BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

194 related articles for article (PubMed ID: 8221964)

  • 1. Dihydrodiol dehydrogenase and its role in polycyclic aromatic hydrocarbon metabolism.
    Penning TM
    Chem Biol Interact; 1993 Oct; 89(1):1-34. PubMed ID: 8221964
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The ubiquitous aldehyde reductase (AKR1A1) oxidizes proximate carcinogen trans-dihydrodiols to o-quinones: potential role in polycyclic aromatic hydrocarbon activation.
    Palackal NT; Burczynski ME; Harvey RG; Penning TM
    Biochemistry; 2001 Sep; 40(36):10901-10. PubMed ID: 11535067
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.
    Burczynski ME; Lin HK; Penning TM
    Cancer Res; 1999 Feb; 59(3):607-14. PubMed ID: 9973208
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Examination of diols and diol epoxides of polycyclic aromatic hydrocarbons as substrates for rat liver dihydrodiol dehydrogenase.
    Flowers-Geary L; Harvey RG; Penning TM
    Chem Res Toxicol; 1992; 5(4):576-83. PubMed ID: 1391625
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione.
    Burczynski ME; Harvey RG; Penning TM
    Biochemistry; 1998 May; 37(19):6781-90. PubMed ID: 9578563
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Spectroscopic identification of ortho-quinones as the products of polycyclic aromatic trans-dihydrodiol oxidation catalyzed by dihydrodiol dehydrogenase. A potential route of proximate carcinogen metabolism.
    Smithgall TE; Harvey RG; Penning TM
    J Biol Chem; 1988 Feb; 263(4):1814-20. PubMed ID: 3276678
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Specificity of human aldo-keto reductases, NAD(P)H:quinone oxidoreductase, and carbonyl reductases to redox-cycle polycyclic aromatic hydrocarbon diones and 4-hydroxyequilenin-o-quinone.
    Shultz CA; Quinn AM; Park JH; Harvey RG; Bolton JL; Maser E; Penning TM
    Chem Res Toxicol; 2011 Dec; 24(12):2153-66. PubMed ID: 21910479
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.
    Abedin Z; Sen S; Field J
    Chem Res Toxicol; 2012 Jan; 25(1):113-21. PubMed ID: 22053912
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Activation of polycyclic aromatic hydrocarbon trans-dihydrodiol proximate carcinogens by human aldo-keto reductase (AKR1C) enzymes and their functional overexpression in human lung carcinoma (A549) cells.
    Palackal NT; Lee SH; Harvey RG; Blair IA; Penning TM
    J Biol Chem; 2002 Jul; 277(27):24799-808. PubMed ID: 11978787
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Regiospecific reduction of polycyclic aromatic quinones by rabbit liver dihydrodiol dehydrogenases.
    Post K; Seidel A; Platt KL; Oesch F; Klein J
    Chem Biol Interact; 1994 Feb; 90(2):157-68. PubMed ID: 8156605
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Reactivity of benzo[a]pyrene-7,8-dione with DNA. Evidence for the formation of deoxyguanosine adducts.
    Shou M; Harvey RG; Penning TM
    Carcinogenesis; 1993 Mar; 14(3):475-82. PubMed ID: 8384091
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cytotoxicity of polycyclic aromatic hydrocarbon o-quinones in rat and human hepatoma cells.
    Flowers-Geary L; Harvey RG; Penning TM
    Chem Res Toxicol; 1993; 6(3):252-60. PubMed ID: 7686407
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Disposition and biological activity of benzo[a]pyrene-7,8-dione. A genotoxic metabolite generated by dihydrodiol dehydrogenase.
    Flowers L; Bleczinski WF; Burczynski ME; Harvey RG; Penning TM
    Biochemistry; 1996 Oct; 35(42):13664-72. PubMed ID: 8885846
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Stable expression of rat dihydrodiol dehydrogenase (AKR1C9) in human breast MCF-7 cells results in the formation of PAH-o-quinones and enzyme mediated cell death.
    Tsuruda L; Hou Yt ; Penning TM
    Chem Res Toxicol; 2001 Jul; 14(7):856-62. PubMed ID: 11453732
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Generation of reactive oxygen species during the enzymatic oxidation of polycyclic aromatic hydrocarbon trans-dihydrodiols catalyzed by dihydrodiol dehydrogenase.
    Penning TM; Ohnishi ST; Ohnishi T; Harvey RG
    Chem Res Toxicol; 1996; 9(1):84-92. PubMed ID: 8924621
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53.
    Yu D; Berlin JA; Penning TM; Field J
    Chem Res Toxicol; 2002 Jun; 15(6):832-42. PubMed ID: 12067251
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cytotoxicity and mutagenicity of polycyclic aromatic hydrocarbon ortho-quinones produced by dihydrodiol dehydrogenase.
    Flowers-Geary L; Bleczinki W; Harvey RG; Penning TM
    Chem Biol Interact; 1996 Jan; 99(1-3):55-72. PubMed ID: 8620579
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells.
    Park JH; Mangal D; Tacka KA; Quinn AM; Harvey RG; Blair IA; Penning TM
    Proc Natl Acad Sci U S A; 2008 May; 105(19):6846-51. PubMed ID: 18474869
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Non-K-region o-quinones as enzyme-generated inactivators of dihydrodiol dehydrogenase.
    Penning TM; Sharp RB; Smithgall TE
    Biochemistry; 1989 May; 28(10):4505-11. PubMed ID: 2669957
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor.
    Burczynski ME; Penning TM
    Cancer Res; 2000 Feb; 60(4):908-15. PubMed ID: 10706104
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.