These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

120 related articles for article (PubMed ID: 8144541)

  • 1. Methotrexate-resistant variants of human dihydrofolate reductase. Effects of Phe31 substitutions.
    Chunduru SK; Cody V; Luft JR; Pangborn W; Appleman JR; Blakley RL
    J Biol Chem; 1994 Apr; 269(13):9547-55. PubMed ID: 8144541
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Methotrexate-resistant variants of human dihydrofolate reductase with substitutions of leucine 22. Kinetics, crystallography, and potential as selectable markers.
    Lewis WS; Cody V; Galitsky N; Luft JR; Pangborn W; Chunduru SK; Spencer HT; Appleman JR; Blakley RL
    J Biol Chem; 1995 Mar; 270(10):5057-64. PubMed ID: 7890613
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Kinetic investigation of methotrexate resistant human dihydrofolate reductase (hDHFR) mutants at Phe31.
    Chunduru SK; Appleman JR; Blakley RL
    Adv Exp Med Biol; 1993; 338():507-10. PubMed ID: 8304168
    [No Abstract]   [Full Text] [Related]  

  • 4. Critical role of phenylalanine 34 of human dihydrofolate reductase in substrate and inhibitor binding and in catalysis.
    Nakano T; Spencer HT; Appleman JR; Blakley RL
    Biochemistry; 1994 Aug; 33(33):9945-52. PubMed ID: 8061003
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Site-directed mutagenesis of mouse dihydrofolate reductase. Mutants with increased resistance to methotrexate and trimethoprim.
    Thillet J; Absil J; Stone SR; Pictet R
    J Biol Chem; 1988 Sep; 263(25):12500-8. PubMed ID: 3045118
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Understanding the role of Leu22 variants in methotrexate resistance: comparison of wild-type and Leu22Arg variant mouse and human dihydrofolate reductase ternary crystal complexes with methotrexate and NADPH.
    Cody V; Luft JR; Pangborn W
    Acta Crystallogr D Biol Crystallogr; 2005 Feb; 61(Pt 2):147-55. PubMed ID: 15681865
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Increasing methotrexate resistance by combination of active-site mutations in human dihydrofolate reductase.
    Volpato JP; Fossati E; Pelletier JN
    J Mol Biol; 2007 Oct; 373(3):599-611. PubMed ID: 17868689
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Probing the role of two hydrophobic active site residues in the human dihydrofolate reductase by site-directed mutagenesis.
    Schweitzer BI; Srimatkandada S; Gritsman H; Sheridan R; Venkataraghavan R; Bertino JR
    J Biol Chem; 1989 Dec; 264(34):20786-95. PubMed ID: 2684985
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Active site-directed double mutants of dihydrofolate reductase.
    Ercikan-Abali EA; Mineishi S; Tong Y; Nakahara S; Waltham MC; Banerjee D; Chen W; Sadelain M; Bertino JR
    Cancer Res; 1996 Sep; 56(18):4142-5. PubMed ID: 8797582
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Methotrexate resistance of mouse dihydrofolate reductase: effect of substitution of phenylalanine-31 by serine or tryptophan.
    Evenson DA; Adams J; McIvor RS; Wagner CR
    J Med Chem; 1996 Apr; 39(9):1763-6. PubMed ID: 8627598
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Investigation of the functional role of tryptophan-22 in Escherichia coli dihydrofolate reductase by site-directed mutagenesis.
    Warren MS; Brown KA; Farnum MF; Howell EE; Kraut J
    Biochemistry; 1991 Nov; 30(46):11092-103. PubMed ID: 1932031
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Evidence for a functional role of the dynamics of glycine-121 of Escherichia coli dihydrofolate reductase obtained from kinetic analysis of a site-directed mutant.
    Cameron CE; Benkovic SJ
    Biochemistry; 1997 Dec; 36(50):15792-800. PubMed ID: 9398309
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Multiple conformers in active site of human dihydrofolate reductase F31R/Q35E double mutant suggest structural basis for methotrexate resistance.
    Volpato JP; Yachnin BJ; Blanchet J; Guerrero V; Poulin L; Fossati E; Berghuis AM; Pelletier JN
    J Biol Chem; 2009 Jul; 284(30):20079-89. PubMed ID: 19478082
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Contributions of tryptophan 24 and glutamate 30 to binding long-lived water molecules in the ternary complex of human dihydrofolate reductase with methotrexate and NADPH studied by site-directed mutagenesis and nuclear magnetic resonance spectroscopy.
    Meiering EM; Li H; Delcamp TJ; Freisheim JH; Wagner G
    J Mol Biol; 1995 Mar; 247(2):309-25. PubMed ID: 7707377
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Controlling enzyme inhibition using an expanded set of genetically encoded amino acids.
    Zheng S; Kwon I
    Biotechnol Bioeng; 2013 Sep; 110(9):2361-70. PubMed ID: 23568807
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Effects of substitution of Thr63 by alanine on the structure and function of Lactobacillus casei dihydrofolate reductase.
    Thomas JA; Arnold JR; Basran J; Andrews J; Roberts GC; Birdsall B; Feeney J
    Protein Eng; 1994 Jun; 7(6):783-92. PubMed ID: 7937709
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Effects of conversion of phenylalanine-31 to leucine on the function of human dihydrofolate reductase.
    Prendergast NJ; Appleman JR; Delcamp TJ; Blakley RL; Freisheim JH
    Biochemistry; 1989 May; 28(11):4645-50. PubMed ID: 2765506
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Nonadditivity of mutational effects at the folate binding site of Escherichia coli dihydrofolate reductase.
    Huang Z; Wagner CR; Benkovic SJ
    Biochemistry; 1994 Sep; 33(38):11576-85. PubMed ID: 7918371
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Effects of point mutations at the flexible loop glycine-67 of Escherichia coli dihydrofolate reductase on its stability and function.
    Ohmae E; Iriyama K; Ichihara S; Gekko K
    J Biochem; 1996 Apr; 119(4):703-10. PubMed ID: 8743572
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Engineering specificity for folate into dihydrofolate reductase from Escherichia coli.
    Posner BA; Li L; Bethell R; Tsuji T; Benkovic SJ
    Biochemistry; 1996 Feb; 35(5):1653-63. PubMed ID: 8634297
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.