BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 7966151)

  • 1. Synthesis and antitumor evaluation of bis[(pivaloyloxy)methyl] 2'-deoxy-5-fluorouridine 5'-monophosphate (FdUMP): a strategy to introduce nucleotides into cells.
    Farquhar D; Khan S; Srivastva DN; Saunders PP
    J Med Chem; 1994 Nov; 37(23):3902-9. PubMed ID: 7966151
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 5'-[4-(Pivaloyloxy)-1,3,2-dioxaphosphorinan-2-yl]-2'-deoxy-5-fluorouridine: a membrane-permeating prodrug of 5-fluoro-2'-deoxyuridylic acid (FdUMP).
    Farquhar D; Chen R; Khan S
    J Med Chem; 1995 Feb; 38(3):488-95. PubMed ID: 7853342
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs.
    Tobias SC; Borch RF
    J Med Chem; 2001 Dec; 44(25):4475-80. PubMed ID: 11728193
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Sulfonyl-containing nucleoside phosphotriesters and phosphoramidates as novel anticancer prodrugs of 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP).
    Sun YW; Chen KM; Kwon CH
    Mol Pharm; 2006; 3(2):161-73. PubMed ID: 16579645
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Evidence for acyloxymethyl esters of pyrimidine 5'-deoxyribonucleotides as extracellular sources of active 5'-deoxyribonucleotides in cultured cells.
    Freed JJ; Farquhar D; Hampton A
    Biochem Pharmacol; 1989 Oct; 38(19):3193-8. PubMed ID: 2818620
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
    Liao ZY; Sordet O; Zhang HL; Kohlhagen G; Antony S; Gmeiner WH; Pommier Y
    Cancer Res; 2005 Jun; 65(11):4844-51. PubMed ID: 15930305
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis and biological evaluation of neutral derivatives of 5-fluoro-2'-deoxyuridine 5'-phosphate.
    Farquhar D; Kuttesch NJ; Wilkerson MG; Winkler T
    J Med Chem; 1983 Aug; 26(8):1153-8. PubMed ID: 6308257
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cytotoxicity and in-vivo tolerance of FdUMP[10]: a novel pro-drug of the TS inhibitory nucleotide FdUMP.
    Gmeiner WH; Skradis A; Pon RT; Liu J
    Nucleosides Nucleotides; 1999; 18(6-7):1729-30. PubMed ID: 10474257
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Antitumor effect and tumor level of 5-fluoro-2'-deoxyuridylate following oral administration of tetradecyl 2'-deoxy-5-fluoro-5'-uridylate.
    Nakajima Y; Iigo M; Hoshi A
    Anticancer Drugs; 1992 Jun; 3(3):289-92. PubMed ID: 1525410
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Antitumor activity of alkylesters of 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP) against murine lymphoma L5178Y resistant to 5-fluoro-2'-deoxyuridine.
    Kanzawa F; Matsushima Y; Ishihara J; Hoshi A; Ohba T; Watanabe K
    J Pharmacobiodyn; 1986 Aug; 9(8):688-93. PubMed ID: 2946859
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU.
    Liu J; Skradis A; Kolar C; Kolath J; Anderson J; Lawson T; Talmadge J; Gmeiner WH
    Nucleosides Nucleotides; 1999 Aug; 18(8):1789-802. PubMed ID: 10478484
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Bis(carbamoyloxymethyl) esters of 2',3'-dideoxyuridine 5'-monophosphate (ddUMP) as potential ddUMP prodrugs.
    Khan SR; Kumar SK; Farquhar D
    Pharm Res; 2005 Mar; 22(3):390-6. PubMed ID: 15835744
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Efficacy and safety of FdUMP[10] in treatment of HT-29 human colon cancer xenografts.
    Liu C; Willingham M; Liu J; Gmeiner WH
    Int J Oncol; 2002 Aug; 21(2):303-8. PubMed ID: 12118325
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Positive interaction between 5-FU and FdUMP[10] in the inhibition of human colorectal tumor cell proliferation.
    Liu J; Kolath J; Anderson J; Kolar C; Lawson TA; Talmadge J; Gmeiner WH
    Antisense Nucleic Acid Drug Dev; 1999 Oct; 9(5):481-6. PubMed ID: 10555156
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
    Bijnsdorp IV; Comijn EM; Padron JM; Gmeiner WH; Peters GJ
    Oncol Rep; 2007 Jul; 18(1):287-91. PubMed ID: 17549381
    [TBL] [Abstract][Full Text] [Related]  

  • 16. N-(5,5-diacetoxypent-1-yl)doxorubicin: a new intensely potent doxorubicin analogue.
    Cherif A; Farquhar D
    J Med Chem; 1992 Aug; 35(17):3208-14. PubMed ID: 1354750
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Synthesis and anticancer activities of amphiphilic 5-fluoro-2'-deoxyuridylic acid prodrugs.
    Ludwig PS; Schwendener RA; Schott H
    Eur J Med Chem; 2005 May; 40(5):494-504. PubMed ID: 15893023
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Intensely potent doxorubicin analogues: structure-activity relationship.
    Farquhar D; Cherif A; Bakina E; Nelson JA
    J Med Chem; 1998 Mar; 41(6):965-72. PubMed ID: 9526570
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Targeted drug delivery to chemoresistant cells: folic acid derivatization of FdUMP[10] enhances cytotoxicity toward 5-FU-resistant human colorectal tumor cells.
    Liu J; Kolar C; Lawson TA; Gmeiner WH
    J Org Chem; 2001 Aug; 66(17):5655-63. PubMed ID: 11511236
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Combined modulation by leucovorin and alpha-2a interferon of fluoropyrimidine mediated growth inhibition.
    Sinnige HA; Timmer-Bosscha H; Peters GF; De Vries EG; Mulder NH
    Anticancer Res; 1993; 13(5A):1335-40. PubMed ID: 8239504
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.