BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

213 related articles for article (PubMed ID: 7799946)

  • 1. A dominant-negative mutant of mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways.
    Sakaue M; Bowtell D; Kasuga M
    Mol Cell Biol; 1995 Jan; 15(1):379-88. PubMed ID: 7799946
    [TBL] [Abstract][Full Text] [Related]  

  • 2. SOS phosphorylation and disassociation of the Grb2-SOS complex by the ERK and JNK signaling pathways.
    Dong Chen ; Waters SB; Holt KH; Pessin JE
    J Biol Chem; 1996 Mar; 271(11):6328-32. PubMed ID: 8626428
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells.
    Sakaue H; Hara K; Noguchi T; Matozaki T; Kotani K; Ogawa W; Yonezawa K; Waterfield MD; Kasuga M
    J Biol Chem; 1995 May; 270(19):11304-9. PubMed ID: 7744767
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Insulin-induced desensitization of extracellular signal-regulated kinase activation results from an inhibition of Raf activity independent of Ras activation and dissociation of the Grb2-SOS complex.
    Fucini RV; Okada S; Pessin JE
    J Biol Chem; 1999 Jun; 274(26):18651-8. PubMed ID: 10373477
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Insulin receptor-mediated dissociation of Grb2 from Sos involves phosphorylation of Sos by kinase(s) other than extracellular signal-regulated kinase.
    Zhao H; Okada S; Pessin JE; Koretzky GA
    J Biol Chem; 1998 May; 273(20):12061-7. PubMed ID: 9575148
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology 2 domains, in insulin-stimulated Ras activation.
    Noguchi T; Matozaki T; Horita K; Fujioka Y; Kasuga M
    Mol Cell Biol; 1994 Oct; 14(10):6674-82. PubMed ID: 7935386
    [TBL] [Abstract][Full Text] [Related]  

  • 7. MAP kinase phosphorylation of mSos1 promotes dissociation of mSos1-Shc and mSos1-EGF receptor complexes.
    Rozakis-Adcock M; van der Geer P; Mbamalu G; Pawson T
    Oncogene; 1995 Oct; 11(7):1417-26. PubMed ID: 7478566
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Interactive roles of Ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes.
    Chuang LM; Hausdorff SF; Myers MG; White MF; Birnbaum MJ; Kahn CR
    J Biol Chem; 1994 Nov; 269(44):27645-9. PubMed ID: 7961682
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Negative feedback regulation and desensitization of insulin- and epidermal growth factor-stimulated p21ras activation.
    Langlois WJ; Sasaoka T; Saltiel AR; Olefsky JM
    J Biol Chem; 1995 Oct; 270(43):25320-3. PubMed ID: 7592690
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Signal transduction pathways from insulin receptors to Ras. Analysis by mutant insulin receptors.
    Yonezawa K; Ando A; Kaburagi Y; Yamamoto-Honda R; Kitamura T; Hara K; Nakafuku M; Okabayashi Y; Kadowaki T; Kaziro Y
    J Biol Chem; 1994 Feb; 269(6):4634-40. PubMed ID: 7508445
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Association between GRB2/Sos and insulin receptor substrate 1 is not sufficient for activation of extracellular signal-regulated kinases by interleukin-4: implications for Ras activation by insulin.
    Pruett W; Yuan Y; Rose E; Batzer AG; Harada N; Skolnik EY
    Mol Cell Biol; 1995 Mar; 15(3):1778-85. PubMed ID: 7862167
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Recombinant human alpha 2-HS glycoprotein inhibits insulin-stimulated mitogenic pathway without affecting metabolic signalling in Chinese hamster ovary cells overexpressing the human insulin receptor.
    Srinivas PR; Deutsch DD; Mathews ST; Goustin AS; Leon MA; Grunberger G
    Cell Signal; 1996 Dec; 8(8):567-73. PubMed ID: 9115849
    [TBL] [Abstract][Full Text] [Related]  

  • 13. p21Ras activation by the guanine nucleotide exchange factor Sos, requires the Sos/Grb2 interaction and a second ligand-dependent signal involving the Sos N-terminus.
    Byrne JL; Paterson HF; Marshall CJ
    Oncogene; 1996 Nov; 13(10):2055-65. PubMed ID: 8950972
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases.
    Tanaka S; Hanafusa H
    J Biol Chem; 1998 Jan; 273(3):1281-4. PubMed ID: 9430657
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A mutant insulin receptor induces formation of a Shc-growth factor receptor bound protein 2 (Grb2) complex and p21ras-GTP without detectable interaction of insulin receptor substrate 1 (IRS1) with Grb2. Evidence for IRS1-independent p21ras-GTP formation.
    Ouwens DM; van der Zon GC; Pronk GJ; Bos JL; Möller W; Cheatham B; Kahn CR; Maassen JA
    J Biol Chem; 1994 Dec; 269(52):33116-22. PubMed ID: 7806540
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A Sos-derived peptidimer blocks the Ras signaling pathway by binding both Grb2 SH3 domains and displays antiproliferative activity.
    Cussac D; Vidal M; Leprince C; Liu WQ; Cornille F; Tiraboschi G; Roques BP; Garbay C
    FASEB J; 1999 Jan; 13(1):31-8. PubMed ID: 9872927
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes.
    Okada S; Matsuda M; Anafi M; Pawson T; Pessin JE
    EMBO J; 1998 May; 17(9):2554-65. PubMed ID: 9564038
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Activation of mitogen-activated protein kinase by the A(2A)-adenosine receptor via a rap1-dependent and via a p21(ras)-dependent pathway.
    Seidel MG; Klinger M; Freissmuth M; Höller C
    J Biol Chem; 1999 Sep; 274(36):25833-41. PubMed ID: 10464324
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1.
    Samuels ML; McMahon M
    Mol Cell Biol; 1994 Dec; 14(12):7855-66. PubMed ID: 7969125
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Insulin stimulation of a MEK-dependent but ERK-independent SOS protein kinase.
    Holt KH; Kasson BG; Pessin JE
    Mol Cell Biol; 1996 Feb; 16(2):577-83. PubMed ID: 8552085
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.