96 related articles for article (PubMed ID: 8181462)
1. Ionization state and pKa of pterin-analogue ligands bound to dihydrofolate reductase.
Jeong SS; Gready JE
Eur J Biochem; 1994 May; 221(3):1055-62. PubMed ID: 8181462
[TBL] [Abstract][Full Text] [Related]
2. Structure-activity relationships and pH dependence of binding of 8-alkyl-N5-deazapterins to dihydrofolate reductase.
Ivery MT; Gready JE
J Med Chem; 1994 Nov; 37(24):4211-21. PubMed ID: 7990119
[TBL] [Abstract][Full Text] [Related]
3. Development of a spectrofluorimetric method for determining the pKa of pterin-analogue ligands bound to DHFR.
Jeong SS; Gready JE
Adv Exp Med Biol; 1993; 338():529-32. PubMed ID: 8304173
[No Abstract] [Full Text] [Related]
4. Human dihydrofolate reductase: reduction of alternative substrates, pH effects, and inhibition by deazafolates.
Williams EA; Morrison JF
Biochemistry; 1992 Jul; 31(29):6801-11. PubMed ID: 1637816
[TBL] [Abstract][Full Text] [Related]
5. The pH-dependence of the binding of dihydrofolate and substrate analogues to dihydrofolate reductase from Escherichia coli.
Stone SR; Morrison JF
Biochim Biophys Acta; 1983 Jun; 745(3):247-58. PubMed ID: 6344924
[TBL] [Abstract][Full Text] [Related]
6. Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate bound to dihydrofolate reductase: mechanistic implications.
Chen YQ; Kraut J; Blakley RL; Callender R
Biochemistry; 1994 Jun; 33(23):7021-6. PubMed ID: 8003467
[TBL] [Abstract][Full Text] [Related]
7. Computer-aided drug design: a free energy perturbation study on the binding of methyl-substituted pterins and N5-deazapterins to dihydrofolate reductase.
Cummins PL; Gready JE
J Comput Aided Mol Des; 1993 Oct; 7(5):535-55. PubMed ID: 8294945
[TBL] [Abstract][Full Text] [Related]
8. Energetically most likely substrate and active-site protonation sites and pathways in the catalytic mechanism of dihydrofolate reductase.
Cummins PL; Gready JE
J Am Chem Soc; 2001 Apr; 123(15):3418-28. PubMed ID: 11472112
[TBL] [Abstract][Full Text] [Related]
9. Novel mechanism-based substrates of dihydrofolate reductase and the thermodynamics of ligand binding: a comparison of theory and experiment for 8-methylpterin and 6,8-dimethylpterin.
Cummins PL; Gready JE
Proteins; 1993 Apr; 15(4):426-35. PubMed ID: 8460112
[TBL] [Abstract][Full Text] [Related]
10. Effect of enzyme and ligand protonation on the binding of folates to recombinant human dihydrofolate reductase: implications for the evolution of eukaryotic enzyme efficiency.
Appleman JR; Tsay JT; Freisheim JH; Blakley RL
Biochemistry; 1992 Apr; 31(14):3709-15. PubMed ID: 1314649
[TBL] [Abstract][Full Text] [Related]
11. The interaction of an ionizing ligand with enzymes having a single ionizing group. Implications for the reaction of folate analogues with dihydrofolate reductase.
Stone SR; Morrison JF
Biochim Biophys Acta; 1983 Jun; 745(3):237-46. PubMed ID: 6860674
[TBL] [Abstract][Full Text] [Related]
12. Catalytic mechanism of the dihydrofolate reductase reaction as determined by pH studies.
Stone SR; Morrison JF
Biochemistry; 1984 Jun; 23(12):2753-8. PubMed ID: 6380573
[TBL] [Abstract][Full Text] [Related]
13. QM/MM and SCRF studies of the ionization state of 8-methylpterin substrate bound to dihydrofolate reductase: existence of a low-barrier hydrogen bond.
Cummins PL; Gready JE
J Mol Graph Model; 2000 Feb; 18(1):42-9. PubMed ID: 10935206
[TBL] [Abstract][Full Text] [Related]
14. Affinity labeling of dihydrofolate reductase with an antifolate glyoxal.
Johanson RA; Henkin J
J Biol Chem; 1985 Feb; 260(3):1465-74. PubMed ID: 3881433
[TBL] [Abstract][Full Text] [Related]
15. 13C and 15N nuclear magnetic resonance evidence that the active site carboxyl group of dihydrofolate reductase is not involved in the relay of a proton to substrate.
Blakley RL; Appleman JR; Freisheim JH; Jablonsky MJ
Arch Biochem Biophys; 1993 Nov; 306(2):501-9. PubMed ID: 8105754
[TBL] [Abstract][Full Text] [Related]
16. Identification and energetic ranking of possible docking sites for pterin on dihydrofolate reductase.
Bliznyuk AA; Gready JE
J Comput Aided Mol Des; 1998 Jul; 12(4):325-33. PubMed ID: 9777491
[TBL] [Abstract][Full Text] [Related]
17. Calorimetric studies of ligand binding in R67 dihydrofolate reductase.
Jackson M; Chopra S; Smiley RD; Maynord PO; Rosowsky A; London RE; Levy L; Kalman TI; Howell EE
Biochemistry; 2005 Sep; 44(37):12420-33. PubMed ID: 16156655
[TBL] [Abstract][Full Text] [Related]
18. Mechanism of the reaction catalyzed by dihydrofolate reductase from Escherichia coli: pH and deuterium isotope effects with NADPH as the variable substrate.
Morrison JF; Stone SR
Biochemistry; 1988 Jul; 27(15):5499-506. PubMed ID: 3052578
[TBL] [Abstract][Full Text] [Related]
19. Consideration of the pH-dependent inhibition of dihydrofolate reductase by methotrexate.
Cannon WR; Garrison BJ; Benkovic SJ
J Mol Biol; 1997 Aug; 271(4):656-68. PubMed ID: 9281432
[TBL] [Abstract][Full Text] [Related]
20. Theoretical studies on the activation of the pterin cofactor in the catalytic mechanism of dihydrofolate reductase.
Gready JE
Biochemistry; 1985 Aug; 24(18):4761-6. PubMed ID: 4074659
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]