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4. Effects of alkyl substitutions of xanthine skeleton on bronchodilation. Sakai R; Konno K; Yamamoto Y; Sanae F; Takagi K; Hasegawa T; Iwasaki N; Kakiuchi M; Kato H; Miyamoto K J Med Chem; 1992 Oct; 35(22):4039-44. PubMed ID: 1331453 [TBL] [Abstract][Full Text] [Related]
5. Bronchodilator activity of xanthine derivatives substituted with functional groups at the 1- or 7-position. Miyamoto K; Yamamoto Y; Kurita M; Sakai R; Konno K; Sanae F; Ohshima T; Takagi K; Hasegawa T; Iwasaki N J Med Chem; 1993 May; 36(10):1380-6. PubMed ID: 8496906 [TBL] [Abstract][Full Text] [Related]
6. Modulation of relaxant responses evoked by a nitric oxide donor and by nonadrenergic, noncholinergic stimulation by isozyme-selective phosphodiesterase inhibitors in guinea pig trachea. Ellis JL; Conanan ND J Pharmacol Exp Ther; 1995 Mar; 272(3):997-1004. PubMed ID: 7891355 [TBL] [Abstract][Full Text] [Related]
7. Relaxant effects of various xanthine derivatives. Relationship to cyclic nucleotide phosphodiesterase inhibition. Takagi K; Ogawa K; Tanaka H; Satake T; Watanabe Y; Chijiwa T; Hidaka H Adv Second Messenger Phosphoprotein Res; 1992; 25():353-62. PubMed ID: 1313267 [No Abstract] [Full Text] [Related]
8. Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus. Cortijo J; Bou J; Beleta J; Cardelús I; Llenas J; Morcillo E; Gristwood RW Br J Pharmacol; 1993 Feb; 108(2):562-8. PubMed ID: 8383567 [TBL] [Abstract][Full Text] [Related]
9. Mechanism of xanthine-induced relaxation of guinea-pig isolated trachealis muscle. Ogawa K; Takagi K; Satake T Br J Pharmacol; 1989 Jun; 97(2):542-6. PubMed ID: 2547475 [TBL] [Abstract][Full Text] [Related]
10. Phosphodiesterase 4 inhibitors as airways smooth muscle relaxant agents: synthesis and biological activities of triazine derivatives. Leroux F; van Keulen BJ; Daliers J; Pommery N; Hénichart JP Bioorg Med Chem; 1999 Mar; 7(3):509-16. PubMed ID: 10220036 [TBL] [Abstract][Full Text] [Related]
11. Structure-activity relationships of alkylxanthines: alkyl chain elongation at the N1- or N7-position decreases cardiotonic activity in the isolated guinea pig heart. Sanae F; Ohmae S; Kurita M; Sawanishi H; Takagi K; Miyamoto K Jpn J Pharmacol; 1995 Oct; 69(2):75-82. PubMed ID: 8569057 [TBL] [Abstract][Full Text] [Related]
12. Cyclic nucleotide phosphodiesterase isoenzymes in guinea-pig tracheal muscle and bronchorelaxation by alkylxanthines. Miyamoto K; Kurita M; Sakai R; Sanae F; Wakusawa S; Takagi K Biochem Pharmacol; 1994 Sep; 48(6):1219-23. PubMed ID: 7945415 [TBL] [Abstract][Full Text] [Related]