BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

199 related articles for article (PubMed ID: 7981013)

  • 1. Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms.
    Andersson T; Miners JO; Veronese ME; Birkett DJ
    Br J Clin Pharmacol; 1994 Aug; 38(2):131-7. PubMed ID: 7981013
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4'-hydroxylation.
    Yasumori T; Li QH; Yamazoe Y; Ueda M; Tsuzuki T; Kato R
    Pharmacogenetics; 1994 Dec; 4(6):323-31. PubMed ID: 7704038
    [TBL] [Abstract][Full Text] [Related]  

  • 3. In vitro proguanil activation to cycloguanil by human liver microsomes is mediated by CYP3A isoforms as well as by S-mephenytoin hydroxylase.
    Birkett DJ; Rees D; Andersson T; Gonzalez FJ; Miners JO; Veronese ME
    Br J Clin Pharmacol; 1994 May; 37(5):413-20. PubMed ID: 8054246
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Diazepam metabolism by rat and human liver in vitro: inhibition by mephenytoin.
    Beischlag TV; Kalow W; Mahon WA; Inaba T
    Xenobiotica; 1992 May; 22(5):559-67. PubMed ID: 1413871
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Catalytic role of cytochrome P4502B6 in the N-demethylation of S-mephenytoin.
    Heyn H; White RB; Stevens JC
    Drug Metab Dispos; 1996 Sep; 24(9):948-54. PubMed ID: 8886603
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Identification of cytochrome P450 isoforms involved in citalopram N-demethylation by human liver microsomes.
    Kobayashi K; Chiba K; Yagi T; Shimada N; Taniguchi T; Horie T; Tani M; Yamamoto T; Ishizaki T; Kuroiwa Y
    J Pharmacol Exp Ther; 1997 Feb; 280(2):927-33. PubMed ID: 9023308
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Halofantrine metabolism in microsomes in man: major role of CYP 3A4 and CYP 3A5.
    Baune B; Flinois JP; Furlan V; Gimenez F; Taburet AM; Becquemont L; Farinotti R
    J Pharm Pharmacol; 1999 Apr; 51(4):419-26. PubMed ID: 10385214
    [TBL] [Abstract][Full Text] [Related]  

  • 8. In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.
    Tachibana S; Fujimaki Y; Yokoyama H; Okazaki O; Sudo K
    Drug Metab Dispos; 2005 Nov; 33(11):1628-36. PubMed ID: 16049129
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: role of CYP2B6, 2C19 and the 3A subfamily.
    Ono S; Hatanaka T; Miyazawa S; Tsutsui M; Aoyama T; Gonzalez FJ; Satoh T
    Xenobiotica; 1996 Nov; 26(11):1155-66. PubMed ID: 8948091
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides.
    Wright JD; Helsby NA; Ward SA
    Br J Clin Pharmacol; 1995 Apr; 39(4):441-4. PubMed ID: 7640152
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms.
    Coller JK; Somogyi AA; Bochner F
    Br J Clin Pharmacol; 1999 Aug; 48(2):158-67. PubMed ID: 10417492
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Formation of (R)-8-hydroxywarfarin in human liver microsomes. A new metabolic marker for the (S)-mephenytoin hydroxylase, P4502C19.
    Wienkers LC; Wurden CJ; Storch E; Kunze KL; Rettie AE; Trager WF
    Drug Metab Dispos; 1996 May; 24(5):610-4. PubMed ID: 8723744
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations.
    Lasker JM; Wester MR; Aramsombatdee E; Raucy JL
    Arch Biochem Biophys; 1998 May; 353(1):16-28. PubMed ID: 9578596
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cytochrome P450IIIA enzymes in rat liver microsomes: involvement in C3-hydroxylation of diazepam and nordazepam but not N-dealkylation of diazepam and temazepam.
    Reilly PE; Thompson DA; Mason SR; Hooper WD
    Mol Pharmacol; 1990 May; 37(5):767-74. PubMed ID: 1971091
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The role of CYP2C in the in vitro bioactivation of the contraceptive steroid desogestrel.
    Gentile DM; Verhoeven CH; Shimada T; Back DJ
    J Pharmacol Exp Ther; 1998 Dec; 287(3):975-82. PubMed ID: 9864282
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives.
    Shou M; Mei Q; Ettore MW; Dai R; Baillie TA; Rushmore TH
    Biochem J; 1999 Jun; 340 ( Pt 3)(Pt 3):845-53. PubMed ID: 10359672
    [TBL] [Abstract][Full Text] [Related]  

  • 17. CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.
    Ramírez J; Innocenti F; Schuetz EG; Flockhart DA; Relling MV; Santucci R; Ratain MJ
    Drug Metab Dispos; 2004 Sep; 32(9):930-6. PubMed ID: 15319333
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2.
    Yoshimoto K; Echizen H; Chiba K; Tani M; Ishizaki T
    Br J Clin Pharmacol; 1995 Apr; 39(4):421-31. PubMed ID: 7640150
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.
    Karam WG; Goldstein JA; Lasker JM; Ghanayem BI
    Drug Metab Dispos; 1996 Oct; 24(10):1081-7. PubMed ID: 8894508
    [TBL] [Abstract][Full Text] [Related]  

  • 20. In vitro metabolism of the biguanide antimalarials in human liver microsomes: evidence for a role of the mephenytoin hydroxylase (P450 MP) enzyme.
    Helsby NA; Ward SA; Howells RE; Breckenridge AM
    Br J Clin Pharmacol; 1990 Aug; 30(2):287-91. PubMed ID: 2206791
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.