162 related articles for article (PubMed ID: 8178446)
1. The transmembrane domain of the large subunit of HSV-2 ribonucleotide reductase (ICP10) is required for protein kinase activity and transformation-related signaling pathways that result in ras activation.
Smith CC; Luo JH; Hunter JC; Ordonez JV; Aurelian L
Virology; 1994 May; 200(2):598-612. PubMed ID: 8178446
[TBL] [Abstract][Full Text] [Related]
2. Intracellular internalization and signaling pathways triggered by the large subunit of HSV-2 ribonucleotide reductase (ICP10).
Hunter JC; Smith CC; Bose D; Kulka M; Broderick R; Aurelian L
Virology; 1995 Jul; 210(2):345-60. PubMed ID: 7618272
[TBL] [Abstract][Full Text] [Related]
3. The protein kinase activity of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) fused to the extracellular domain of the epidermal growth factor receptor is ligand-inducible.
Smith CC; Luo JH; Aurelian L
Virology; 1996 Mar; 217(2):425-34. PubMed ID: 8610433
[TBL] [Abstract][Full Text] [Related]
4. The novel protein kinase of the RR1 subunit of herpes simplex virus has autophosphorylation and transphosphorylation activity that differs in its ATP requirements for HSV-1 and HSV-2.
Peng T; Hunter JR; Nelson JW
Virology; 1996 Feb; 216(1):184-96. PubMed ID: 8614985
[TBL] [Abstract][Full Text] [Related]
5. The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) blocks apoptosis in hippocampal neurons, involving activation of the MEK/MAPK survival pathway.
Perkins D; Pereira EF; Gober M; Yarowsky PJ; Aurelian L
J Virol; 2002 Feb; 76(3):1435-49. PubMed ID: 11773417
[TBL] [Abstract][Full Text] [Related]
6. A mutant type 2 herpes simplex virus deleted for the protein kinase domain of the ICP10 gene is a potent oncolytic virus.
Fu X; Tao L; Cai R; Prigge J; Zhang X
Mol Ther; 2006 May; 13(5):882-90. PubMed ID: 16569513
[TBL] [Abstract][Full Text] [Related]
7. The large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is associated with the virion tegument and has PK activity.
Smith CC; Aurelian L
Virology; 1997 Aug; 234(2):235-42. PubMed ID: 9268154
[TBL] [Abstract][Full Text] [Related]
8. Ras-GAP binding and phosphorylation by herpes simplex virus type 2 RR1 PK (ICP10) and activation of the Ras/MEK/MAPK mitogenic pathway are required for timely onset of virus growth.
Smith CC; Nelson J; Aurelian L; Gober M; Goswami BB
J Virol; 2000 Nov; 74(22):10417-29. PubMed ID: 11044086
[TBL] [Abstract][Full Text] [Related]
9. The transmembrane helical segment but not the invariant lysine is required for the kinase activity of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10).
Luo JH; Aurelian L
J Biol Chem; 1992 May; 267(14):9645-53. PubMed ID: 1315764
[TBL] [Abstract][Full Text] [Related]
10. The PK domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is required for immediate-early gene expression and virus growth.
Smith CC; Peng T; Kulka M; Aurelian L
J Virol; 1998 Nov; 72(11):9131-41. PubMed ID: 9765459
[TBL] [Abstract][Full Text] [Related]
11. Expression of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) is required for virus growth and neoplastic transformation.
Smith CC; Kulka M; Wymer JP; Chung TD; Aurelian L
J Gen Virol; 1992 Jun; 73 ( Pt 6)():1417-28. PubMed ID: 1318943
[TBL] [Abstract][Full Text] [Related]
12. Vaccine potential of a herpes simplex virus type 2 mutant deleted in the PK domain of the large subunit of ribonucleotide reductase (ICP10).
Aurelian L; Kokuba H; Smith CC
Vaccine; 1999 Apr; 17(15-16):1951-63. PubMed ID: 10217594
[TBL] [Abstract][Full Text] [Related]
13. The ribonucleotide reductase R1 subunits of herpes simplex virus types 1 and 2 protect cells against TNFα- and FasL-induced apoptosis by interacting with caspase-8.
Dufour F; Sasseville AM; Chabaud S; Massie B; Siegel RM; Langelier Y
Apoptosis; 2011 Mar; 16(3):256-71. PubMed ID: 21107701
[TBL] [Abstract][Full Text] [Related]
14. The 140-kDa RR1 protein from both HSV-1 and HSV-2 contains an intrinsic protein kinase activity capable of autophosphorylation but it is transphosphorylation defective.
Ali MA
Virology; 1995 Mar; 207(2):409-16. PubMed ID: 7886945
[TBL] [Abstract][Full Text] [Related]
15. Suppression of c-ras transformation by GTPase-activating protein.
Zhang K; DeClue JE; Vass WC; Papageorge AG; McCormick F; Lowy DR
Nature; 1990 Aug; 346(6286):754-6. PubMed ID: 2201922
[TBL] [Abstract][Full Text] [Related]
16. An HSV-2-based oncolytic virus deleted in the PK domain of the ICP10 gene is a potent inducer of apoptotic death in tumor cells.
Fu X; Tao L; Zhang X
Gene Ther; 2007 Aug; 14(16):1218-25. PubMed ID: 17538637
[TBL] [Abstract][Full Text] [Related]
17. Expression of herpes simplex virus type 2 protein ICP10 PK rescues neurons from apoptosis due to serum deprivation or genetic defects.
Perkins D; Yu Y; Bambrick LL; Yarowsky PJ; Aurelian L
Exp Neurol; 2002 Mar; 174(1):118-22. PubMed ID: 11869040
[TBL] [Abstract][Full Text] [Related]
18. AP-1 cis-response elements are involved in basal expression and Vmw110 transactivation of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10).
Zhu J; Aurelian L
Virology; 1997 May; 231(2):301-12. PubMed ID: 9168892
[TBL] [Abstract][Full Text] [Related]
19. Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth.
Murphy GA; Solski PA; Jillian SA; Pérez de la Ossa P; D'Eustachio P; Der CJ; Rush MG
Oncogene; 1999 Jul; 18(26):3831-45. PubMed ID: 10445846
[TBL] [Abstract][Full Text] [Related]
20. The hsv-2 la-1 oncoprotein is a member of a novel family of serine threonine receptor kinases.
Hunter J; Smith C; Aurelian L
Int J Oncol; 1995 Sep; 7(3):515-22. PubMed ID: 21552868
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]