BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

857 related articles for article (PubMed ID: 8228817)

  • 1. Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.
    Wiest DL; Yuan L; Jefferson J; Benveniste P; Tsokos M; Klausner RD; Glimcher LH; Samelson LE; Singer A
    J Exp Med; 1993 Nov; 178(5):1701-12. PubMed ID: 8228817
    [TBL] [Abstract][Full Text] [Related]  

  • 2. TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck.
    Wiest DL; Ashe JM; Abe R; Bolen JB; Singer A
    Immunity; 1996 May; 4(5):495-504. PubMed ID: 8630734
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes.
    Nakayama T; Wiest DL; Abraham KM; Munitz TI; Perlmutter RM; Singer A
    Proc Natl Acad Sci U S A; 1993 Nov; 90(22):10534-8. PubMed ID: 7902564
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes.
    Sohn SJ; Forbush KA; Pan XC; Perlmutter RM
    J Immunol; 2001 Feb; 166(4):2209-17. PubMed ID: 11160274
    [TBL] [Abstract][Full Text] [Related]  

  • 5. ZAP-70 protein promotes tyrosine phosphorylation of T cell receptor signaling motifs (ITAMs) in immature CD4(+)8(+) thymocytes with limiting p56(lck).
    Ashe JM; Wiest DL; Abe R; Singer A
    J Exp Med; 1999 Apr; 189(7):1163-8. PubMed ID: 10190908
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes.
    Kearse KP; Wiest DL; Singer A
    Proc Natl Acad Sci U S A; 1993 Mar; 90(6):2438-42. PubMed ID: 7681596
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.
    Nakayama T; Samelson LE; Nakayama Y; Munitz TI; Sheard M; June CH; Singer A
    Proc Natl Acad Sci U S A; 1991 Nov; 88(22):9949-53. PubMed ID: 1719558
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor.
    Norment AM; Forbush KA; Nguyen N; Malissen M; Perlmutter RM
    J Exp Med; 1997 Jan; 185(1):121-30. PubMed ID: 8996248
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Intrathymic signalling in immature CD4+CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain.
    Nakayama T; Singer A; Hsi ED; Samelson LE
    Nature; 1989 Oct; 341(6243):651-4. PubMed ID: 2477711
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.
    Stephen TL; Wilson BS; Laufer TM
    Proc Natl Acad Sci U S A; 2012 May; 109(19):7415-20. PubMed ID: 22529380
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Early molecular events induced by T cell receptor (TCR) signaling in immature CD4+ CD8+ thymocytes: increased synthesis of TCR-alpha protein is an early response to TCR signaling that compensates for TCR-alpha instability, improves TCR assembly, and parallels other indicators of positive selection.
    Kearse KP; Takahama Y; Punt JA; Sharrow SO; Singer A
    J Exp Med; 1995 Jan; 181(1):193-202. PubMed ID: 7528767
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The protein tyrosine kinase p56lck regulates TCR expression and T cell selection.
    Ericsson PO; Teh HS
    Int Immunol; 1995 Apr; 7(4):617-24. PubMed ID: 7547689
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Sequestration of CD4-associated Lck from the TCR complex may elicit T cell hyporesponsiveness in nonobese diabetic mice.
    Zhang J; Salojin K; Delovitch TL
    J Immunol; 1998 Feb; 160(3):1148-57. PubMed ID: 9570528
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cells.
    Benveniste P; Takahama Y; Wiest DL; Nakayama T; Sharrow SO; Singer A
    Proc Natl Acad Sci U S A; 1994 Jul; 91(15):6933-7. PubMed ID: 8041724
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The final maturation of at least some single-positive CD4(hi) thymocytes does not require T cell receptor-major histocompatibility complex contact.
    Dyall R; Nikolic-Zugić J
    J Exp Med; 1999 Sep; 190(6):757-64. PubMed ID: 10499914
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Self-specific MHC class II-restricted CD4-CD8- T cells that escape deletion and lack regulatory activity.
    Viret C; Janeway CA
    J Immunol; 2003 Jan; 170(1):201-9. PubMed ID: 12496401
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Entry of CD4-CD8- immature thymocytes into the CD4/CD8 developmental pathway is controlled by tyrosine kinase signals that can be provided through TCR components.
    Takahama Y; Hasegawa T; Itohara S; Ball EL; Sheard MA; Hashimoto Y
    Int Immunol; 1994 Oct; 6(10):1505-14. PubMed ID: 7826942
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Selective association between MHC class I-restricted T cell receptors, CDS, and activated tyrosine kinases on thymocytes undergoing positive selection.
    Carrera AC; Wee SB; Roberts TM; Pardoll DM
    J Immunol; 1992 Nov; 149(10):3142-9. PubMed ID: 1431093
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Delayed thymocyte development induced by augmented expression of p56lck.
    Abraham KM; Levin SD; Marth JD; Forbush KA; Perlmutter RM
    J Exp Med; 1991 Jun; 173(6):1421-32. PubMed ID: 1709675
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways.
    Veillette A; Zúñiga-Pflücker JC; Bolen JB; Kruisbeek AM
    J Exp Med; 1989 Nov; 170(5):1671-80. PubMed ID: 2478653
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 43.