These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

252 related articles for article (PubMed ID: 7850779)

  • 21. Protection of CCRF-CEM human lymphoid cells from antifolates by retroviral gene transfer of variants of murine dihydrofolate reductase.
    Mareya SM; Sorrentino BP; Blakley RL
    Cancer Gene Ther; 1998; 5(4):225-35. PubMed ID: 9694074
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Variable expression of RFC1 in human leukemia cell lines resistant to antifolates.
    Kobayashi H; Takemura Y; Ohnuma T
    Cancer Lett; 1998 Feb; 124(2):135-42. PubMed ID: 9500202
    [TBL] [Abstract][Full Text] [Related]  

  • 23. A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells.
    Sharma RC; Assaraf YG; Schimke RT
    Cancer Res; 1991 Jun; 51(11):2949-59. PubMed ID: 1674447
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Determinants of trimetrexate lethality in human colon cancer cells.
    Grem JL; Voeller DM; Geoffroy F; Horak E; Johnston PG; Allegra CJ
    Br J Cancer; 1994 Dec; 70(6):1075-84. PubMed ID: 7981057
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Molecular mechanisms of resistance to antifolates, a review.
    Banerjee D; Ercikan-Abali E; Waltham M; Schnieders B; Hochhauser D; Li WW; Fan J; Gorlick R; Goker E; Bertino JR
    Acta Biochim Pol; 1995; 42(4):457-64. PubMed ID: 8852336
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Characterization of a lipophilic antifolate resistance provoked by treatment of mammalian cells with the antiparasitic agent pyrimethamine.
    Assaraf YG; Slotky JI
    J Biol Chem; 1993 Feb; 268(6):4556-66. PubMed ID: 8440739
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Modulation of dihydrofolate reductase gene expression in methotrexate-resistant human leukemia CCRF-CEM/E cells by antisense oligonucleotides.
    Morganti M; Coronnello M; Caciagli B; Biondi C; Quattrone A; Capaccioli S; Mazzei T; Mini E
    Anticancer Drugs; 2000 Apr; 11(4):285-94. PubMed ID: 10898545
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Design and rationale for novel antifolates.
    Bertino JR; Sobrero A; Mini E; Moroson BA; Cashmore A
    NCI Monogr; 1987; (5):87-91. PubMed ID: 3431593
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
    Chen G; Wright JE; Rosowsky A
    Mol Pharmacol; 1995 Oct; 48(4):758-65. PubMed ID: 7476904
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Mutations leading to antifolate resistance in Chinese hamster ovary cells after exposure to the alkylating agent ethylmethanesulfonate.
    Fanin R; Banerjee D; Volkenandt M; Waltham M; Li WW; Dicker AP; Schweitzer BI; Bertino JR
    Mol Pharmacol; 1993 Jul; 44(1):13-21. PubMed ID: 8341268
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Conformational analysis of the lipophilic antifolate trimetrexate.
    Hoffman VA; Welsh WJ
    Cancer Biochem Biophys; 1995 Jan; 14(4):281-95. PubMed ID: 7767902
    [TBL] [Abstract][Full Text] [Related]  

  • 32. The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells.
    Takemura Y; Kobayashi H; Gibson W; Kimbell R; Miyachi H; Jackman AL
    Int J Cancer; 1996 Mar; 66(1):29-36. PubMed ID: 8608962
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Characterization by flow cytometry and fluorescein-methotrexate labeling of hydrophilic and lipophilic antifolate resistance in cultured mammalian cells.
    Assaraf YG
    Anticancer Drugs; 1993 Oct; 4(5):535-44. PubMed ID: 8292810
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Amplification of a polymorphic dihydrofolate reductase gene expressing an enzyme with decreased binding to methotrexate in a human colon carcinoma cell line, HCT-8R4, resistant to this drug.
    Srimatkandada S; Schweitzer BI; Moroson BA; Dube S; Bertino JR
    J Biol Chem; 1989 Feb; 264(6):3524-8. PubMed ID: 2914962
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation.
    Dicker AP; Waltham MC; Volkenandt M; Schweitzer BI; Otter GM; Schmid FA; Sirotnak FM; Bertino JR
    Proc Natl Acad Sci U S A; 1993 Dec; 90(24):11797-801. PubMed ID: 8265628
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Large diversity in transport-mediated methotrexate resistance in human leukemia cell line CCRF-CEM established in a high concentration of leucovorin.
    Asai S; Miyachi H; Kobayashi H; Takemura Y; Ando Y
    Cancer Sci; 2003 Feb; 94(2):210-4. PubMed ID: 12708499
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
    Rhee MS; Galivan J; Wright JE; Rosowsky A
    Mol Pharmacol; 1994 Apr; 45(4):783-91. PubMed ID: 7514264
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folate repletion, confer drug resistance to CHL cells.
    Zhu WY; Bunni M; Priest DG; DiCapua JL; Dressler JM; Chen Z; Melera PW
    J Exp Ther Oncol; 2002; 2(5):264-77. PubMed ID: 12416030
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Isolation and characterization of a dihydrofolate reductase gene mutation in methotrexate-resistant Drosophila cells.
    Hao H; Tyshenko MG; Walker VK
    Gene Expr; 1996; 6(4):231-9. PubMed ID: 9196078
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Cellular and molecular mechanisms of resistance to antifolate drugs: new analogues and approaches to overcome the resistance.
    Takemura Y; Kobayashi H; Miyachi H
    Int J Hematol; 1997 Dec; 66(4):459-77. PubMed ID: 9479873
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 13.