187 related articles for article (PubMed ID: 7860738)
1. Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells.
Cui L; Yoon S; Schinazi RF; Sommadossi JP
J Clin Invest; 1995 Feb; 95(2):555-63. PubMed ID: 7860738
[TBL] [Abstract][Full Text] [Related]
2. Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts.
Lewis W; Levine ES; Griniuviene B; Tankersley KO; Colacino JM; Sommadossi JP; Watanabe KA; Perrino FW
Proc Natl Acad Sci U S A; 1996 Apr; 93(8):3592-7. PubMed ID: 8622980
[TBL] [Abstract][Full Text] [Related]
3. Toxicity, metabolism, DNA incorporation with lack of repair, and lactate production for 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)-5-iodouracil in U-937 and MOLT-4 cells.
Klecker RW; Katki AG; Collins JM
Mol Pharmacol; 1994 Dec; 46(6):1204-9. PubMed ID: 7808443
[TBL] [Abstract][Full Text] [Related]
4. Depletion of mitochondrial DNA, destruction of mitochondria, and accumulation of lipid droplets result from fialuridine treatment in woodchucks (Marmota monax).
Lewis W; Griniuviene B; Tankersley KO; Levine ES; Montione R; Engelman L; de Courten-Myers G; Ascenzi MA; Hornbuckle WE; Gerin JL; Tennant BC
Lab Invest; 1997 Jan; 76(1):77-87. PubMed ID: 9010451
[TBL] [Abstract][Full Text] [Related]
5. Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications for cytotoxicity.
Wang J; Eriksson S
Antimicrob Agents Chemother; 1996 Jun; 40(6):1555-7. PubMed ID: 8726039
[TBL] [Abstract][Full Text] [Related]
6. Effect of fialuridine on replication of mitochondrial DNA in CEM cells and in human hepatoblastoma cells in culture.
Colacino JM; Malcolm SK; Jaskunas SR
Antimicrob Agents Chemother; 1994 Sep; 38(9):1997-2002. PubMed ID: 7811009
[TBL] [Abstract][Full Text] [Related]
7. Effect of beta-enantiomeric and racemic nucleoside analogues on mitochondrial functions in HepG2 cells. Implications for predicting drug hepatotoxicity.
Cui L; Schinazi RF; Gosselin G; Imbach JL; Chu CK; Rando RF; Revankar GR; Sommadossi JP
Biochem Pharmacol; 1996 Nov; 52(10):1577-84. PubMed ID: 8937473
[TBL] [Abstract][Full Text] [Related]
8. Inhibition of hepatitis B virus by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyl uracil.
Balakrishna Pai S; Liu SH; Zhu YL; Chu CK; Cheng YC
Antimicrob Agents Chemother; 1996 Feb; 40(2):380-6. PubMed ID: 8834884
[TBL] [Abstract][Full Text] [Related]
9. Effect of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-ethyluracil on mitochondrial functions in HepG2 cells.
Cui L; Faraj A; Sommadossi JP
Antiviral Res; 1999 Oct; 43(3):201-7. PubMed ID: 10551377
[TBL] [Abstract][Full Text] [Related]
10. Fialuridine is phosphorylated and inhibits DNA synthesis in isolated rat hepatic mitochondria.
Horn DM; Neeb LA; Colacino JM; Richardson FC
Antiviral Res; 1997 Mar; 34(1):71-4. PubMed ID: 9107387
[TBL] [Abstract][Full Text] [Related]
11. Synthesis of 2'-deoxy-2'-[18F]fluoro-beta-D-arabinofuranosyl nucleosides, [18F]FAU, [18F]FMAU, [18F]FBAU and [18F]FIAU, as potential PET agents for imaging cellular proliferation. Synthesis of [18F]labelled FAU, FMAU, FBAU, FIAU.
Mangner TJ; Klecker RW; Anderson L; Shields AF
Nucl Med Biol; 2003 Apr; 30(3):215-24. PubMed ID: 12745012
[TBL] [Abstract][Full Text] [Related]
12. The in vitro anti-hepatitis B virus activity of FIAU [1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl-5-iodo)uracil] is selective, reversible, and determined, at least in part, by the host cell.
Staschke KA; Colacino JM; Mabry TE; Jones CD
Antiviral Res; 1994 Jan; 23(1):45-61. PubMed ID: 8141592
[TBL] [Abstract][Full Text] [Related]
13. Mitochondrial and cellular toxicity induced by fialuridine in human muscle in vitro.
Semino-Mora C; Leon-Monzon M; Dalakas MC
Lab Invest; 1997 Apr; 76(4):487-95. PubMed ID: 9111511
[TBL] [Abstract][Full Text] [Related]
14. Mitochondrial expression of the human equilibrative nucleoside transporter 1 (hENT1) results in enhanced mitochondrial toxicity of antiviral drugs.
Lai Y; Tse CM; Unadkat JD
J Biol Chem; 2004 Feb; 279(6):4490-7. PubMed ID: 14607828
[TBL] [Abstract][Full Text] [Related]
15. Nucleosides. 150. Synthesis and some biological properties of 5-monofluoromethyl, 5-difluoromethyl, and 5-trifluoromethyl derivatives of 2'-deoxyuridine and 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyluracil.
Matulic-Adamic J; Takahashi K; Chou TC; Gadler H; Price RW; Reddy AR; Kalman TI; Watanabe KA
J Med Chem; 1988 Aug; 31(8):1642-7. PubMed ID: 2840503
[TBL] [Abstract][Full Text] [Related]
16. Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing.
Xu D; Nishimura T; Nishimura S; Zhang H; Zheng M; Guo YY; Masek M; Michie SA; Glenn J; Peltz G
PLoS Med; 2014 Apr; 11(4):e1001628. PubMed ID: 24736310
[TBL] [Abstract][Full Text] [Related]
17. Activity of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodouracil against simian varicella virus infections in African green monkeys.
Soike KF; Cantrell C; Gerone PJ
Antimicrob Agents Chemother; 1986 Jan; 29(1):20-5. PubMed ID: 3729332
[TBL] [Abstract][Full Text] [Related]
18. Comparison of the DNA incorporation in human MOLT-4 cells of two 2'-beta-fluoronucleosides, 2'-beta-fluoro-2',3'-dideoxyadenosine and fialuridine.
Ahluwalia GS; Driscoll JS; Ford H; Johns DG
J Pharm Sci; 1996 Apr; 85(4):454-5. PubMed ID: 8901088
[TBL] [Abstract][Full Text] [Related]
19. Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate.
Lewis W; Meyer RR; Simpson JF; Colacino JM; Perrino FW
Biochemistry; 1994 Dec; 33(48):14620-4. PubMed ID: 7981224
[TBL] [Abstract][Full Text] [Related]
20. Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.
McKenzie R; Fried MW; Sallie R; Conjeevaram H; Di Bisceglie AM; Park Y; Savarese B; Kleiner D; Tsokos M; Luciano C
N Engl J Med; 1995 Oct; 333(17):1099-105. PubMed ID: 7565947
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
