BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

118 related articles for article (PubMed ID: 8142888)

  • 1. Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors.
    Smith GM; Alexander RS; Christianson DW; McKeever BM; Ponticello GS; Springer JP; Randall WC; Baldwin JJ; Habecker CN
    Protein Sci; 1994 Jan; 3(1):118-25. PubMed ID: 8142888
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators.
    Temperini C; Scozzafava A; Puccetti L; Supuran CT
    Bioorg Med Chem Lett; 2005 Dec; 15(23):5136-41. PubMed ID: 16214338
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Crystal structure of carbonic anhydrase from Neisseria gonorrhoeae and its complex with the inhibitor acetazolamide.
    Huang S; Xue Y; Sauer-Eriksson E; Chirica L; Lindskog S; Jonsson BH
    J Mol Biol; 1998; 283(1):301-10. PubMed ID: 9761692
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: a pentacoordinated binding of the SCN- ion to the zinc at high pH.
    Eriksson AE; Kylsten PM; Jones TA; Liljas A
    Proteins; 1988; 4(4):283-93. PubMed ID: 3151020
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II "selective" inhibitor celecoxib.
    Di Fiore A; Pedone C; D'Ambrosio K; Scozzafava A; De Simone G; Supuran CT
    Bioorg Med Chem Lett; 2006 Jan; 16(2):437-42. PubMed ID: 16290146
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.
    Temperini C; Scozzafava A; Vullo D; Supuran CT
    Chemistry; 2006 Sep; 12(27):7057-66. PubMed ID: 16807956
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metal poison inhibition of carbonic anhydrase.
    Lindahl M; Svensson LA; Liljas A
    Proteins; 1993 Feb; 15(2):177-82. PubMed ID: 8441752
    [TBL] [Abstract][Full Text] [Related]  

  • 8. X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
    Scolnick LR; Christianson DW
    Biochemistry; 1996 Dec; 35(51):16429-34. PubMed ID: 8987974
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II.
    Menchise V; De Simone G; Di Fiore A; Scozzafava A; Supuran CT
    Bioorg Med Chem Lett; 2006 Dec; 16(24):6204-8. PubMed ID: 17000110
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme.
    Chakravarty S; Kannan KK
    J Mol Biol; 1994 Oct; 243(2):298-309. PubMed ID: 7932756
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Crystal structure of the complex between human carbonic anhydrase II and the aromatic inhibitor 1,2,4-triazole.
    Mangani S; Liljas A
    J Mol Biol; 1993 Jul; 232(1):9-14. PubMed ID: 8331673
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of two hydrophobic patches in the active-site cavity of human carbonic anhydrase II by solution-phase and solid-state studies and their use in the development of tight-binding inhibitors.
    Jain A; Whitesides GM; Alexander RS; Christianson DW
    J Med Chem; 1994 Jun; 37(13):2100-5. PubMed ID: 8027991
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Application of the free energy perturbation method to human carbonic anhydrase II inhibitors.
    Rossi KA; Merz KM; Smith GM; Baldwin JJ
    J Med Chem; 1995 Jun; 38(12):2061-9. PubMed ID: 7783137
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.
    Fisher Z; Hernandez Prada JA; Tu C; Duda D; Yoshioka C; An H; Govindasamy L; Silverman DN; McKenna R
    Biochemistry; 2005 Feb; 44(4):1097-105. PubMed ID: 15667203
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.
    Di Fiore A; Monti SM; Hilvo M; Parkkila S; Romano V; Scaloni A; Pedone C; Scozzafava A; Supuran CT; De Simone G
    Proteins; 2009 Jan; 74(1):164-75. PubMed ID: 18618712
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference.
    Temperini C; Cecchi A; Scozzafava A; Supuran CT
    Bioorg Med Chem; 2009 Feb; 17(3):1214-21. PubMed ID: 19119014
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
    Temperini C; Cecchi A; Boyle NA; Scozzafava A; Cabeza JE; Wentworth P; Blackburn GM; Supuran CT
    Bioorg Med Chem Lett; 2008 Feb; 18(3):999-1005. PubMed ID: 18162396
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II.
    Fisher SZ; Tu C; Bhatt D; Govindasamy L; Agbandje-McKenna M; McKenna R; Silverman DN
    Biochemistry; 2007 Mar; 46(12):3803-13. PubMed ID: 17330962
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural analysis of inhibitor binding to human carbonic anhydrase II.
    Boriack-Sjodin PA; Zeitlin S; Chen HH; Crenshaw L; Gross S; Dantanarayana A; Delgado P; May JA; Dean T; Christianson DW
    Protein Sci; 1998 Dec; 7(12):2483-9. PubMed ID: 9865942
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A versatile polypeptide platform for integrated recognition and reporting: affinity arrays for protein-ligand interaction analysis.
    Enander K; Dolphin GT; Liedberg B; Lundström I; Baltzer L
    Chemistry; 2004 May; 10(10):2375-85. PubMed ID: 15146511
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.