191 related articles for article (PubMed ID: 8257154)
1. Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates.
Srinivas RV; Robbins BL; Connelly MC; Gong YF; Bischofberger N; Fridland A
Antimicrob Agents Chemother; 1993 Oct; 37(10):2247-50. PubMed ID: 8257154
[TBL] [Abstract][Full Text] [Related]
2. Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study.
Roux L; Priet S; Payrot N; Weck C; Fournier M; Zoulim F; Balzarini J; Canard B; Alvarez K
Eur J Med Chem; 2013 May; 63():869-81. PubMed ID: 23603046
[TBL] [Abstract][Full Text] [Related]
3. Antiretroviral activity and pharmacokinetics in mice of oral bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine, the bis(pivaloyloxymethyl) ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine.
Naesens L; Balzarini J; Bischofberger N; De Clercq E
Antimicrob Agents Chemother; 1996 Jan; 40(1):22-8. PubMed ID: 8787873
[TBL] [Abstract][Full Text] [Related]
4. Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
Hatse S; De Clercq E; Balzarini J
Mol Pharmacol; 1998 Nov; 54(5):907-17. PubMed ID: 9804626
[TBL] [Abstract][Full Text] [Related]
5. Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2).
Annaert P; Kinget R; Naesens L; de Clercq E; Augustijns P
Pharm Res; 1997 Apr; 14(4):492-6. PubMed ID: 9144737
[TBL] [Abstract][Full Text] [Related]
6. A human T lymphoid cell variant resistant to the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine shows a unique combination of a phosphorylation defect and increased efflux of the agent.
Robbins BL; Connelly MC; Marshall DR; Srinivas RV; Fridland A
Mol Pharmacol; 1995 Feb; 47(2):391-7. PubMed ID: 7870049
[TBL] [Abstract][Full Text] [Related]
7. Metabolic diversity and antiviral activities of acyclic nucleoside phosphonates.
Aduma P; Connelly MC; Srinivas RV; Fridland A
Mol Pharmacol; 1995 Apr; 47(4):816-22. PubMed ID: 7723743
[TBL] [Abstract][Full Text] [Related]
8. 5-Phosphoribosyl 1-pyrophosphate synthetase converts the acyclic nucleoside phosphonates 9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine directly to their antivirally active diphosphate derivatives.
Balzarini J; De Clercq E
J Biol Chem; 1991 May; 266(14):8686-9. PubMed ID: 1851154
[TBL] [Abstract][Full Text] [Related]
9. Susceptibilities of zidovudine-resistant variants of human immunodeficiency virus type 1 to inhibition by acyclic nucleoside phosphonates.
Gong YF; Marshall DR; Srinivas RV; Fridland A
Antimicrob Agents Chemother; 1994 Jul; 38(7):1683-7. PubMed ID: 7979311
[TBL] [Abstract][Full Text] [Related]
10. Pharmacokinetics and metabolism of selected prodrugs of PMEA in rats.
Shaw JP; Louie MS; Krishnamurthy VV; Arimilli MN; Jones RJ; Bidgood AM; Lee WA; Cundy KC
Drug Metab Dispos; 1997 Mar; 25(3):362-6. PubMed ID: 9172955
[TBL] [Abstract][Full Text] [Related]
11. Novel hepatotrophic prodrugs of the antiviral nucleoside 9-(2-phosphonylmethoxyethyl)adenine with improved pharmacokinetics and antiviral activity.
Biessen EA; Valentijn AR; De Vrueh RL; Van De Bilt E; Sliedregt LA; Prince P; Bijsterbosch MK; Van Boom JH; Van Der Marel GA; Abrahams PJ; Van Berkel TJ
FASEB J; 2000 Sep; 14(12):1784-92. PubMed ID: 10973928
[TBL] [Abstract][Full Text] [Related]
12. Activity of the (R)-enantiomers of 9-(2-phosphonylmethoxypropyl)-adenine and 9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine against human immunodeficiency virus in different human cell systems.
Balzarini J; Aquaro S; Perno CF; Witvrouw M; Holý A; De Clercq E
Biochem Biophys Res Commun; 1996 Feb; 219(2):337-41. PubMed ID: 8604988
[TBL] [Abstract][Full Text] [Related]
13. Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine.
Starrett JE; Tortolani DR; Hitchcock MJ; Martin JC; Mansuri MM
Antiviral Res; 1992 Sep; 19(3):267-73. PubMed ID: 1332606
[TBL] [Abstract][Full Text] [Related]
14. Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).
Zídek Z; Franková D; Holý A
Eur J Pharmacol; 1999 Jul; 376(1-2):91-100. PubMed ID: 10440094
[TBL] [Abstract][Full Text] [Related]
15. Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers.
Annaert P; Gosselin G; Pompon A; Benzaria S; Valette G; Imbach JL; Naesens L; Hatse S; de Clercq E; Van den Mooter G; Kinget R; Augustijns P
Pharm Res; 1998 Feb; 15(2):239-45. PubMed ID: 9523310
[TBL] [Abstract][Full Text] [Related]
16. Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.
Hartline CB; Gustin KM; Wan WB; Ciesla SL; Beadle JR; Hostetler KY; Kern ER
J Infect Dis; 2005 Feb; 191(3):396-9. PubMed ID: 15633099
[TBL] [Abstract][Full Text] [Related]
17. Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).
Starrett JE; Tortolani DR; Russell J; Hitchcock MJ; Whiterock V; Martin JC; Mansuri MM
J Med Chem; 1994 Jun; 37(12):1857-64. PubMed ID: 8021925
[TBL] [Abstract][Full Text] [Related]
18. Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.
Keith KA; Hitchcock MJ; Lee WA; Holý A; Kern ER
Antimicrob Agents Chemother; 2003 Jul; 47(7):2193-8. PubMed ID: 12821467
[TBL] [Abstract][Full Text] [Related]
19. Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.
Zídek Z; Kmonícková E; Holý A
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub; 2005 Dec; 149(2):315-9. PubMed ID: 16601779
[TBL] [Abstract][Full Text] [Related]
20. Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA.
Robbins BL; Srinivas RV; Kim C; Bischofberger N; Fridland A
Antimicrob Agents Chemother; 1998 Mar; 42(3):612-7. PubMed ID: 9517941
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
