154 related articles for article (PubMed ID: 8295215)
1. Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones.
Peterson EM; Xu K; Holland KD; McKeon AC; Rothman SM; Ferrendelli JA; Covey DF
J Med Chem; 1994 Jan; 37(2):275-86. PubMed ID: 8295215
[TBL] [Abstract][Full Text] [Related]
2. Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function.
Canney DJ; Lu HF; McKeon AC; Yoon KW; Xu K; Holland KD; Rothman SM; Ferrendelli JA; Covey DF
Bioorg Med Chem; 1998 Jan; 6(1):43-55. PubMed ID: 9502104
[TBL] [Abstract][Full Text] [Related]
3. Binding interactions of convulsant and anticonvulsant gamma-butyrolactones and gamma-thiobutyrolactones with the picrotoxin receptor.
Holland KD; McKeon AC; Covey DF; Ferrendelli JA
J Pharmacol Exp Ther; 1990 Aug; 254(2):578-83. PubMed ID: 2166797
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor.
Canney DJ; Holland KD; Levine JA; McKeon AC; Ferrendelli JA; Covey DF
J Med Chem; 1991 Apr; 34(4):1460-7. PubMed ID: 1849999
[TBL] [Abstract][Full Text] [Related]
5. Dual modulation of the gamma-aminobutyric acid type A receptor/ionophore by alkyl-substituted gamma-butyrolactones.
Holland KD; Mathews GC; Bolos-Sy AM; Tucker JB; Reddy PA; Covey DF; Ferrendelli JA; Rothman SM
Mol Pharmacol; 1995 Jun; 47(6):1217-23. PubMed ID: 7603463
[TBL] [Abstract][Full Text] [Related]
6. Contrasting actions of a convulsant barbiturate and its anticonvulsant enantiomer on the α1 β3 γ2L GABAA receptor account for their in vivo effects.
Desai R; Savechenkov PY; Zolkowska D; Ge RL; Rogawski MA; Bruzik KS; Forman SA; Raines DE; Miller KW
J Physiol; 2015 Nov; 593(22):4943-61. PubMed ID: 26378885
[TBL] [Abstract][Full Text] [Related]
7. Physiological comparison of alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone with benzodiazepine and barbiturate modulators of GABAA receptors.
Mathews GC; Bolos-Sy AM; Covey DF; Rothman SM; Ferrendelli JA
Neuropharmacology; 1996 Feb; 35(2):123-36. PubMed ID: 8734480
[TBL] [Abstract][Full Text] [Related]
8. Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
Levine JA; Ferrendelli JA; Covey DF
J Med Chem; 1986 Oct; 29(10):1996-9. PubMed ID: 3761317
[TBL] [Abstract][Full Text] [Related]
9. Common modes of action of gamma-butyrolactones and pentylenetetrazol on the GABAA receptor-ionophore complex.
Maksay G; Molnár P; Gruber L
Eur J Pharmacol; 1994 Dec; 288(1):61-8. PubMed ID: 7705469
[TBL] [Abstract][Full Text] [Related]
10. Enantioselectivity of alpha-benzyl-alpha-methyl-gamma-butyrolactone-mediated modulation of anticonvulsant activity and GABA(A) receptor function.
Gonzales EB; Bell-Horner CL; de la Cruz MA; Ferrendelli JA; Covey DF; Dillon GH
J Pharmacol Exp Ther; 2004 May; 309(2):677-83. PubMed ID: 14742738
[TBL] [Abstract][Full Text] [Related]
11. Convulsant and anticonvulsant cyclopentanones and cyclohexanones.
Holland KD; Naritoku DK; McKeon AC; Ferrendelli JA; Covey DF
Mol Pharmacol; 1990 Jan; 37(1):98-103. PubMed ID: 2153913
[TBL] [Abstract][Full Text] [Related]
12. Relative anticonvulsant effects of GABAmimetic and GABA modulatory agents.
Holland KD; McKeon AC; Canney DJ; Covey DF; Ferrendelli JA
Epilepsia; 1992; 33(6):981-6. PubMed ID: 1334454
[TBL] [Abstract][Full Text] [Related]
13. Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs.
Klunk WE; McKeon A; Covey DF; Ferrendelli JA
Science; 1982 Sep; 217(4564):1040-2. PubMed ID: 6810462
[TBL] [Abstract][Full Text] [Related]
14. Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones.
Gross RA; Covey DF; Ferrendelli JA
J Pharmacol Exp Ther; 1997 Feb; 280(2):686-94. PubMed ID: 9023280
[TBL] [Abstract][Full Text] [Related]
15. Physiological regulation of the picrotoxin receptor by gamma-butyrolactones and gamma-thiobutyrolactones in cultured hippocampal neurons.
Holland KD; Ferrendelli JA; Covey DF; Rothman SM
J Neurosci; 1990 Jun; 10(6):1719-27. PubMed ID: 2355246
[TBL] [Abstract][Full Text] [Related]
16. Effects of anticonvulsant and convulsant gamma-butyrolactones and thiobutyrolactones on GABA-mediated chloride uptake.
Naritoku DK; Levine JA; Covey DF; Ferrendelli JA
Biochem Pharmacol; 1987 Mar; 36(6):797-800. PubMed ID: 3566782
[No Abstract] [Full Text] [Related]
17. Effects of the anticonvulsant losigamone and its isomers on the GABAA receptor system.
Dimpfel W; Chatterjee SS; Nöldner M; Ticku MK
Epilepsia; 1995 Oct; 36(10):983-9. PubMed ID: 7555962
[TBL] [Abstract][Full Text] [Related]
18. Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons.
Holland KD; Canney DJ; Rothman SM; Ferrendelli JA; Covey DF
Brain Res; 1990 May; 516(1):147-50. PubMed ID: 2163720
[TBL] [Abstract][Full Text] [Related]
19. Anticonvulsant properties of alpha, gamma, and alpha, gamma-substituted gamma-butyrolactones.
Klunk WE; Covey DF; Ferrendelli JA
Mol Pharmacol; 1982 Sep; 22(2):438-43. PubMed ID: 7144736
[TBL] [Abstract][Full Text] [Related]
20. Gamma-butyrolactone antagonism of the picrotoxin receptor: comparison of a pure antagonist and a mixed antagonist/inverse agonist.
Holland KD; Yoon KW; Ferrendelli JA; Covey DF; Rothman SM
Mol Pharmacol; 1991 Jan; 39(1):79-84. PubMed ID: 1846222
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]