These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

97 related articles for article (PubMed ID: 812990)

  • 1. Podophyllotoxin analogs. 1. Synthesis and biological evaluation of certain trans-2-aryl-trans-6-hydroxymethyl-3-cyclohexenecarboxylic acid gamma-lactones as antimitotic agents.
    Smissman EE; Murray RJ; McChesney JD; Houston LL; Pazdernik TL
    J Med Chem; 1976 Jan; 19(1):148-53. PubMed ID: 812990
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Methylenedioxy-benzopyran analogs of podophyllotoxin, a new synthetic class of antimitotic agents that inhibit tubulin polymerization.
    Batra JK; Kang GJ; Jurd L; Hamel E
    Biochem Pharmacol; 1988 Jul; 37(13):2595-602. PubMed ID: 3390218
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Correlation of tubulin-binding and antitumor activities of podophyllotoxin analogs.
    Kelleher JK
    Cancer Treat Rep; 1978 Oct; 62(10):1443-7. PubMed ID: 101303
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Tubulin binding affinities of podophyllotoxin and colchicine analogues.
    Kelleher JK
    Mol Pharmacol; 1977 Mar; 13(2):232-41. PubMed ID: 854021
    [No Abstract]   [Full Text] [Related]  

  • 5. Antimitotic and antitubulin activity of the tumor inhibitor steganacin.
    Wang RW; Rebhum LI; Kupchan SM
    Cancer Res; 1977 Sep; 37(9):3071-9. PubMed ID: 560248
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural and Biochemical Characterization of the Interaction of Tubulin with Potent Natural Analogues of Podophyllotoxin.
    Antúnez-Mojica M; Rodríguez-Salarichs J; Redondo-Horcajo M; León A; Barasoain I; Canales Á; Cañada FJ; Jiménez-Barbero J; Alvarez L; Díaz JF
    J Nat Prod; 2016 Aug; 79(8):2113-21. PubMed ID: 27518758
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin.
    Lin CM; Ho HH; Pettit GR; Hamel E
    Biochemistry; 1989 Aug; 28(17):6984-91. PubMed ID: 2819042
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Morpholino derivatives of benzyl-benzodioxole, a study of structural requirements for drug interactions at the colchicine/podophyllotoxin binding site of tubulin.
    Batra JK; Jurd L; Hamel E
    Biochem Pharmacol; 1986 Nov; 35(22):4013-8. PubMed ID: 3778522
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discover 4β-NH-(6-aminoindole)-4-desoxy-podophyllotoxin with nanomolar-potency antitumor activity by improving the tubulin binding affinity on the basis of a potential binding site nearby colchicine domain.
    Zhao W; He L; Xiang TL; Tang YJ
    Eur J Med Chem; 2019 May; 170():73-86. PubMed ID: 30878833
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Structure--antitubulin activity relationship in steganacin congeners and analogues. Inhibition of tubulin polymerization in vitro by (+/-)-isodeoxypodophyllotoxin.
    Zavala F; Guenard D; Robin JP; Brown E
    J Med Chem; 1980 May; 23(5):546-9. PubMed ID: 7381854
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Mechanism of binding of the new antimitotic drug MDL 27048 to the colchicine site of tubulin: equilibrium studies.
    Peyrot V; Leynadier D; Sarrazin M; Briand C; Menendez M; Laynez J; Andreu JM
    Biochemistry; 1992 Nov; 31(45):11125-32. PubMed ID: 1445852
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Oxalone and lactone moieties of podophyllotoxin exhibit properties of both the B and C rings of colchicine in its binding with tubulin.
    Gupta S; Das L; Datta AB; Poddar A; Janik ME; Bhattacharyya B
    Biochemistry; 2006 May; 45(20):6467-75. PubMed ID: 16700557
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.
    Lin CM; Singh SB; Chu PS; Dempcy RO; Schmidt JM; Pettit GR; Hamel E
    Mol Pharmacol; 1988 Aug; 34(2):200-8. PubMed ID: 3412321
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Binding of colchicine to beef brain tubulin: influence of methodology on binding constants.
    Luyckx M; Brunet C; Cazin M
    Methods Find Exp Clin Pharmacol; 1984 Nov; 6(11):679-84. PubMed ID: 6530906
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effect of an epipodophyllotoxin derivative (VP 16-213) on macromolecular synthesis and mitosis in mastocytoma cells in vitro.
    Grieder A; Maurer R; Stähelin H
    Cancer Res; 1974 Aug; 34(8):1788-93. PubMed ID: 4210356
    [No Abstract]   [Full Text] [Related]  

  • 16. Action of drugs on microtubules.
    Wilson L
    Life Sci; 1975 Aug; 17(3):303-9. PubMed ID: 1099380
    [No Abstract]   [Full Text] [Related]  

  • 17. Structure-function studies with derivatives of 6-benzyl-1,3-benzodioxole, a new class of synthetic compounds which inhibit tubulin polymerization and mitosis.
    Batra JK; Jurd L; Hamel E
    Mol Pharmacol; 1985 Jan; 27(1):94-102. PubMed ID: 3965931
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.
    Cushman M; He HM; Katzenellenbogen JA; Lin CM; Hamel E
    J Med Chem; 1995 Jun; 38(12):2041-9. PubMed ID: 7783135
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Interaction of tubulin with drugs and alkylating agents. 2. Effects of colchicine, podophyllotoxin, and vinblastine on the alkylation of tubulin.
    Ludueña RF; Roach MC
    Biochemistry; 1981 Jul; 20(15):4444-50. PubMed ID: 7284334
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Nonenolizable podophyllotoxin derivatives.
    Gensler WJ; Murthy CD; Trammell MH
    J Med Chem; 1977 May; 20(5):635-44. PubMed ID: 853503
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 5.