BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

221 related articles for article (PubMed ID: 8262670)

  • 1. Unusually marked hypoxic sensitization to indoloquinone EO9 and mitomycin C in a human colon-tumour cell line that lacks DT-diaphorase activity.
    Plumb JA; Workman P
    Int J Cancer; 1994 Jan; 56(1):134-9. PubMed ID: 8262670
    [TBL] [Abstract][Full Text] [Related]  

  • 2. DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.
    Plumb JA; Gerritsen M; Workman P
    Br J Cancer; 1994 Dec; 70(6):1136-43. PubMed ID: 7526885
    [TBL] [Abstract][Full Text] [Related]  

  • 3. DT-diaphorase activity correlates with sensitivity to the indoloquinone EO9 in mouse and human colon carcinomas.
    Walton MI; Bibby MC; Double JA; Plumb JA; Workman P
    Eur J Cancer; 1992; 28A(10):1597-600. PubMed ID: 1389472
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Relative importance of DT-diaphorase and hypoxia in the bioactivation of EO9 by human lung tumor cell lines.
    Plumb JA; Gerritsen M; Milroy R; Thomson P; Workman P
    Int J Radiat Oncol Biol Phys; 1994 May; 29(2):295-9. PubMed ID: 8195022
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9.
    Fitzsimmons SA; Workman P; Grever M; Paull K; Camalier R; Lewis AD
    J Natl Cancer Inst; 1996 Mar; 88(5):259-69. PubMed ID: 8614004
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.
    Walton MI; Sugget N; Workman P
    Int J Radiat Oncol Biol Phys; 1992; 22(4):643-7. PubMed ID: 1544831
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Involvement of DT-diaphorase (EC 1.6.99.2) in the DNA cross-linking and sequence selectivity of the bioreductive anti-tumour agent EO9.
    Bailey SM; Wyatt MD; Friedlos F; Hartley JA; Knox RJ; Lewis AD; Workman P
    Br J Cancer; 1997; 76(12):1596-603. PubMed ID: 9413948
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The role of NAD(P)H: quinone reductase (EC 1.6.99.2, DT-diaphorase) in the reductive bioactivation of the novel indoloquinone antitumor agent EO9.
    Walton MI; Smith PJ; Workman P
    Cancer Commun; 1991 Jul; 3(7):199-206. PubMed ID: 1714284
    [TBL] [Abstract][Full Text] [Related]  

  • 9. EO9: relationship between DT-diaphorase levels and response in vitro and in vivo.
    Collard J; Matthew AM; Double JA; Bibby MC
    Br J Cancer; 1995 Jun; 71(6):1199-203. PubMed ID: 7779711
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Factors affecting sensitivity to EO9 in rodent and human tumour cells in vitro: DT-diaphorase activity and hypoxia.
    Robertson N; Haigh A; Adams GE; Stratford IJ
    Eur J Cancer; 1994; 30A(7):1013-9. PubMed ID: 7946565
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents.
    Doherty GP; Leith MK; Wang X; Curphey TJ; Begleiter A
    Br J Cancer; 1998 Apr; 77(8):1241-52. PubMed ID: 9579829
    [TBL] [Abstract][Full Text] [Related]  

  • 12. EO9: a novel bioreductive alkylating indoloquinone with preferential solid tumour activity and lack of bone marrow toxicity in preclinical models.
    Hendriks HR; Pizao PE; Berger DP; Kooistra KL; Bibby MC; Boven E; Dreef-van der Meulen HC; Henrar RE; Fiebig HH; Double JA
    Eur J Cancer; 1993; 29A(6):897-906. PubMed ID: 8484984
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Indoloquinone EO9: DNA interstrand cross-linking upon reduction by DT-diaphorase or xanthine oxidase.
    Maliepaard M; Wolfs A; Groot SE; de Mol NJ; Janssen LH
    Br J Cancer; 1995 Apr; 71(4):836-9. PubMed ID: 7536024
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
    Fourie J; Oleschuk CJ; Guziec F; Guziec L; Fiterman DJ; Monterrosa C; Begleiter A
    Cancer Chemother Pharmacol; 2002 Feb; 49(2):101-10. PubMed ID: 11862423
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9.
    Smitskamp-Wilms E; Hendriks HR; Peters GJ
    Gen Pharmacol; 1996 Apr; 27(3):421-9. PubMed ID: 8723519
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Reduction of the indoloquinone anticancer drug EO9 by purified DT-diaphorase: a detailed kinetic study and analysis of metabolites.
    Bailey SM; Lewis AD; Knox RJ; Patterson LH; Fisher GR; Workman P
    Biochem Pharmacol; 1998 Sep; 56(5):613-21. PubMed ID: 9783730
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structure-activity relationships for DT-diaphorase reduction of hypoxic cell directed agents: indoloquinones and diaziridinyl benzoquinones.
    Bailey SM; Suggett N; Walton MI; Workman P
    Int J Radiat Oncol Biol Phys; 1992; 22(4):649-53. PubMed ID: 1544832
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Chemosensitivity to the indoloquinone EO9 is correlated with DT-diaphorase activity and its gene expression.
    Smitskamp-Wilms E; Peters GJ; Pinedo HM; van Ark-Otte J; Giaccone G
    Biochem Pharmacol; 1994 Apr; 47(8):1325-32. PubMed ID: 7514407
    [TBL] [Abstract][Full Text] [Related]  

  • 19. DT-diaphorase activity in normal and neoplastic human tissues; an indicator for sensitivity to bioreductive agents?
    Smitskamp-Wilms E; Giaccone G; Pinedo HM; van der Laan BF; Peters GJ
    Br J Cancer; 1995 Oct; 72(4):917-21. PubMed ID: 7547240
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Establishment of an isogenic human colon tumor model for NQO1 gene expression: application to investigate the role of DT-diaphorase in bioreductive drug activation in vitro and in vivo.
    Sharp SY; Kelland LR; Valenti MR; Brunton LA; Hobbs S; Workman P
    Mol Pharmacol; 2000 Nov; 58(5):1146-55. PubMed ID: 11040064
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.