These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

371 related articles for article (PubMed ID: 8078495)

  • 1. Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
    Hasler JA; Harlow GR; Szklarz GD; John GH; Kedzie KM; Burnett VL; He YA; Kaminsky LS; Halpert JR
    Mol Pharmacol; 1994 Aug; 46(2):338-45. PubMed ID: 8078495
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
    Liu J; He YA; Halpert JR
    Arch Biochem Biophys; 1996 Mar; 327(1):167-73. PubMed ID: 8615687
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1, and 2B5.
    John GH; Hasler JA; He YA; Halpert JR
    Arch Biochem Biophys; 1994 Nov; 314(2):367-75. PubMed ID: 7979377
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
    Szklarz GD; He YQ; Kedzie KM; Halpert JR; Burnett VL
    Arch Biochem Biophys; 1996 Mar; 327(2):308-18. PubMed ID: 8619620
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
    He YQ; Szklarz GD; Halpert JR
    Arch Biochem Biophys; 1996 Nov; 335(1):152-60. PubMed ID: 8914846
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase.
    Harlow GR; Halpert JR
    Arch Biochem Biophys; 1996 Feb; 326(1):85-92. PubMed ID: 8579377
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11.
    Waller SC; He YA; Harlow GR; He YQ; Mash EA; Halpert JR
    Chem Res Toxicol; 1999 Aug; 12(8):690-9. PubMed ID: 10458702
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.
    He YQ; Harlow GR; Szklarz GD; Halpert JR
    Arch Biochem Biophys; 1998 Feb; 350(2):333-9. PubMed ID: 9473309
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Characterization of the progesterone 21-hydroxylase activity of canine cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous expression, and site-directed mutagenesis.
    Born SL; John GH; Harlow GR; Halpert JR
    Drug Metab Dispos; 1995 Jul; 23(7):702-7. PubMed ID: 7587957
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure-function analysis of human cytochrome P-450 2B6 using a novel substrate, site-directed mutagenesis, and molecular modeling.
    Domanski TL; Schultz KM; Roussel F; Stevens JC; Halpert JR
    J Pharmacol Exp Ther; 1999 Sep; 290(3):1141-7. PubMed ID: 10454488
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
    Luo Z; He YA; Halpert JR
    Arch Biochem Biophys; 1994 Feb; 309(1):52-7. PubMed ID: 8117113
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.
    He YA; He YQ; Szklarz GD; Halpert JR
    Biochemistry; 1997 Jul; 36(29):8831-9. PubMed ID: 9220969
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Reassessment of cytochrome P450 2B2: catalytic specificity and identification of four active site residues.
    Strobel SM; Halpert JR
    Biochemistry; 1997 Sep; 36(39):11697-706. PubMed ID: 9305959
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11.
    Harlow GR; He YA; Halpert JR
    Biochim Biophys Acta; 1997 Apr; 1338(2):259-66. PubMed ID: 9128144
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites.
    He Y; Luo Z; Klekotka PA; Burnett VL; Halpert JR
    Biochemistry; 1994 Apr; 33(14):4419-24. PubMed ID: 8155660
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies.
    He YQ; He YA; Halpert JR
    Chem Res Toxicol; 1995 Jun; 8(4):574-9. PubMed ID: 7548737
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity.
    Straub P; Johnson EF; Kemper B
    Arch Biochem Biophys; 1993 Nov; 306(2):521-7. PubMed ID: 8215458
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Catalytic selectivity and mechanism-based inactivation of stably expressed and hepatic cytochromes P450 2B4 and 2B5: implications of the cytochrome P450 2B5 polymorphism.
    Grimm SW; Dyroff MC; Philpot RM; Halpert JR
    Mol Pharmacol; 1994 Dec; 46(6):1090-9. PubMed ID: 7808429
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics.
    Chen CS; Lin JT; Goss KA; He YA; Halpert JR; Waxman DJ
    Mol Pharmacol; 2004 May; 65(5):1278-85. PubMed ID: 15102956
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes.
    He YQ; Roussel F; Halpert JR
    Arch Biochem Biophys; 2001 May; 389(2):264-70. PubMed ID: 11339816
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.