170 related articles for article (PubMed ID: 8069234)
1. Slow-binding inhibition of sialidase from influenza virus.
Pegg MS; von Itzstein M
Biochem Mol Biol Int; 1994 Apr; 32(5):851-8. PubMed ID: 8069234
[TBL] [Abstract][Full Text] [Related]
2. 2,3-didehydro-2,4-dideoxy-4-guanidino-N-acetyl-D-neuraminic acid (4-guanidino-Neu5Ac2en) is a slow-binding inhibitor of sialidase from both influenza A virus and influenza B virus.
Hart GJ; Bethell RC
Biochem Mol Biol Int; 1995 Jul; 36(4):695-703. PubMed ID: 8528132
[TBL] [Abstract][Full Text] [Related]
3. Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 2. Crystallographic and molecular modeling study of complexes of 4-amino-4H-pyran-6-carboxamides and sialidase from influenza virus types A and B.
Taylor NR; Cleasby A; Singh O; Skarzynski T; Wonacott AJ; Smith PW; Sollis SL; Howes PD; Cherry PC; Bethell R; Colman P; Varghese J
J Med Chem; 1998 Mar; 41(6):798-807. PubMed ID: 9526556
[TBL] [Abstract][Full Text] [Related]
4. Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en.
Blick TJ; Tiong T; Sahasrabudhe A; Varghese JN; Colman PM; Hart GJ; Bethell RC; McKimm-Breschkin JL
Virology; 1995 Dec; 214(2):475-84. PubMed ID: 8553549
[TBL] [Abstract][Full Text] [Related]
5. Dihydropyrancarboxamides related to zanamivir: a new series of inhibitors of influenza virus sialidases. 1. Discovery, synthesis, biological activity, and structure-activity relationships of 4-guanidino- and 4-amino-4H-pyran-6-carboxamides.
Smith PW; Sollis SL; Howes PD; Cherry PC; Starkey ID; Cobley KN; Weston H; Scicinski J; Merritt A; Whittington A; Wyatt P; Taylor N; Green D; Bethell R; Madar S; Fenton RJ; Morley PJ; Pateman T; Beresford A
J Med Chem; 1998 Mar; 41(6):787-97. PubMed ID: 9526555
[TBL] [Abstract][Full Text] [Related]
6. Inhibition of replication of avian influenza viruses by the neuraminidase inhibitor 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid.
Gubareva LV; Penn CR; Webster RG
Virology; 1995 Oct; 212(2):323-30. PubMed ID: 7571401
[TBL] [Abstract][Full Text] [Related]
7. A novel synthetic reversible inhibitor of sialidase efficiently blocks secondary but not primary influenza virus infection of MDCK cells in culture.
Barrère B; Driguez PA; Maudrin J; Doutheau A; Aymard M; Quash G
Arch Virol; 1997; 142(7):1365-80. PubMed ID: 9267449
[TBL] [Abstract][Full Text] [Related]
8. Mutations affecting the sensitivity of the influenza virus neuraminidase to 4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid.
Goto H; Bethell RC; Kawaoka Y
Virology; 1997 Nov; 238(2):265-72. PubMed ID: 9400599
[TBL] [Abstract][Full Text] [Related]
9. Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2en.
Staschke KA; Colacino JM; Baxter AJ; Air GM; Bansal A; Hornback WJ; Munroe JE; Laver WG
Virology; 1995 Dec; 214(2):642-6. PubMed ID: 8553569
[TBL] [Abstract][Full Text] [Related]
10. Zanamivir. A potent and selective inhibitor of influenza A and B viruses.
Aoki FY; Hayden FG
Clin Pharmacokinet; 1999; 36 Suppl 1():v-ix. PubMed ID: 10429834
[No Abstract] [Full Text] [Related]
11. Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase.
Varghese JN; Epa VC; Colman PM
Protein Sci; 1995 Jun; 4(6):1081-7. PubMed ID: 7549872
[TBL] [Abstract][Full Text] [Related]
12. Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase.
Watson KG; Cameron R; Fenton RJ; Gower D; Hamilton S; Jin B; Krippner GY; Luttick A; McConnell D; MacDonald SJ; Mason AM; Nguyen V; Tucker SP; Wu WY
Bioorg Med Chem Lett; 2004 Mar; 14(6):1589-92. PubMed ID: 15006410
[TBL] [Abstract][Full Text] [Related]
13. Rational design of potent sialidase-based inhibitors of influenza virus replication.
von Itzstein M; Wu WY; Kok GB; Pegg MS; Dyason JC; Jin B; Van Phan T; Smythe ML; White HF; Oliver SW
Nature; 1993 Jun; 363(6428):418-23. PubMed ID: 8502295
[TBL] [Abstract][Full Text] [Related]
14. 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro.
Woods JM; Bethell RC; Coates JA; Healy N; Hiscox SA; Pearson BA; Ryan DM; Ticehurst J; Tilling J; Walcott SM
Antimicrob Agents Chemother; 1993 Jul; 37(7):1473-9. PubMed ID: 8363379
[TBL] [Abstract][Full Text] [Related]
15. Synthesis and influenza virus sialidase inhibitory activity of analogues of 4-Guanidino-Neu5Ac2en (Zanamivir) modified in the glycerol side-chain.
Andrews DM; Cherry PC; Humber DC; Jones PS; Keeling SP; Martin PF; Shaw CD; Swanson S
Eur J Med Chem; 1999; 34(7-8):563-74. PubMed ID: 11278042
[TBL] [Abstract][Full Text] [Related]
16. Sialidase activity of influenza A virus in an endocytic pathway enhances viral replication.
Suzuki T; Takahashi T; Guo CT; Hidari KI; Miyamoto D; Goto H; Kawaoka Y; Suzuki Y
J Virol; 2005 Sep; 79(18):11705-15. PubMed ID: 16140748
[TBL] [Abstract][Full Text] [Related]
17. Genetic analysis reveals that both haemagglutinin and neuraminidase determine the sensitivity of naturally occurring avian influenza viruses to zanamivir in vitro.
Baigent SJ; Bethell RC; McCauley JW
Virology; 1999 Oct; 263(2):323-38. PubMed ID: 10544106
[TBL] [Abstract][Full Text] [Related]
18. A novel means of identifying the neuraminidase type of currently circulating human A(H1) influenza viruses.
Hurt AC; Barr IG; Komadina N; Hampson AW
Virus Res; 2004 Jul; 103(1-2):79-83. PubMed ID: 15163493
[TBL] [Abstract][Full Text] [Related]
19. The synthesis of 2,3-didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid: a potent influenza virus sialidase inhibitor.
von Itzstein M; Wu WY; Jin B
Carbohydr Res; 1994 Jun; 259(2):301-5. PubMed ID: 8050102
[No Abstract] [Full Text] [Related]
20. Zanamivir: from drug design to the clinic.
Elliott M
Philos Trans R Soc Lond B Biol Sci; 2001 Dec; 356(1416):1885-93. PubMed ID: 11779388
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
