These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

137 related articles for article (PubMed ID: 7853347)

  • 1. Mechanism-based isocoumarin inhibitors for human leukocyte elastase. Effect of the 7-amino substituent and 3-alkoxy group in 3-alkoxy-7-amino-4-chloroisocoumarins on inhibitory potency.
    Kerrigan JE; Oleksyszyn J; Kam CM; Selzler J; Powers JC
    J Med Chem; 1995 Feb; 38(3):544-52. PubMed ID: 7853347
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Effect of the 7-amino substituent on the inhibitory potency of mechanism-based isocoumarin inhibitors for porcine pancreatic and human neutrophil elastases: a 1.85-A X-ray structure of the complex between porcine pancreatic elastase and 7-[(N-tosylphenylalanyl)amino]-4-chloro-3- methoxyisocoumarin.
    Hernandez MA; Powers JC; Glinski J; Oleksyszyn J; Vijayalakshmi J; Meyer EF
    J Med Chem; 1992 Mar; 35(6):1121-9. PubMed ID: 1552505
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Reaction of porcine pancreatic elastase with 7-substituted 3-alkoxy-4-chloroisocoumarins: design of potent inhibitors using the crystal structure of the complex formed with 4-chloro-3-ethoxy-7-guanidinoisocoumarin.
    Powers JC; Oleksyszyn J; Narasimhan SL; Kam CM
    Biochemistry; 1990 Mar; 29(12):3108-18. PubMed ID: 2337582
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Reaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: new reactive mechanism-based inhibitors.
    Harper JW; Powers JC
    Biochemistry; 1985 Dec; 24(25):7200-13. PubMed ID: 3910097
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Biotinylated isocoumarins, new inhibitors and reagents for detection, localization, and isolation of serine proteases.
    Kam CM; Abuelyaman AS; Li Z; Hudig D; Powers JC
    Bioconjug Chem; 1993; 4(6):560-7. PubMed ID: 8305526
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mechanism-based isocoumarin inhibitors for blood coagulation serine proteases. Effect of the 7-substituent in 7-amino-4-chloro-3-(isothioureidoalkoxy)isocoumarins on inhibitory and anticoagulant potency.
    Kam CM; Kerrigan JE; Plaskon RR; Duffy EJ; Lollar P; Suddath FL; Powers JC
    J Med Chem; 1994 Apr; 37(9):1298-306. PubMed ID: 8176707
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanism-based isocoumarin inhibitors for trypsin and blood coagulation serine proteases: new anticoagulants.
    Kam CM; Fujikawa K; Powers JC
    Biochemistry; 1988 Apr; 27(7):2547-57. PubMed ID: 3164217
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Stereoselective synthesis of peptidyl trifluoromethyl alcohols and ketones: inhibitory potency against human leucocyte elastase, cathepsin G, porcine pancreatic elastase and HIV-1 protease.
    Amour A; Reboud-Ravaux M; de Rosny E; Abouabdellah A; Bégue JP; Bonnet-Delpon D; Le Gall M
    J Pharm Pharmacol; 1998 Jun; 50(6):593-600. PubMed ID: 9680068
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Inhibition of human leukocyte elastase (HLE) by N-substituted peptidyl trifluoromethyl ketones.
    Skiles JW; Fuchs V; Miao C; Sorcek R; Grozinger KG; Mauldin SC; Vitous J; Mui PW; Jacober S; Chow G
    J Med Chem; 1992 Feb; 35(4):641-62. PubMed ID: 1542092
    [TBL] [Abstract][Full Text] [Related]  

  • 10. 6-Acylamino-2-1[(ethylsulfonyl)oxy]-1H-isoindole-1,3-diones mechanism-based inhibitors of human leukocyte elastase and cathepsin G: effect of chirality in the 6-acylamino substituent on inhibitory potency and selectivity.
    Vagnoni LM; Gronostaj M; Kerrigan JE
    Bioorg Med Chem; 2001 Mar; 9(3):637-45. PubMed ID: 11310598
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Inhibition of human leukocyte elastase by N-substituted peptides containing alpha,alpha-difluorostatone residues at P1.
    Skiles JW; Miao C; Sorcek R; Jacober S; Mui PW; Chow G; Weldon SM; Possanza G; Skoog M; Keirns J
    J Med Chem; 1992 Dec; 35(26):4795-808. PubMed ID: 1479581
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Non-peptidic inhibitors of human leukocyte elastase. 1. The design and synthesis of pyridone-containing inhibitors.
    Warner P; Green RC; Gomes B; Strimpler AM
    J Med Chem; 1994 Sep; 37(19):3090-9. PubMed ID: 7932532
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Nonpeptidic inhibitors of human leukocyte elastase. 2. Design, synthesis, and in vitro activity of a series of 3-amino-6-arylopyridin-2-one trifluoromethyl ketones.
    Damewood JR; Edwards PD; Feeney S; Gomes BC; Steelman GB; Tuthill PA; Williams JC; Warner P; Woolson SA; Wolanin DJ
    J Med Chem; 1994 Sep; 37(20):3303-12. PubMed ID: 7932558
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Orally active beta-lactam inhibitors of human leukocyte elastase-1. Activity of 3,3-diethyl-2-azetidinones.
    Shah SK; Dorn CP; Finke PE; Hale JJ; Hagmann WK; Brause KA; Chandler GO; Kissinger AL; Ashe BM; Weston H
    J Med Chem; 1992 Oct; 35(21):3745-54. PubMed ID: 1433189
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural study of porcine pancreatic elastase complexed with 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin as a nonreactivatable doubly covalent enzyme-inhibitor complex.
    Vijayalakshmi J; Meyer EF; Kam CM; Powers JC
    Biochemistry; 1991 Feb; 30(8):2175-83. PubMed ID: 1998677
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Coumarin and isocoumarin as serine protease inhibitors.
    Pochet L; Frédérick R; Masereel B
    Curr Pharm Des; 2004; 10(30):3781-96. PubMed ID: 15579071
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones.
    Bernstein PR; Andisik D; Bradley PK; Bryant CB; Ceccarelli C; Damewood JR; Earley R; Edwards PD; Feeney S; Gomes BC
    J Med Chem; 1994 Sep; 37(20):3313-26. PubMed ID: 7932559
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mechanism-based inhibition of human leukocyte elastase and cathepsin G by substituted dihydrouracils.
    Groutas WC; Huang H; Epp JB; Venkataraman R; McClenahan JJ; Tagusagawa F
    Biochim Biophys Acta; 1994 Nov; 1227(3):130-6. PubMed ID: 7986820
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins.
    Shah SK; Brause KA; Chandler GO; Finke PE; Ashe BM; Weston H; Knight WB; Maycock AL; Doherty JB
    J Med Chem; 1990 Sep; 33(9):2529-35. PubMed ID: 2391693
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-activity studies of fluoroketone inhibitors of alpha-lytic protease and human leukocyte elastase.
    Govardhan CP; Abeles RH
    Arch Biochem Biophys; 1990 Jul; 280(1):137-46. PubMed ID: 2353815
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.