These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

87 related articles for article (PubMed ID: 7922702)

  • 1. Ab initio studies of 2,4-diamino triazine and its complexes with ligands: a model for inhibitor-active site interactions of dihydrofolate reductase.
    Sapse AM; Waltham MC; Bertino JR
    Cancer Invest; 1994; 12(5):469-76. PubMed ID: 7922702
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase.
    Cummins PL; Gready JE
    J Am Chem Soc; 2001 Apr; 123(15):3418-28. PubMed ID: 11472112
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ab initio studies of aromatic-aromatic and aromatic-polar interactions in the binding of substrate and inhibitor to dihydrofolate reductase.
    Sapse AM; Schweitzer BS; Dicker AP; Bertino JR; Frecer V
    Int J Pept Protein Res; 1992 Jan; 39(1):18-23. PubMed ID: 1299221
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Ligand binding studies, preliminary structure-activity relationship and detailed mechanistic characterization of 1-phenyl-6,6-dimethyl-1,3,5-triazine-2,4-diamine derivatives as inhibitors of Escherichia coli dihydrofolate reductase.
    Srinivasan B; Tonddast-Navaei S; Skolnick J
    Eur J Med Chem; 2015 Oct; 103():600-14. PubMed ID: 26414808
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Conformational analysis of lipophilic antifolates: crystal and molecular structures of three s-triazine dihydrofolate reductase inhibitors.
    Cody V; Sutton PA
    Anticancer Drug Des; 1987 Dec; 2(3):253-62. PubMed ID: 3449089
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Effects of variable selection on CoMFA coefficient contour maps in a set of triazines inhibiting DHFR.
    Greco G; Novellino E; Pellecchia M; Silipo C; Vittoria A
    J Comput Aided Mol Des; 1994 Apr; 8(2):97-112. PubMed ID: 8064336
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Consideration of the pH-dependent inhibition of dihydrofolate reductase by methotrexate.
    Cannon WR; Garrison BJ; Benkovic SJ
    J Mol Biol; 1997 Aug; 271(4):656-68. PubMed ID: 9281432
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The pH-dependence of the binding of dihydrofolate and substrate analogues to dihydrofolate reductase from Escherichia coli.
    Stone SR; Morrison JF
    Biochim Biophys Acta; 1983 Jun; 745(3):247-58. PubMed ID: 6344924
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Triazine-benzimidazole hybrids: anticancer activity, DNA interaction and dihydrofolate reductase inhibitors.
    Singla P; Luxami V; Paul K
    Bioorg Med Chem; 2015 Apr; 23(8):1691-700. PubMed ID: 25792141
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum.
    Vilaivan T; Saesaengseerung N; Jarprung D; Kamchonwongpaisan S; Sirawaraporn W; Yuthavong Y
    Bioorg Med Chem; 2003 Jan; 11(2):217-24. PubMed ID: 12470716
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Voronoi modeling: the binding of triazines and pyrimidines to L. casei dihydrofolate reductase.
    Bradley MP; Crippen GM
    J Med Chem; 1993 Oct; 36(21):3171-7. PubMed ID: 8230104
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase.
    Huang Z; Wagner CR; Benkovic SJ
    Biochemistry; 1994 Sep; 33(38):11576-85. PubMed ID: 7918371
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Crystal structures of recombinant human dihydrofolate reductase complexed with folate and 5-deazafolate.
    Davies JF; Delcamp TJ; Prendergast NJ; Ashford VA; Freisheim JH; Kraut J
    Biochemistry; 1990 Oct; 29(40):9467-79. PubMed ID: 2248959
    [TBL] [Abstract][Full Text] [Related]  

  • 14. 13C and 15N nuclear magnetic resonance evidence that the active site carboxyl group of dihydrofolate reductase is not involved in the relay of a proton to substrate.
    Blakley RL; Appleman JR; Freisheim JH; Jablonsky MJ
    Arch Biochem Biophys; 1993 Nov; 306(2):501-9. PubMed ID: 8105754
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Kinetics of the inhibition of bovine liver dihydrofolate reductase by tea catechins: origin of slow-binding inhibition and pH studies.
    Navarro-Perán E; Cabezas-Herrera J; Hiner AN; Sadunishvili T; García-Cánovas F; Rodríguez-López JN
    Biochemistry; 2005 May; 44(20):7512-25. PubMed ID: 15895994
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The crystal structure of dihydrofolate reductase from Thermotoga maritima: molecular features of thermostability.
    Dams T; Auerbach G; Bader G; Jacob U; Ploom T; Huber R; Jaenicke R
    J Mol Biol; 2000 Mar; 297(3):659-72. PubMed ID: 10731419
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo.
    Mui EJ; Jacobus D; Milhous WK; Schiehser G; Hsu H; Roberts CW; Kirisits MJ; McLeod R
    Antimicrob Agents Chemother; 2005 Aug; 49(8):3463-7. PubMed ID: 16048961
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Comparison of linear-scaling semiempirical methods and combined quantum mechanical/molecular mechanical methods for enzymic reactions. II. An energy decomposition analysis.
    Titmuss SJ; Cummins PL; Rendell AP; Bliznyuk AA; Gready JE
    J Comput Chem; 2002 Nov; 23(14):1314-22. PubMed ID: 12214314
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Irreversible enzyme inhibitors. CXII. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-phenyl-s-triazine substituted with a terminal sulfonyl fluoride. II.
    Baker BR; Lourens GJ
    J Med Chem; 1968 Jan; 11(1):38-41. PubMed ID: 5237173
    [No Abstract]   [Full Text] [Related]  

  • 20. Human dihydrofolate reductase: reduction of alternative substrates, pH effects, and inhibition by deazafolates.
    Williams EA; Morrison JF
    Biochemistry; 1992 Jul; 31(29):6801-11. PubMed ID: 1637816
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.