219 related articles for article (PubMed ID: 8161528)
1. Selective inhibition of mammalian lanosterol 14 alpha-demethylase by RS-21607 in vitro and in vivo.
Swinney DC; So OY; Watson DM; Berry PW; Webb AS; Kertesz DJ; Shelton EJ; Burton PM; Walker KA
Biochemistry; 1994 Apr; 33(15):4702-13. PubMed ID: 8161528
[TBL] [Abstract][Full Text] [Related]
2. Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity.
Burton PM; Swinney DC; Heller R; Dunlap B; Chiou M; Malonzo E; Haller J; Walker KA; Salari A; Murakami S
Biochem Pharmacol; 1995 Aug; 50(4):529-44. PubMed ID: 7646560
[TBL] [Abstract][Full Text] [Related]
3. Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol.
Tuck SF; Patel H; Safi E; Robinson CH
J Lipid Res; 1991 Jun; 32(6):893-902. PubMed ID: 1940622
[TBL] [Abstract][Full Text] [Related]
4. Cholesterol biosynthesis from lanosterol: development of a novel assay method and characterization of rat liver microsomal lanosterol delta 24-reductase.
Bae SH; Paik YK
Biochem J; 1997 Sep; 326 ( Pt 2)(Pt 2):609-16. PubMed ID: 9291139
[TBL] [Abstract][Full Text] [Related]
5. Different substrate specificities of lanosterol 14a-demethylase (P-45014DM) of Saccharomyces cerevisiae and rat liver for 24-methylene-24,25-dihydrolanosterol and 24,25-dihydrolanosterol.
Aoyama Y; Yoshida Y
Biochem Biophys Res Commun; 1991 Aug; 178(3):1064-71. PubMed ID: 1872829
[TBL] [Abstract][Full Text] [Related]
6. Regulation of hepatic cholesterol biosynthesis. Effects of a cytochrome P-450 inhibitor on the formation and metabolism of oxygenated sterol products of lanosterol.
Iglesias J; Gibbons GF
Biochem J; 1989 Dec; 264(2):495-502. PubMed ID: 2604729
[TBL] [Abstract][Full Text] [Related]
7. Purification and characterization of a cytochrome P450 isozyme catalyzing lanosterol 14 alpha-demethylation (P45014DM) in hamster liver.
Sekigawa Y; Fukuhara M; Sonoda Y; Sato Y
Lipids; 1995 Dec; 30(12):1067-73. PubMed ID: 8614296
[TBL] [Abstract][Full Text] [Related]
8. Modulation of 3-hydroxy-3-methylglutaryl-CoA reductase by 15 alpha-fluorolanost-7-en-3 beta-ol. A mechanism-based inhibitor of cholesterol biosynthesis.
Trzaskos JM; Magolda RL; Favata MF; Fischer RT; Johnson PR; Chen HW; Ko SS; Leonard DA; Gaylor JL
J Biol Chem; 1993 Oct; 268(30):22591-9. PubMed ID: 7693673
[TBL] [Abstract][Full Text] [Related]
9. Deformylation of 32-oxo-24,25-dihydrolanosterol by the purified cytochrome P-45014DM (lanosterol 14 alpha-demethylase) from yeast evidence confirming the intermediate step of lanosterol 14 alpha-demethylation.
Aoyama Y; Yoshida Y; Sonoda Y; Sato Y
J Biol Chem; 1989 Nov; 264(31):18502-5. PubMed ID: 2509459
[TBL] [Abstract][Full Text] [Related]
10. Metabolism of 32-hydroxy-24,25-dihydrolanosterol by purified cytochrome P-45014DM from yeast. Evidence for contribution of the cytochrome to whole process of lanosterol 14 alpha-demethylation.
Aoyama Y; Yoshida Y; Sonoda Y; Sato Y
J Biol Chem; 1987 Jan; 262(3):1239-43. PubMed ID: 3543000
[TBL] [Abstract][Full Text] [Related]
11. Selective inhibition of mammalian lanosterol 14 alpha-demethylase: a possible strategy for cholesterol lowering.
Walker KA; Kertesz DJ; Rotstein DM; Swinney DC; Berry PW; So OY; Webb AS; Watson DM; Mak AY; Burton PM
J Med Chem; 1993 Jul; 36(15):2235-7. PubMed ID: 8340925
[No Abstract] [Full Text] [Related]
12. 7-Oxo-24,25-dihydrolanosterol: a novel lanosterol 14 alpha-demethylase (P-45014DM) inhibitor which blocks electron transfer to the oxyferro intermediate.
Aoyama Y; Yoshida Y; Sonoda Y; Sato Y
Biochim Biophys Acta; 1987 Dec; 922(3):270-7. PubMed ID: 3318933
[TBL] [Abstract][Full Text] [Related]
13. Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase: II. Time-dependent enzyme inactivation by selected oxylanosterol analogs.
Trzaskos JM; Fischer RT; Ko SS; Magolda RL; Stam S; Johnson P; Gaylor JL
Biochemistry; 1995 Aug; 34(30):9677-81. PubMed ID: 7626637
[TBL] [Abstract][Full Text] [Related]
14. Cholesterol biosynthesis from lanosterol: differential inhibition of sterol delta 8-isomerase and other lanosterol-converting enzymes by tamoxifen.
Cho SY; Kim JH; Paik YK
Mol Cells; 1998 Apr; 8(2):233-9. PubMed ID: 9638657
[TBL] [Abstract][Full Text] [Related]
15. Role of meiosis-activating sterols in rat oocyte maturation: effects of specific inhibitors and changes in the expression of lanosterol 14alpha-demethylase during the preovulatory period.
Vaknin KM; Lazar S; Popliker M; Tsafriri A
Biol Reprod; 2001 Jan; 64(1):299-309. PubMed ID: 11133687
[TBL] [Abstract][Full Text] [Related]
16. Lanosterol 14 alpha-methyl demethylase. Isolation and characterization of the third metabolically generated oxidative demethylation intermediate.
Fischer RT; Trzaskos JM; Magolda RL; Ko SS; Brosz CS; Larsen B
J Biol Chem; 1991 Apr; 266(10):6124-32. PubMed ID: 2007571
[TBL] [Abstract][Full Text] [Related]
17. Substrate-based inhibitors of lanosterol 14 alpha-methyl demethylase: I. Assessment of inhibitor structure-activity relationship and cholesterol biosynthesis inhibition properties.
Trzaskos JM; Ko SS; Magolda RL; Favata MF; Fischer RT; Stam SH; Johnson PR; Gaylor JL
Biochemistry; 1995 Aug; 34(30):9670-6. PubMed ID: 7626636
[TBL] [Abstract][Full Text] [Related]
18. Selectivity of isoprenoid-containing imidazole antifungal compounds for sterol 14-demethylase P450 (P450(14)DM) and 7-ethoxycoumarin O-deethylase P450 of rat liver microsomes.
Ito T; Aoyama Y; Ishida K; Kudoh M; Hori K; Tsuchiya S; Yoshida Y
Biochem Pharmacol; 1994 Oct; 48(8):1577-82. PubMed ID: 7980623
[TBL] [Abstract][Full Text] [Related]
19. Biochemical basis for a cholesterol-lowering activity of 2-[2"-(1",3"-dioxolane)]-2-methyl-4-(2'-oxo-1'-pyrrolidinyl)-6- nitro-2H-1-benzopyran (SKP-450), a novel antihypertensive agent.
Lee EY; Lim DM; Yoo SE; Kim DK; Paik YK
Biochem Pharmacol; 1999 Mar; 57(5):579-82. PubMed ID: 9952322
[TBL] [Abstract][Full Text] [Related]
20. Microsomal enzymes of cholesterol biosynthesis. Purification of lanosterol 14 alpha-methyl demethylase cytochrome P-450 from hepatic microsomes.
Trzaskos J; Kawata S; Gaylor JL
J Biol Chem; 1986 Nov; 261(31):14651-7. PubMed ID: 3771545
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
