BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

174 related articles for article (PubMed ID: 8304189)

  • 1. The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.
    Kimbell R; Jackman AL; Boyle FT; Hardcastle A; Aherne W
    Adv Exp Med Biol; 1993; 338():597-600. PubMed ID: 8304189
    [No Abstract]   [Full Text] [Related]  

  • 2. Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583).
    Bavetsias V; Jackman AL; Thornton TJ; Pawelczak K; Boyle FT; Bisset GM
    Adv Exp Med Biol; 1993; 338():593-6. PubMed ID: 8304188
    [No Abstract]   [Full Text] [Related]  

  • 3. Substituted-2-desamino-2-methyl-quinazolinones. A series of novel antitumour agents.
    Boyle FT; Matusiak ZS; Hughes LR; Slater AM; Stephens TC; Smith MN; Brown M; Kimbell R; Jackman AL
    Adv Exp Med Biol; 1993; 338():585-8. PubMed ID: 8304185
    [No Abstract]   [Full Text] [Related]  

  • 4. Use of murine L5178Y lymphoma thymidine kinase mutants for in vitro and in vivo antitumour efficacy evaluation of novel thymidylate synthase inhibitors.
    Stephens TC; Smith MN; Waterman SE; McCloskey ML; Jackman AL; Boyle FT
    Adv Exp Med Biol; 1993; 338():589-92. PubMed ID: 8304186
    [No Abstract]   [Full Text] [Related]  

  • 5. Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
    Jackman AL; Kelland LR; Kimbell R; Brown M; Gibson W; Aherne GW; Hardcastle A; Boyle FT
    Br J Cancer; 1995 May; 71(5):914-24. PubMed ID: 7537518
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Gamma-linked dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8- dideazafolate as antitumour agents.
    Jackman AL; Bisset GM; Jodrell DI; Gibson W; Kimbell R; Bavetsias V; Calvert AH; Harrap KR; Stephens TC; Smith MN
    Adv Exp Med Biol; 1993; 338():579-84. PubMed ID: 8304184
    [TBL] [Abstract][Full Text] [Related]  

  • 7. ICI D1694, an inhibitor of thymidylate synthase for clinical study.
    Jackman AL; Jodrell DI; Gibson W; Stephens TC
    Adv Exp Med Biol; 1991; 309A():19-23. PubMed ID: 1789205
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.
    Jackman AL; Kimbell R; Brown M; Brunton L; Boyle FT
    Anticancer Drug Des; 1995 Oct; 10(7):555-72. PubMed ID: 7495479
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.
    Jackman AL; Marsham PR; Thornton TJ; Bishop JA; O'Connor BM; Hughes LR; Calvert AH; Jones TR
    J Med Chem; 1990 Nov; 33(11):3067-71. PubMed ID: 2231607
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Quinazoline analogues of folic acid as inhibitors of thymidylate synthetase from bacterial and mammalian sources.
    Scanlon KJ; Moroson BA; Bertino JR; Hynes JB
    Mol Pharmacol; 1979 Jul; 16(1):261-9. PubMed ID: 113660
    [No Abstract]   [Full Text] [Related]  

  • 11. Inhibition of thymidylate synthetase by the new quinazoline antifolate, CB 3717; enzyme purification and kinetics.
    Jackman AL; Calvert AH; Hart LI; Harrap KR
    Adv Exp Med Biol; 1984; 165 Pt B():375-8. PubMed ID: 6720434
    [No Abstract]   [Full Text] [Related]  

  • 12. Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.
    Curtin NJ; Bowman KJ; Turner RN; Huang B; Loughlin PJ; Calvert AH; Golding BT; Griffin RJ; Newell DR
    Br J Cancer; 1999 Aug; 80(11):1738-46. PubMed ID: 10468290
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Plasma nucleoside and base levels following treatment with the new thymidylate synthetase inhibitor CB 3717.
    Taylor GA; Jackman AL; Calvert AH; Harrap KR
    Adv Exp Med Biol; 1984; 165 Pt B():379-82. PubMed ID: 6720435
    [No Abstract]   [Full Text] [Related]  

  • 14. Immunoreactive dUMP and TTP pools as an index of thymidylate synthase inhibition; effect of tomudex (ZD1694) and a nonpolyglutamated quinazoline antifolate (CB30900) in L1210 mouse leukaemia cells.
    Aherne GW; Hardcastle A; Raynaud F; Jackman AL
    Biochem Pharmacol; 1996 May; 51(10):1293-301. PubMed ID: 8787544
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Estimation of the in vitro and in vivo inhibitory effects of antifolates upon thymidylate synthase (TS) in whole cells.
    Taylor GA; Jackman AL; Balmanno K; Hughes LR; Calvert AH
    Adv Exp Med Biol; 1989; 253B():383-8. PubMed ID: 2610126
    [No Abstract]   [Full Text] [Related]  

  • 16. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
    Jackman AL; Taylor GA; Gibson W; Kimbell R; Brown M; Calvert AH; Judson IR; Hughes LR
    Cancer Res; 1991 Oct; 51(20):5579-86. PubMed ID: 1913676
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.
    Hughes LR; Jackman AL; Oldfield J; Smith RC; Burrows KD; Marsham PR; Bishop JA; Jones TR; O'Connor BM; Calvert AH
    J Med Chem; 1990 Nov; 33(11):3060-7. PubMed ID: 2231606
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A potent antitumour quinazoline inhibitor of thymidylate synthetase: synthesis, biological properties and therapeutic results in mice.
    Jones TR; Calvert AH; Jackman AL; Brown SJ; Jones M; Harrap KR
    Eur J Cancer (1965); 1981 Jan; 17(1):11-9. PubMed ID: 7262141
    [No Abstract]   [Full Text] [Related]  

  • 19. Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
    Bavetsias V; Jackman AL; Kimbell R; Gibson W; Boyle FT; Bisset GM
    J Med Chem; 1996 Jan; 39(1):73-85. PubMed ID: 8568829
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Biochemical and antitumor effects of 5,8-dideazaisopteroylglutamate, a unique quinazoline inhibitor of thymidylate synthase.
    Fernandes DJ; Bertino JR; Hynes JB
    Cancer Res; 1983 Mar; 43(3):1117-23. PubMed ID: 6825083
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 9.