BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

96 related articles for article (PubMed ID: 7884657)

  • 1. Whole-body autoradiographic disposition and plasma pharmacokinetics of 5,10-dideazatetrahydrofolic acid in mice fed folic acid-deficient or regular diets.
    Pohland RC; Alati T; Lantz RJ; Grindey GB
    J Pharm Sci; 1994 Oct; 83(10):1396-9. PubMed ID: 7884657
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Whole-body disposition and polyglutamate distribution of the GAR formyltransferase inhibitors LY309887 and lometrexol in mice: effect of low-folate diet.
    Habeck LL; Chay SH; Pohland RC; Worzalla JF; Shih C; Mendelsohn LG
    Cancer Chemother Pharmacol; 1998; 41(3):201-9. PubMed ID: 9443636
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Impact of dietary folic acid on reduced folates in mouse plasma and tissues. Relationship to dideazatetrahydrofolate sensitivity.
    Schmitz JC; Grindey GB; Schultz RM; Priest DG
    Biochem Pharmacol; 1994 Jul; 48(2):319-25. PubMed ID: 8053927
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid.
    Erba E; Sen S; Sessa C; Vikhanskaya FL; D'Incalci M
    Br J Cancer; 1994 Feb; 69(2):205-11. PubMed ID: 8297715
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Role of membrane folate-binding protein in the cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cell lines in vitro.
    Sen S; Erba E; D'Incalci M; Bottero F; Canevari S; Tomassetti A
    Br J Cancer; 1996 Feb; 73(4):525-30. PubMed ID: 8595169
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Growth-inhibitory effects of 5,10-dideazatetrahydrofolic acid on variant murine L1210 and human CCRF-CEM leukemia cells with different membrane-transport characteristics for (anti)folate compounds.
    Jansen G; Westerhof GR; Kathmann I; Rijksen G; Schornagel JH
    Cancer Chemother Pharmacol; 1991; 28(2):115-7. PubMed ID: 2060081
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Role of membrane-associated folate binding protein in the cytotoxicity of antifolates in KB, IGROV1, and L1210A cells.
    Schultz RM; Andis SL; Shackelford KA; Gates SB; Ratnam M; Mendelsohn LG; Shih C; Grindey GB
    Oncol Res; 1995; 7(2):97-102. PubMed ID: 7579732
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier.
    Zhao R; Gao F; Babani S; Goldman ID
    Clin Cancer Res; 2000 Aug; 6(8):3304-11. PubMed ID: 10955817
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Investigation of the effects of folate deficiency on embryonic development through the establishment of a folate deficient mouse model.
    Burgoon JM; Selhub J; Nadeau M; Sadler TW
    Teratology; 2002 May; 65(5):219-27. PubMed ID: 11967921
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Tissue levels of S-adenosylmethionine and S-adenosylhomocysteine in rats fed methyl-deficient, amino acid-defined diets for one to five weeks.
    Shivapurkar N; Poirier LA
    Carcinogenesis; 1983 Aug; 4(8):1051-7. PubMed ID: 6872150
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Enhancement of antineoplastic activity of 5-fluorouracil in mice bearing colon 38 tumor by (6R)5,10-dideazatetrahydrofolic acid.
    Pizzorno G; Davis SJ; Hartigan DJ; Russello O
    Biochem Pharmacol; 1994 Jun; 47(11):1981-8. PubMed ID: 7516657
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Pharmacokinetics, antifolate activity and tissue distribution of PT523 in SCC VII tumor-bearing mice.
    Wright JE; Pardo M; Tretyakov A; Alperin WL; Trites D; Rosowsky A
    Cancer Chemother Pharmacol; 1998; 42(4):300-6. PubMed ID: 9744775
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Induction of HL-60 leukemia cell differentiation by the novel antifolate 5,10-dideazatetrahydrofolic acid.
    Sokoloski JA; Beardsley GP; Sartorelli AC
    Cancer Res; 1989 Sep; 49(17):4824-8. PubMed ID: 2758415
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase.
    Chong LK; Tattersall MH
    Biochem Pharmacol; 1995 Mar; 49(6):819-27. PubMed ID: 7702640
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport.
    Matherly LH; Angeles SM; McGuire JJ
    Biochem Pharmacol; 1993 Dec; 46(12):2185-95. PubMed ID: 7506026
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid.
    Laohavinij S; Wedge SR; Lind MJ; Bailey N; Humphreys A; Proctor M; Chapman F; Simmons D; Oakley A; Robson L; Gumbrell L; Taylor GA; Thomas HD; Boddy AV; Newell DR; Calvert AH
    Invest New Drugs; 1996; 14(3):325-35. PubMed ID: 8958188
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cellular but not plasma pharmacokinetics of lometrexol correlate with the occurrence of cumulative hematological toxicity.
    Synold TW; Newman EM; Carroll M; Muggia FM; Groshen S; Johnson K; Doroshow JH
    Clin Cancer Res; 1998 Oct; 4(10):2349-55. PubMed ID: 9796964
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Effects of ethanol on tissue folate incorporation and recovery from folate deficiency in rats.
    Collins TD; Eisenga BH; Bhandari SD; McMartin KE
    Alcohol Clin Exp Res; 1992 Aug; 16(4):757-63. PubMed ID: 1530139
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evidence for a relationship between intracellular GTP levels and the induction of HL-60 leukemia cell differentiation by 5,10-dideazatetrahydrofolic acid (DDATHF).
    Sokoloski JA; Pizzorno G; Beardsley GP; Sartorelli AC
    Oncol Res; 1993; 5(8):293-9. PubMed ID: 8012061
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF).
    Pavlovic M; Leffert JJ; Russello O; Bunni MA; Beardsley GP; Priest DG; Pizzorno G
    Adv Exp Med Biol; 1993; 338():775-8. PubMed ID: 8304227
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 5.