These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

135 related articles for article (PubMed ID: 8212737)

  • 1. Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituents.
    Koymans L; Donné-Op den Kelder GM; te Koppele JM; Vermeulen NP
    Xenobiotica; 1993 Jun; 23(6):633-48. PubMed ID: 8212737
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mechanisms of activation of phenacetin to reactive metabolites by cytochrome P-450: a theoretical study involving radical intermediates.
    Koymans L; Van Lenthe JH; Donné-op Den Kelder GM; Vermeulen NP
    Mol Pharmacol; 1990 Mar; 37(3):452-60. PubMed ID: 2314392
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450.
    Bessems JG; de Groot MJ; Baede EJ; te Koppele JM; Vermeulen NP
    Xenobiotica; 1998 Sep; 28(9):855-75. PubMed ID: 9764928
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A theoretical study on the metabolic activation of paracetamol by cytochrome P-450: indications for a uniform oxidation mechanism.
    Koymans L; van Lenthe JH; van de Straat R; Donné-Op den Kelder GM; Vermeulen NP
    Chem Res Toxicol; 1989; 2(1):60-6. PubMed ID: 2519233
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Metabolic activation and toxicity of acetaminophen and related analogs. A theoretical study.
    Loew GH; Goldblum A
    Mol Pharmacol; 1985 Mar; 27(3):375-86. PubMed ID: 2983185
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1- and 2-electron oxidation of paracetamol.
    van de Straat R; Vromans RM; Bosman P; de Vries J; Vermeulen NP
    Chem Biol Interact; 1988; 64(3):267-80. PubMed ID: 3342453
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Oxidations of p-alkoxyacylanilides catalyzed by human cytochrome P450 1A2: structure-activity relationships and simulation of rate constants of individual steps in catalysis.
    Yun CH; Miller GP; Guengerich FP
    Biochemistry; 2001 Apr; 40(14):4521-30. PubMed ID: 11284709
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Cytochrome P450-catalyzed oxidation of N-benzyl-N-cyclopropylamine generates both cyclopropanone hydrate and 3-hydroxypropionaldehyde via hydrogen abstraction, not single electron transfer.
    Cerny MA; Hanzlik RP
    J Am Chem Soc; 2006 Mar; 128(10):3346-54. PubMed ID: 16522116
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants.
    Yun CH; Miller GP; Guengerich FP
    Biochemistry; 2000 Sep; 39(37):11319-29. PubMed ID: 10985777
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Metabolite predictions for para-substituted anisoles based on ab initio complete active space self-consistent field calculations.
    de Groot MJ; Donné-Op den Kelder GM; Commandeur JN; van Lenthe JH; Vermeulen NP
    Chem Res Toxicol; 1995; 8(3):437-43. PubMed ID: 7578931
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Microsomal cytochrome P450 dependent oxidation of N-hydroxyguanidines, amidoximes, and ketoximes: mechanism of the oxidative cleavage of their C=N(OH) bond with formation of nitrogen oxides.
    Jousserandot A; Boucher JL; Henry Y; Niklaus B; Clement B; Mansuy D
    Biochemistry; 1998 Dec; 37(49):17179-91. PubMed ID: 9860831
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mechanism of cytochrome P450 2D6-catalyzed sparteine metabolism in humans.
    Ebner T; Meese CO; Eichelbaum M
    Mol Pharmacol; 1995 Dec; 48(6):1078-86. PubMed ID: 8848008
    [TBL] [Abstract][Full Text] [Related]  

  • 13. One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.
    Boerma JS; Vermeulen NP; Commandeur JN
    Chem Biol Interact; 2014 Jan; 207():32-40. PubMed ID: 24246759
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Direct electron spin resonance detection of free radical intermediates during the peroxidase catalyzed oxidation of phenacetin metabolites.
    Fischer V; Harman LS; West PR; Mason RP
    Chem Biol Interact; 1986 Nov; 60(2):115-27. PubMed ID: 3024853
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Hydrocarbon oxidation by Bis-mu-oxo manganese dimers: electron transfer, hydride transfer, and hydrogen atom transfer mechanisms.
    Larsen AS; Wang K; Lockwood MA; Rice GL; Won TJ; Lovell S; Sadílek M; Turecek F; Mayer JM
    J Am Chem Soc; 2002 Aug; 124(34):10112-23. PubMed ID: 12188675
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Comparative metabolic studies of phenacetin and structurally-related compounds in the rat.
    Smith GE; Griffiths LA
    Xenobiotica; 1976 Apr; 6(4):217-36. PubMed ID: 936643
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Computational biotransformation profile of paracetamol catalyzed by cytochrome P450.
    Ji L; Schüürmann G
    Chem Res Toxicol; 2015 Apr; 28(4):585-96. PubMed ID: 25548954
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Differential behavior of the sub-sites of cytochrome 450 active site in binding of substrates, and products (implications for coupling/uncoupling).
    Narasimhulu S
    Biochim Biophys Acta; 2007 Mar; 1770(3):360-75. PubMed ID: 17134838
    [TBL] [Abstract][Full Text] [Related]  

  • 19. A proton-shuttle mechanism mediated by the porphyrin in benzene hydroxylation by cytochrome p450 enzymes.
    de Visser SP; Shaik S
    J Am Chem Soc; 2003 Jun; 125(24):7413-24. PubMed ID: 12797816
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes.
    Jiang Y; He X; Ortiz de Montellano PR
    Biochemistry; 2006 Jan; 45(2):533-42. PubMed ID: 16401082
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.