Cancer Res; 1993 Jun; 53(12):2780-5. PubMed ID: 8504419
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Pyridyloxobutylation of guanine residues by 4-[(acetoxymethyl)nitrosamino]-1-(3-pyridyl)-1-butanone generates substrates of O6-alkylguanine-DNA alkyltransferase.
    Liu XK; Spratt TE; Murphy SE; Peterson LA
    Chem Res Toxicol; 1996 Sep; 9(6):949-53. PubMed ID: 8870981
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 16.