BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

170 related articles for article (PubMed ID: 8137289)

  • 1. Effect of 9-benzyl-9-deazaguanine, a potent inhibitor of purine nucleoside phosphorylase, on the cytotoxicity and metabolism of 6-thio-2'-deoxyguanosine.
    Parker WB; Allan PW; Niwas S; Montgomery JA; Bennett LL
    Cancer Res; 1994 Apr; 54(7):1742-5. PubMed ID: 8137289
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Purine nucleoside phosphorylase inhibitors: biochemical and pharmacological studies with 9-benzyl-9-deazaguanine and related compounds.
    Bennett LL; Allan PW; Noker PE; Rose LM; Niwas S; Montgomery JA; Erion MD
    J Pharmacol Exp Ther; 1993 Aug; 266(2):707-14. PubMed ID: 8355201
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Potentiation of 2'-deoxyguanosine cytotoxicity by a novel inhibitor of purine nucleoside phosphorylase, 8-amino-9-benzylguanine.
    Shewach DS; Chern JW; Pillote KE; Townsend LB; Daddona PE
    Cancer Res; 1986 Feb; 46(2):519-23. PubMed ID: 3079664
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Mechanism of inhibition of T-acute lymphoblastic leukemia cells by PNP inhibitor--BCX-1777.
    Bantia S; Ananth SL; Parker CD; Horn LL; Upshaw R
    Int Immunopharmacol; 2003 Jun; 3(6):879-87. PubMed ID: 12781704
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional and mechanistic studies on the toxicity of deoxyguanosine for the in vitro proliferation and differentiation of human peripheral blood B lymphocytes.
    Scharenberg JG; Spaapen LJ; Rijkers GT; Duran M; Staal GE; Zegers BJ
    Eur J Immunol; 1986 Apr; 16(4):381-7. PubMed ID: 3084280
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes--a novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies.
    Bantia S; Parker C; Upshaw R; Cunningham A; Kotian P; Kilpatrick JM; Morris P; Chand P; Babu YS
    Int Immunopharmacol; 2010 Jul; 10(7):784-90. PubMed ID: 20399911
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Mechanisms of deoxyguanosine lymphotoxicity. Human thymocytes, but not peripheral blood lymphocytes accumulate deoxy-GTP in conditions simulating purine nucleoside phosphorylase deficiency.
    Fairbanks LD; Taddeo A; Duley JA; Simmonds HA
    J Immunol; 1990 Jan; 144(2):485-91. PubMed ID: 2104895
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The biochemistry and pharmacology of PD 116124 (8-amino-2'-nordeoxyguanosine), an inhibitor of purine nucleoside phosphorylase (PNP).
    Dong MK; Scott ME; Schrier DJ; Suto MJ; Sircar JC; Black A; Chang T; Gilbertsen RB
    J Pharmacol Exp Ther; 1992 Jan; 260(1):319-26. PubMed ID: 1530976
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effects of guanine ribonucleotide accumulation on the metabolism and cell cycle of human lymphoid cells.
    Sidi Y; Hudson JL; Mitchell BS
    Cancer Res; 1985 Oct; 45(10):4940-5. PubMed ID: 2411392
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The effect of deoxyguanosine on human lymphocyte function. II. Analysis of the interference with B lymphocyte differentiation in vitro.
    Spaapen LJ; Rijkers GT; Staal GE; Rijksen G; Duran M; Stoop JW; Zegers BJ
    J Immunol; 1984 May; 132(5):2318-23. PubMed ID: 6425400
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Purine nucleoside phosphorylase inhibitors in T-cell malignancies.
    Bantia S; Kilpatrick JM
    Curr Opin Drug Discov Devel; 2004 Mar; 7(2):243-7. PubMed ID: 15603259
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A purine nucleoside phosphorylase (PNP) inhibitor induces apoptosis via caspase-3-like protease activity in MOLT-4 T cells.
    Posmantur R; Wang KK; Nath R; Gilbertsen RB
    Immunopharmacology; 1997 Oct; 37(2-3):231-44. PubMed ID: 9403342
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Low dose of deoxyguanosine increases IL-2 receptors of IL-2-dependent cultured T cells.
    Noma T; Klein B; Yata J; Serrou B
    Immunology; 1984 Jun; 52(2):247-52. PubMed ID: 6610631
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of purine nucleoside phosphorylase deficiency on thymocyte development.
    Papinazath T; Min W; Sujiththa S; Cohen A; Ackerley C; Roifman CM; Grunebaum E
    J Allergy Clin Immunol; 2011 Oct; 128(4):854-863.e1. PubMed ID: 21868080
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Preliminary report on 8-amino-9-(2-thienylmethyl)guanine (PD 119,229), a novel and potent purine nucleoside phosphorylase inhibitor.
    Gilbertsen RB; Scott ME; Dong MK; Kossarek LM; Bennett MK; Schrier DJ; Sircar JC
    Agents Actions; 1987 Aug; 21(3-4):272-4. PubMed ID: 3120507
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Drug evaluation: forodesine - PNP inhibitor for the treatment of leukemia, lymphoma and solid tumor.
    Galmarini CM
    IDrugs; 2006 Oct; 9(10):712-22. PubMed ID: 17016779
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Phosphorylation of deoxyguanosine by B and T lymphocytes: evidence against selective trapping of deoxyguanosine by T lymphocytes in purine nucleoside phosphorylase deficiency.
    North ME; Newton CA; Webster AD
    Clin Exp Immunol; 1980 Dec; 42(3):523-9. PubMed ID: 6783354
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Different pathways for deoxyguanosine toxicity in T-lymphocytes of various developmental stages.
    Scharenberg JG; Rijkers GT; Spaapen LJ; Toebes EA; Rijksen G; Duran M; Staal GE; Zegers BJ
    Int J Immunopharmacol; 1988; 10(6):675-86. PubMed ID: 2974022
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The biochemical and pharmacological activity of 9-benzyl-9-deazaguanine, a potent purine nucleoside phosphorylase (PNP) inhibitor.
    Kimble E; Hadala J; Ludewig R; Peters P; Greenberg G; Xiao G; Guida W; McQuire L; Simon P
    Inflamm Res; 1995 Aug; 44 Suppl 2():S181-2. PubMed ID: 8548387
    [No Abstract]   [Full Text] [Related]  

  • 20. Antiproliferative activity of purine nucleoside phosphorylase multisubstrate analogue inhibitors containing difluoromethylene phosphonic acid against leukaemia and lymphoma cells.
    Glavas-Obrovac L; Suver M; Hikishima S; Hashimoto M; Yokomatsu T; Magnowska L; Bzowska A
    Chem Biol Drug Des; 2010 Apr; 75(4):392-9. PubMed ID: 20102369
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.