These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

117 related articles for article (PubMed ID: 7966150)

  • 1. Design and synthesis of potent and highly selective thrombin inhibitors.
    Hilpert K; Ackermann J; Banner DW; Gast A; Gubernator K; Hadváry P; Labler L; Müller K; Schmid G; Tschopp TB
    J Med Chem; 1994 Nov; 37(23):3889-901. PubMed ID: 7966150
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Synthesis and characterisation of novel thrombin inhibitors based on 4-amidinophenylalanine.
    Reers M; Koschinsky R; Dickneite G; Hoffmann D; Czech J; Stüber W
    J Enzyme Inhib; 1995; 9(1):61-72. PubMed ID: 8568567
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Molecular recognition at the thrombin active site: structure-based design and synthesis of potent and selective thrombin inhibitors and the X-ray crystal structures of two thrombin-inhibitor complexes.
    Obst U; Banner DW; Weber L; Diederich F
    Chem Biol; 1997 Apr; 4(4):287-95. PubMed ID: 9195869
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design, synthesis and testing of amino-bicycloaryl based orally bioavailable thrombin inhibitors.
    Rewinkel JB; Lucas H; Smit MJ; Noach AB; van Dinther TG; Rood AM; Jenneboer AJ; van Boeckel CA
    Bioorg Med Chem Lett; 1999 Oct; 9(19):2837-42. PubMed ID: 10522702
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Protease inhibitors. Part 2. Weakly basic thrombin inhibitors incorporating sulfonyl-aminoguanidine moieties as S1 anchoring groups: synthesis and structure-activity correlations.
    Clare BW; Scozzafava A; Briganti F; Iorga B; Supuran CT
    J Enzyme Inhib; 2000; 15(3):235-64. PubMed ID: 10811030
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design and synthesis of thrombin inhibitors: analogues of MD-805 with reduced stereogenicity and improved potency.
    Brundish D; Bull A; Donovan V; Fullerton JD; Garman SM; Hayler JF; Janus D; Kane PD; McDonnell M; Smith GP; Wakeford R; Walker CV; Howarth G; Hoyle W; Allen MC; Ambler J; Butler K; Talbot MD
    J Med Chem; 1999 Nov; 42(22):4584-603. PubMed ID: 10579821
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Design and synthesis of potent and selective 5,6-fused heterocyclic thrombin inhibitors.
    Dominguez C; Duffy DE; Han Q; Alexander RS; Galemmo RA; Park JM; Wong PC; Amparo EC; Knabb RM; Luettgen J; Wexler RR
    Bioorg Med Chem Lett; 1999 Apr; 9(7):925-30. PubMed ID: 10230612
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis and molecular modelling of 1-amidinopiperidine thrombin inhibitors.
    Smolnikar I; Perdih A; Stegnar M; Prezelj A; Solmajer T; Urleb U; Obreza A
    Pharmazie; 2007 Apr; 62(4):243-54. PubMed ID: 17484277
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis and structure-activity relationships of potent thrombin inhibitors: piperazides of 3-amidinophenylalanine.
    Stürzebecher J; Prasa D; Hauptmann J; Vieweg H; Wikström P
    J Med Chem; 1997 Sep; 40(19):3091-9. PubMed ID: 9301673
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design and synthesis of potent and selective macrocyclic thrombin inhibitors.
    Nantermet PG; Barrow JC; Newton CL; Pellicore JM; Young M; Lewis SD; Lucas BJ; Krueger JA; McMasters DR; Yan Y; Kuo LC; Vacca JP; Selnick HG
    Bioorg Med Chem Lett; 2003 Aug; 13(16):2781-4. PubMed ID: 12873514
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis and biological activity of novel rigid amidino-phenylalanine derivatives as inhibitors of thrombin.
    Mack H; Pfeiffer T; Hornberger W; Böhm HJ; Höffken HW
    J Enzyme Inhib; 1995; 9(1):73-86. PubMed ID: 8568568
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-activity relationships of inhibitors derived from 3-amidinophenylalanine.
    Stürzebecher J; Prasa D; Wikström P; Vieweg H
    J Enzyme Inhib; 1995; 9(1):87-99. PubMed ID: 8568569
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Thrombin inhibitors identified by computer-assisted multiparameter design.
    Riester D; Wirsching F; Salinas G; Keller M; Gebinoga M; Kamphausen S; Merkwirth C; Goetz R; Wiesenfeldt M; Stürzebecher J; Bode W; Friedrich R; Thürk M; Schwienhorst A
    Proc Natl Acad Sci U S A; 2005 Jun; 102(24):8597-602. PubMed ID: 15937115
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Amide and alpha-keto carbonyl inhibitors of thrombin based on arginine and lysine: synthesis, stability and biological characterization.
    Brady SF; Sisko JT; Stauffer KJ; Colton CD; Qiu H; Lewis SD; Ng AS; Shafer JA; Bogusky MJ; Veber DF
    Bioorg Med Chem; 1995 Aug; 3(8):1063-78. PubMed ID: 7582980
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Protease inhibitors: synthesis and QSAR study of novel classes of nonbasic thrombin inhibitors incorporating sulfonylguanidine and O-methylsulfonylisourea moieties at P1.
    Supuran CT; Scozzafava A; Briganti F; Clare BW
    J Med Chem; 2000 May; 43(9):1793-806. PubMed ID: 10794696
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Azetidin-2-one derivatives as inhibitors of thrombin.
    Han WT; Trehan AK; Wright JJ; Federici ME; Seiler SM; Meanwell NA
    Bioorg Med Chem; 1995 Aug; 3(8):1123-43. PubMed ID: 7582985
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Protease inhibitors: Part 4. Synthesis of weakly basic thrombin inhibitors incorporating pyridinium-sulfanilylaminoguanidine moieties.
    Supuran CT; Briganti F; Scozzafava A; Ilies MA
    J Enzyme Inhib; 2000; 15(4):335-56. PubMed ID: 10995066
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The design of potent and selective inhibitors of thrombin utilizing a piperazinedione template: part 2.
    Cody WL; Augelli-Szafran CE; Berryman KA; Cai C; Doherty AM; Edmunds JJ; He JX; Narasimhan LS; Penvose-Yi J; Plummer JS; Rapundalo ST; Rubin JR; Van Huis CA; Leblond L; Winocour PD; Siddiqui MA
    Bioorg Med Chem Lett; 1999 Sep; 9(17):2503-8. PubMed ID: 10498197
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-activity relationships of new NAPAP-analogs.
    Steinmetzer T; Schweinitz A; Künzel S; Wikström P; Hauptmann J; Stürzebecher J
    J Enzyme Inhib Med Chem; 2002 Apr; 17(2):241-9. PubMed ID: 12420761
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Synthesis and Biological Evaluation of Some New 2,5-Substituted 1-Ethyl-1H-benzoimidazole Fluorinated Derivatives as Direct Thrombin Inhibitors.
    Li M; Ren Y
    Arch Pharm (Weinheim); 2015 May; 348(5):353-65. PubMed ID: 25824648
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.