175 related articles for article (PubMed ID: 8293548)
1. Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s.
Styles JA; Davies A; Lim CK; De Matteis F; Stanley LA; White IN; Yuan ZX; Smith LL
Carcinogenesis; 1994 Jan; 15(1):5-9. PubMed ID: 8293548
[TBL] [Abstract][Full Text] [Related]
2. Clastogenic and aneugenic effects of tamoxifen and some of its analogues in hepatocytes from dosed rats and in human lymphoblastoid cells transfected with human P450 cDNAs (MCL-5 cells).
Styles JA; Davies A; Davies R; White IN; Smith LL
Carcinogenesis; 1997 Feb; 18(2):303-13. PubMed ID: 9054622
[TBL] [Abstract][Full Text] [Related]
3. An investigation into the activation and deactivation of chlorinated hydrocarbons to genotoxins in metabolically competent human cells.
Doherty AT; Ellard S; Parry EM; Parry JM
Mutagenesis; 1996 May; 11(3):247-74. PubMed ID: 8671747
[TBL] [Abstract][Full Text] [Related]
4. Micronucleus assays using cytochalasin-blocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P-450 and microsomal epoxide hydrolase.
Crofton-Sleigh C; Doherty A; Ellard S; Parry EM; Venitt S
Mutagenesis; 1993 Jul; 8(4):363-72. PubMed ID: 8377657
[TBL] [Abstract][Full Text] [Related]
5. Biotransformation of caffeine by cDNA-expressed human cytochromes P-450.
Ha HR; Chen J; Krahenbuhl S; Follath F
Eur J Clin Pharmacol; 1996; 49(4):309-15. PubMed ID: 8857078
[TBL] [Abstract][Full Text] [Related]
6. Metabolism of theophylline by cDNA-expressed human cytochromes P-450.
Ha HR; Chen J; Freiburghaus AU; Follath F
Br J Clin Pharmacol; 1995 Mar; 39(3):321-6. PubMed ID: 7619675
[TBL] [Abstract][Full Text] [Related]
7. Kinetic analysis of the activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone by heterologously expressed human P450 enzymes and the effect of P450-specific chemical inhibitors on this activation in human liver microsomes.
Patten CJ; Smith TJ; Murphy SE; Wang MH; Lee J; Tynes RE; Koch P; Yang CS
Arch Biochem Biophys; 1996 Sep; 333(1):127-38. PubMed ID: 8806763
[TBL] [Abstract][Full Text] [Related]
8. Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase.
Arlt VM; Stiborova M; Hewer A; Schmeiser HH; Phillips DH
Cancer Res; 2003 Jun; 63(11):2752-61. PubMed ID: 12782579
[TBL] [Abstract][Full Text] [Related]
9. In vitro micronucleus test in HepG2 transformants expressing a series of human cytochrome P450 isoforms with chemicals requiring metabolic activation.
Hashizume T; Yoshitomi S; Asahi S; Matsumura S; Chatani F; Oda H
Mutat Res; 2009; 677(1-2):1-7. PubMed ID: 19501186
[TBL] [Abstract][Full Text] [Related]
10. Alpha-hydroxylation of tamoxifen and toremifene by human and rat cytochrome P450 3A subfamily enzymes.
Kim SY; Suzuki N; Santosh Laxmi YR; Rieger R; Shibutani S
Chem Res Toxicol; 2003 Sep; 16(9):1138-44. PubMed ID: 12971802
[TBL] [Abstract][Full Text] [Related]
11. Comparative studies of MCL-5 cells and human lymphocytes for detecting indirect-acting clastogens.
Yamakage K; Kusakabe H; Tanaka N
Mutat Res; 1998 Jan; 412(1):55-61. PubMed ID: 9508364
[TBL] [Abstract][Full Text] [Related]
12. Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen.
Crewe HK; Notley LM; Wunsch RM; Lennard MS; Gillam EM
Drug Metab Dispos; 2002 Aug; 30(8):869-74. PubMed ID: 12124303
[TBL] [Abstract][Full Text] [Related]
13. Drug interaction potential of toremifene and N-desmethyltoremifene with multiple cytochrome P450 isoforms.
Kim J; Peraire C; SolĂ J; Johanning KM; Dalton JT; Veverka KA
Xenobiotica; 2011 Oct; 41(10):851-62. PubMed ID: 21726172
[TBL] [Abstract][Full Text] [Related]
14. A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6.
Crespi CL; Penman BW; Gelboin HV; Gonzalez FJ
Carcinogenesis; 1991 Jul; 12(7):1197-201. PubMed ID: 2070484
[TBL] [Abstract][Full Text] [Related]
15. Identification of the human liver microsomal cytochrome P450s involved in the metabolism of N-nitrosodi-n-propylamine.
Teiber JF; Hollenberg PF
Carcinogenesis; 2000 Aug; 21(8):1559-66. PubMed ID: 10910959
[TBL] [Abstract][Full Text] [Related]
16. Establishment of the transformants expressing human cytochrome P450 subtypes in HepG2, and their applications on drug metabolism and toxicology.
Yoshitomi S; Ikemoto K; Takahashi J; Miki H; Namba M; Asahi S
Toxicol In Vitro; 2001 Jun; 15(3):245-56. PubMed ID: 11377097
[TBL] [Abstract][Full Text] [Related]
17. Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes.
Patten CJ; Smith TJ; Friesen MJ; Tynes RE; Yang CS; Murphy SE
Carcinogenesis; 1997 Aug; 18(8):1623-30. PubMed ID: 9276639
[TBL] [Abstract][Full Text] [Related]
18. Comparative cytochrome P450 -1A1, -2A6, -2B6, -2C, -2D6, -2E1, -3A5 and -4B1 expressions in human larynx tissue analysed at mRNA level.
Sarikaya D; Bilgen C; Kamataki T; Topcu Z
Biopharm Drug Dispos; 2006 Nov; 27(8):353-9. PubMed ID: 16894644
[TBL] [Abstract][Full Text] [Related]
19. Biotransformation of tamoxifen in a human endometrial explant culture model.
Sharma M; Shubert DE; Sharma M; Lewis J; McGarrigle BP; Bofinger DP; Olson JR
Chem Biol Interact; 2003 Dec; 146(3):237-49. PubMed ID: 14642736
[TBL] [Abstract][Full Text] [Related]
20. Evidence for oxidative metabolism in the genotoxicity of the atmospheric reaction product 2-nitronaphthalene in human lymphoblastoid cell lines.
Sasaki JC; Arey J; Eastmond DA; Parks KK; Phousongphouang PT; Grosovsky AJ
Mutat Res; 1999 Sep; 445(1):113-25. PubMed ID: 10521697
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]