BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

116 related articles for article (PubMed ID: 8120864)

  • 1. Antitumor agents. 148. Synthesis and biological evaluation of novel 4 beta-amino derivatives of etoposide with better pharmacological profiles.
    Zhang YL; Guo X; Cheng YC; Lee KH
    J Med Chem; 1994 Feb; 37(4):446-52. PubMed ID: 8120864
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Antitumor agents. 123. Synthesis and human DNA topoisomerase II inhibitory activity of 2'-chloro derivatives of etoposide and 4 beta-(arylamino)-4'-O-demethylpodophyllotoxins.
    Hu H; Wang ZQ; Liu SY; Cheng YC; Lee KH
    J Med Chem; 1992 Mar; 35(5):866-71. PubMed ID: 1312600
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Antitumor agents. 194. Synthesis and biological evaluations of 4-beta-mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles.
    Zhu XK; Guan J; Tachibana Y; Bastow KF; Cho SJ; Cheng HH; Cheng YC; Gurwith M; Lee KH
    J Med Chem; 1999 Jul; 42(13):2441-6. PubMed ID: 10395485
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Antitumor agents. Part 235: Novel 4'-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential.
    Xiao Z; Vance JR; Bastow KF; Brossi A; Wang HK; Lee KH
    Bioorg Med Chem; 2004 Jun; 12(12):3363-9. PubMed ID: 15158805
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Antitumor agents 210. Synthesis and evaluation of taxoid-epipodophyllotoxin conjugates as novel cytotoxic agents.
    Shi Q; Wang HK; Bastow KF; Tachibana Y; Chen K; Lee FY; Lee KH
    Bioorg Med Chem; 2001 Nov; 9(11):2999-3004. PubMed ID: 11597482
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Antitumor agents. 124. New 4 beta-substituted aniline derivatives of 6,7-O,O-demethylene-4'-O-demethylpodophyllotoxin and related compounds as potent inhibitors of human DNA topoisomerase II.
    Wang ZQ; Hu H; Chen HX; Cheng YC; Lee KH
    J Med Chem; 1992 Mar; 35(5):871-7. PubMed ID: 1312601
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs.
    Yadav AA; Chee GL; Wu X; Patel D; Yalowich JC; Hasinoff BB
    Bioorg Med Chem; 2015 Jul; 23(13):3542-51. PubMed ID: 25922181
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel ciprofloxacin hybrids using biology oriented drug synthesis (BIODS) approach: Anticancer activity, effects on cell cycle profile, caspase-3 mediated apoptosis, topoisomerase II inhibition, and antibacterial activity.
    Kassab AE; Gedawy EM
    Eur J Med Chem; 2018 Apr; 150():403-418. PubMed ID: 29547830
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Chemical synthesis and biological activity of a novel fluorescent etoposide derivative.
    Lazo JS; Li T; Woo ES; Settineri CE; Allan WP; Yalowich JC
    Biochem Pharmacol; 1997 Mar; 53(5):715-22. PubMed ID: 9113091
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors.
    Han S; Xiao Z; Bastow KF; Lee KH
    Bioorg Med Chem Lett; 2004 Jun; 14(11):2979-82. PubMed ID: 15125972
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Antitumor agents. 144. New gamma-lactone ring-modified arylamino etoposide analogs as inhibitors of human DNA topoisomerase II.
    Zhou XM; Lee KJ; Cheng J; Wu SS; Chen HX; Guo X; Cheng YC; Lee KH
    J Med Chem; 1994 Jan; 37(2):287-92. PubMed ID: 8295216
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Antitumor agents. 3. Synthesis and biological activity of 4 beta-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents.
    Terada T; Fujimoto K; Nomura M; Yamashita J; Wierzba K; Yamazaki R; Shibata J; Sugimoto Y; Yamada Y; Kobunai T
    J Med Chem; 1993 Jun; 36(12):1689-99. PubMed ID: 8389875
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Antitumor agents. 125. New 4 beta-benzoylamino derivatives of 4'-O-demethyl-4-desoxypodophyllotoxin and 4 beta-benzoyl derivatives of 4'-O-demethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
    Zhou XM; Wang ZQ; Chen HX; Cheng YC; Lee KH
    Pharm Res; 1993 Feb; 10(2):214-9. PubMed ID: 8384366
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4beta-[(4' '-benzamido)-amino]-4'-o-demethyl-epipodophyllotoxin derivatives.
    Xiao Z; Bastow KF; Vance JR; Sidwell RS; Wang HK; Chen MS; Shi Q; Lee KH
    J Med Chem; 2004 Oct; 47(21):5140-8. PubMed ID: 15456257
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Etoposide: discovery and medicinal chemistry.
    Meresse P; Dechaux E; Monneret C; Bertounesque E
    Curr Med Chem; 2004 Sep; 11(18):2443-66. PubMed ID: 15379707
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Antitumor agents. 111. New 4-hydroxylated and 4-halogenated anilino derivatives of 4'-demethylepipodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
    Lee KH; Beers SA; Mori M; Wang ZQ; Kuo YH; Li L; Liu SY; Chang JY; Han FS; Cheng YC
    J Med Chem; 1990 May; 33(5):1364-8. PubMed ID: 2158562
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Antitumor agents. 164. Podophenazine, 2'',3''-dichloropodophenazine, benzopodophenazine, and their 4 beta-p-nitroaniline derivatives as novel DNA topoisomerase II inhibitors.
    Cho SJ; Kashiwada Y; Bastow KF; Cheng YC; Lee KH
    J Med Chem; 1996 Mar; 39(7):1396-402. PubMed ID: 8691469
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and biological evaluation of 2-phenol-4-chlorophenyl-6-aryl pyridines as topoisomerase II inhibitors and cytotoxic agents.
    Thapa P; Kadayat TM; Park S; Shin S; Thapa Magar TB; Bist G; Shrestha A; Na Y; Kwon Y; Lee ES
    Bioorg Chem; 2016 Jun; 66():145-59. PubMed ID: 27174797
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation.
    Zhao W; Chen L; Li HM; Wang DJ; Li DS; Chen T; Yuan ZP; Tang YJ
    Bioorg Med Chem; 2014 Jun; 22(11):2998-3007. PubMed ID: 24775914
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Antitumor agents. 126. Novel 4 beta-substituted anilino derivatives of 3',4'-O,O-didemethylpodophyllotoxin as potent inhibitors of human DNA topoisomerase II.
    Wang ZQ; Shen YC; Chen HX; Chang JY; Guo X; Cheng YC; Lee KH
    Pharm Res; 1993 Mar; 10(3):343-50. PubMed ID: 8385331
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.