BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

371 related articles for article (PubMed ID: 7973658)

  • 1. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID.
    Russell SM; Johnston JA; Noguchi M; Kawamura M; Bacon CM; Friedmann M; Berg M; McVicar DW; Witthuhn BA; Silvennoinen O
    Science; 1994 Nov; 266(5187):1042-5. PubMed ID: 7973658
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits.
    Miyazaki T; Kawahara A; Fujii H; Nakagawa Y; Minami Y; Liu ZJ; Oishi I; Silvennoinen O; Witthuhn BA; Ihle JN
    Science; 1994 Nov; 266(5187):1045-7. PubMed ID: 7973659
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.
    Kirken RA; Rui H; Malabarba MG; Howard OM; Kawamura M; O'Shea JJ; Farrar WL
    Cytokine; 1995 Oct; 7(7):689-700. PubMed ID: 8580378
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.
    Kawahara A; Minami Y; Miyazaki T; Ihle JN; Taniguchi T
    Proc Natl Acad Sci U S A; 1995 Sep; 92(19):8724-8. PubMed ID: 7568005
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Autosomal SCID caused by a point mutation in the N-terminus of Jak3: mapping of the Jak3-receptor interaction domain.
    Cacalano NA; Migone TS; Bazan F; Hanson EP; Chen M; Candotti F; O'Shea JJ; Johnston JA
    EMBO J; 1999 Mar; 18(6):1549-58. PubMed ID: 10075926
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Requirement for an initial signal from the membrane-proximal region of the interleukin 2 receptor gamma(c) chain for Janus kinase activation leading to T cell proliferation.
    Nelson BH; McIntosh BC; Rosencrans LL; Greenberg PD
    Proc Natl Acad Sci U S A; 1997 Mar; 94(5):1878-83. PubMed ID: 9050873
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Correction of interleukin-2 receptor function in X-SCID lymphoblastoid cells by retrovirally mediated transfer of the gamma-c gene.
    Taylor N; Uribe L; Smith S; Jahn T; Kohn DB; Weinberg K
    Blood; 1996 Apr; 87(8):3103-7. PubMed ID: 8605323
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Janus kinases in interleukin-2-mediated signaling: JAK1 and JAK3 are differentially regulated by tyrosine phosphorylation.
    Liu KD; Gaffen SL; Goldsmith MA; Greene WC
    Curr Biol; 1997 Nov; 7(11):817-26. PubMed ID: 9382798
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Retroviral-mediated gene correction for X-linked severe combined immunodeficiency.
    Candotti F; Johnston JA; Puck JM; Sugamura K; O'Shea JJ; Blaese RM
    Blood; 1996 Apr; 87(8):3097-102. PubMed ID: 8605322
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.
    Oakes SA; Candotti F; Johnston JA; Chen YQ; Ryan JJ; Taylor N; Liu X; Hennighausen L; Notarangelo LD; Paul WE; Blaese RM; O'Shea JJ
    Immunity; 1996 Dec; 5(6):605-15. PubMed ID: 8986719
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.
    Russell SM; Tayebi N; Nakajima H; Riedy MC; Roberts JL; Aman MJ; Migone TS; Noguchi M; Markert ML; Buckley RH; O'Shea JJ; Leonard WJ
    Science; 1995 Nov; 270(5237):797-800. PubMed ID: 7481768
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.
    Zhu MH; Berry JA; Russell SM; Leonard WJ
    J Biol Chem; 1998 Apr; 273(17):10719-25. PubMed ID: 9553136
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Dispensability of Jak1 tyrosine kinase for interleukin-2-induced cell growth signaling in a human T cell line.
    Higuchi M; Asao H; Tanaka N; Oda K; Takeshita T; Nakamura M; Van Snick J; Sugamura K
    Eur J Immunol; 1996 Jun; 26(6):1322-7. PubMed ID: 8647212
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Regulation of IL-2 signaling.
    Higuchi M; Asao H; Tanaka N; Oda K; Takeshita T; Sugamura K
    Leukemia; 1997 Apr; 11 Suppl 3():416-7. PubMed ID: 9209410
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3.
    Habib T; Senadheera S; Weinberg K; Kaushansky K
    Biochemistry; 2002 Jul; 41(27):8725-31. PubMed ID: 12093291
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.
    Tanaka N; Asao H; Ohbo K; Ishii N; Takeshita T; Nakamura M; Sasaki H; Sugamura K
    Proc Natl Acad Sci U S A; 1994 Jul; 91(15):7271-5. PubMed ID: 8041779
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Staphylococcal enterotoxins modulate interleukin 2 receptor expression and ligand-induced tyrosine phosphorylation of the Janus protein-tyrosine kinase 3 (Jak3) and signal transducers and activators of transcription (Stat proteins).
    Nielsen M; Svejgaard A; Röpke C; Nordahl M; Odum N
    Proc Natl Acad Sci U S A; 1995 Nov; 92(24):10995-9. PubMed ID: 7479924
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A membrane-proximal region of the interleukin-2 receptor gamma c chain sufficient for Jak kinase activation and induction of proliferation in T cells.
    Nelson BH; Lord JD; Greenberg PD
    Mol Cell Biol; 1996 Jan; 16(1):309-17. PubMed ID: 8524310
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Differential substrate recognition capabilities of Janus family protein tyrosine kinases within the interleukin 2 receptor (IL2R) system: Jak3 as a potential molecular target for treatment of leukemias with a hyperactive Jak-Stat signaling machinery.
    Witthuhn BA; Williams MD; Kerawalla H; Uckun FM
    Leuk Lymphoma; 1999 Jan; 32(3-4):289-97. PubMed ID: 10037026
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Eleven novel JAK3 mutations in patients with severe combined immunodeficiency-including the first patients with mutations in the kinase domain.
    Mella P; Schumacher RF; Cranston T; de Saint Basile G; Savoldi G; Notarangelo LD
    Hum Mutat; 2001 Oct; 18(4):355-6. PubMed ID: 11668621
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.