BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

190 related articles for article (PubMed ID: 7802703)

  • 1. Anti-neoplastic activity of sequenced administration of O6-benzylguanine, streptozotocin, and 1,3-bis(2-chloroethyl)-1-nitrosourea in vitro and in vivo.
    Marathi UK; Dolan ME; Erickson LC
    Biochem Pharmacol; 1994 Nov; 48(11):2127-34. PubMed ID: 7802703
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Extended depletion of O6-methylguanine-DNA methyltransferase activity following O6-benzyl-2'-deoxyguanosine or O6-benzylguanine combined with streptozotocin treatment enhances 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity.
    Marathi UK; Dolan ME; Erickson LC
    Cancer Res; 1994 Aug; 54(16):4371-5. PubMed ID: 8044784
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Prolonged depletion of O6-methylguanine DNA methyltransferase activity following exposure to O6-benzylguanine with or without streptozotocin enhances 1,3-bis(2-chloroethyl)-1-nitrosourea sensitivity in vitro.
    Marathi UK; Kroes RA; Dolan ME; Erickson LC
    Cancer Res; 1993 Sep; 53(18):4281-6. PubMed ID: 8364924
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Treatment of human brain tumor xenografts with O6-benzyl-2'-deoxyguanosine and BCNU.
    Schold SC; Kokkinakis DM; Rudy JL; Moschel RC; Pegg AE
    Cancer Res; 1996 May; 56(9):2076-81. PubMed ID: 8616853
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Direct reversal of DNA damage by mutant methyltransferase protein protects mice against dose-intensified chemotherapy and leads to in vivo selection of hematopoietic stem cells.
    Ragg S; Xu-Welliver M; Bailey J; D'Souza M; Cooper R; Chandra S; Seshadri R; Pegg AE; Williams DA
    Cancer Res; 2000 Sep; 60(18):5187-95. PubMed ID: 11016647
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Potentiation of BCNU antitumor efficacy by 9-substituted O6-benzylguanines. Effect of metabolism.
    Kokkinakis DM; Moschel RC; Pegg AE; Schold SC
    Cancer Chemother Pharmacol; 2000; 45(1):69-77. PubMed ID: 10647505
    [TBL] [Abstract][Full Text] [Related]  

  • 7. O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU.
    Phillips WP; Willson JK; Markowitz SD; Zborowska E; Zaidi NH; Liu L; Gordon NH; Gerson SL
    Cancer Res; 1997 Nov; 57(21):4817-23. PubMed ID: 9354444
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme.
    Friedman HS; Dolan ME; Moschel RC; Pegg AE; Felker GM; Rich J; Bigner DD; Schold SC
    J Natl Cancer Inst; 1992 Dec; 84(24):1926-31. PubMed ID: 1334154
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Sensitization of pancreatic tumor xenografts to carmustine and temozolomide by inactivation of their O6-Methylguanine-DNA methyltransferase with O6-benzylguanine or O6-benzyl-2'-deoxyguanosine.
    Kokkinakis DM; Ahmed MM; Chendil D; Moschel RC; Pegg AE
    Clin Cancer Res; 2003 Sep; 9(10 Pt 1):3801-7. PubMed ID: 14506174
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea.
    Kreklau EL; Pollok KE; Bailey BJ; Liu N; Hartwell JR; Williams DA; Erickson LC
    Mol Cancer Ther; 2003 Dec; 2(12):1321-9. PubMed ID: 14707273
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Treatment of subcutaneous and intracranial brain tumor xenografts with O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea.
    Felker GM; Friedman HS; Dolan ME; Moschel RC; Schold C
    Cancer Chemother Pharmacol; 1993; 32(6):471-6. PubMed ID: 8258196
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide.
    Kokkinakis DM; Bocangel DB; Schold SC; Moschel RC; Pegg AE
    Clin Cancer Res; 2001 Feb; 7(2):421-8. PubMed ID: 11234899
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Comparison of single- versus double-bolus treatments of O(6)-benzylguanine for depletion of O(6)-methylguanine DNA methyltransferase (MGMT) activity in vivo: development of a novel fluorometric oligonucleotide assay for measurement of MGMT activity.
    Kreklau EL; Liu N; Li Z; Cornetta K; Erickson LC
    J Pharmacol Exp Ther; 2001 May; 297(2):524-30. PubMed ID: 11303039
    [TBL] [Abstract][Full Text] [Related]  

  • 14. DeltaMGMT-transduced bone marrow infusion increases tolerance to O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea and allows intensive therapy of 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant human colon cancer xenografts.
    KoƧ ON; Reese JS; Davis BM; Liu L; Majczenko KJ; Gerson SL
    Hum Gene Ther; 1999 Apr; 10(6):1021-30. PubMed ID: 10223735
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Eradication of human medulloblastoma tumor xenografts with a combination of O6-benzyl-2'-deoxyguanosine and 1,3-bis(2-chloroethyl)1-nitrosourea.
    Kokkinakis DM; Moschel RC; Pegg AE; Schold SC
    Clin Cancer Res; 1999 Nov; 5(11):3676-81. PubMed ID: 10589786
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effect of O6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation.
    Mitchell RB; Moschel RC; Dolan ME
    Cancer Res; 1992 Mar; 52(5):1171-5. PubMed ID: 1737376
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo.
    Kreklau EL; Kurpad C; Williams DA; Erickson LC
    J Pharmacol Exp Ther; 1999 Dec; 291(3):1269-75. PubMed ID: 10565851
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synergistic efficacy of O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone.
    Gerson SL; Zborowska E; Norton K; Gordon NH; Willson JK
    Biochem Pharmacol; 1993 Jan; 45(2):483-91. PubMed ID: 8435098
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer.
    Liu L; Schwartz S; Davis BM; Gerson SL
    Cancer Res; 2002 Jun; 62(11):3070-6. PubMed ID: 12036916
    [TBL] [Abstract][Full Text] [Related]  

  • 20. O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.
    Wedge SR; Newlands ES
    Br J Cancer; 1996 May; 73(9):1049-52. PubMed ID: 8624262
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.