169 related articles for article (PubMed ID: 8294436)
1. Mode of binding of folate analogs to thymidylate synthase. Evidence for two asymmetric but interactive substrate binding sites.
Dev IK; Dallas WS; Ferone R; Hanlon M; McKee DD; Yates BB
J Biol Chem; 1994 Jan; 269(3):1873-82. PubMed ID: 8294436
[TBL] [Abstract][Full Text] [Related]
2. Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2'-deoxyuridylate and 10-propargyl-5,8-dideazafolate.
Matthews DA; Appelt K; Oatley SJ; Xuong NH
J Mol Biol; 1990 Aug; 214(4):923-36. PubMed ID: 2201778
[TBL] [Abstract][Full Text] [Related]
3. Entropy in bi-substrate enzymes: proposed role of an alternate site in chaperoning substrate into, and products out of, thymidylate synthase.
Birdsall DL; Finer-Moore J; Stroud RM
J Mol Biol; 1996 Jan; 255(3):522-35. PubMed ID: 8568895
[TBL] [Abstract][Full Text] [Related]
4. In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase.
Hanlon MH; Ferone R
Cancer Res; 1996 Jul; 56(14):3301-6. PubMed ID: 8764125
[TBL] [Abstract][Full Text] [Related]
5. The complex of the anti-cancer therapeutic, BW1843U89, with thymidylate synthase at 2.0 A resolution: implications for a new mode of inhibition.
Stout TJ; Stroud RM
Structure; 1996 Jan; 4(1):67-77. PubMed ID: 8805515
[TBL] [Abstract][Full Text] [Related]
6. Crystal structure of Escherichia coli thymidylate synthase with FdUMP and 10-propargyl-5,8-dideazafolate.
Matthews DA; Appelt K; Oatley SJ
Adv Enzyme Regul; 1989; 29():47-60. PubMed ID: 2699154
[TBL] [Abstract][Full Text] [Related]
7. Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft.
Radparvar S; Houghton PJ; Houghton JA
Biochem Pharmacol; 1989 Jan; 38(2):335-42. PubMed ID: 2914018
[TBL] [Abstract][Full Text] [Related]
8. Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase.
Duch DS; Banks S; Dev IK; Dickerson SH; Ferone R; Heath LS; Humphreys J; Knick V; Pendergast W; Singer S
Cancer Res; 1993 Feb; 53(4):810-8. PubMed ID: 8428362
[TBL] [Abstract][Full Text] [Related]
9. Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase.
Pogolotti AL; Danenberg PV; Santi DV
J Med Chem; 1986 Apr; 29(4):478-82. PubMed ID: 3754285
[TBL] [Abstract][Full Text] [Related]
10. Kinetic scheme for thymidylate synthase from Escherichia coli: determination from measurements of ligand binding, primary and secondary isotope effects, and pre-steady-state catalysis.
Spencer HT; Villafranca JE; Appleman JR
Biochemistry; 1997 Apr; 36(14):4212-22. PubMed ID: 9100016
[TBL] [Abstract][Full Text] [Related]
11. A stable binary complex between Leishmania major thymidylate synthase and the substrate deoxyuridylate. A slow-binding interaction.
Garvey EP; Santi DV
J Biol Chem; 1987 Jul; 262(19):9068-74. PubMed ID: 3597407
[TBL] [Abstract][Full Text] [Related]
12. Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis.
Galivan JH; Maley GF; Maley F
Biochemistry; 1976 Jan; 15(2):356-62. PubMed ID: 813762
[TBL] [Abstract][Full Text] [Related]
13. The role of cellular folates in the enhancement of activity of the thymidylate synthase inhibitor 10-propargyl-5,8-dideazafolate against hepatoma cells in vitro by inhibitors of dihydrofolate reductase.
Galivan J; Rhee MS; Johnson TB; Dilwith R; Nair MG; Bunni M; Priest DG
J Biol Chem; 1989 Jun; 264(18):10685-92. PubMed ID: 2525127
[TBL] [Abstract][Full Text] [Related]
14. Thymidylate synthetase and 2'-deoxyuridylate form a tight complex in the presence of pteroyltriglutamate.
Lockshin A; Danenberg PV
J Biol Chem; 1979 Dec; 254(24):12285-8. PubMed ID: 115883
[TBL] [Abstract][Full Text] [Related]
15. Binding of the anticancer drug ZD1694 to E. coli thymidylate synthase: assessing specificity and affinity.
Rutenber EE; Stroud RM
Structure; 1996 Nov; 4(11):1317-24. PubMed ID: 8939755
[TBL] [Abstract][Full Text] [Related]
16. The separate effects of E60Q in Lactobacillus casei thymidylate synthase delineate between mechanisms for formation of intermediates in catalysis.
Birdsall DL; Huang W; Santi DV; Stroud RM; Finer-Moore J
Protein Eng; 1998 Mar; 11(3):171-83. PubMed ID: 9613841
[TBL] [Abstract][Full Text] [Related]
17. Quinazoline folate analogs inhibit the catalytic activity of thymidylate synthase but allow binding of 5-fluorodeoxyuridylate.
Keyomarsi K; Moran RG
J Biol Chem; 1990 Nov; 265(31):19163-9. PubMed ID: 2146271
[TBL] [Abstract][Full Text] [Related]
18. Tight binding of folate substrates and inhibitors to recombinant mouse glycinamide ribonucleotide formyltransferase.
Sanghani SP; Moran RG
Biochemistry; 1997 Aug; 36(34):10506-16. PubMed ID: 9265631
[TBL] [Abstract][Full Text] [Related]
19. Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89.
Weichsel A; Montfort WR; Cieśla J; Maley F
Proc Natl Acad Sci U S A; 1995 Apr; 92(8):3493-7. PubMed ID: 7724588
[TBL] [Abstract][Full Text] [Related]
20. Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors.
Jansen G; Schornagel JH; Westerhof GR; Rijksen G; Newell DR; Jackman AL
Cancer Res; 1990 Dec; 50(23):7544-8. PubMed ID: 2253202
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
