These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

130 related articles for article (PubMed ID: 8359989)

  • 21. Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.
    Rosowsky A; Papoulis AT; Forsch RA; Queener SF
    J Med Chem; 1999 Mar; 42(6):1007-17. PubMed ID: 10090784
    [TBL] [Abstract][Full Text] [Related]  

  • 22. N10-propargyl-5,8-dideazafolic acid (CB3717): inhibitory effects on human leukemia cell lines resistant to methotrexate or trimetrexate.
    Takemura Y; Ohnuma T
    Mt Sinai J Med; 1992 Oct; 59(5):419-24. PubMed ID: 1435841
    [TBL] [Abstract][Full Text] [Related]  

  • 23. In vitro screening of biochemical activity of folic acid antagonists in skin.
    McCullough JL; Weinstein GD; Hynes JB
    J Invest Dermatol; 1977 Jun; 68(6):362-5. PubMed ID: 864277
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
    Rhee MS; Galivan J; Wright JE; Rosowsky A
    Mol Pharmacol; 1994 Apr; 45(4):783-91. PubMed ID: 7514264
    [TBL] [Abstract][Full Text] [Related]  

  • 25. A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells.
    Sharma RC; Assaraf YG; Schimke RT
    Cancer Res; 1991 Jun; 51(11):2949-59. PubMed ID: 1674447
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Inhibition of Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium dihydrofolate reductases by 2,4-diamino-5-[2-methoxy-5-(omega-carboxyalkyloxy)benzyl]pyrimidines: marked improvement in potency relative to trimethoprim and species selectivity relative to piritrexim.
    Rosowsky A; Forsch RA; Queener SF
    J Med Chem; 2002 Jan; 45(1):233-41. PubMed ID: 11754594
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Quantitation of folic acid enhancement of antifolate synergism.
    Gaumont Y; Kisliuk RL; Parsons JC; Greco WR
    Cancer Res; 1992 Apr; 52(8):2228-35. PubMed ID: 1532766
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Evaluation of potent inhibitors of dihydrofolate reductase in a culture model for growth of Pneumocystis carinii.
    Bartlett MS; Shaw M; Navaran P; Smith JW; Queener SF
    Antimicrob Agents Chemother; 1995 Nov; 39(11):2436-41. PubMed ID: 8585722
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Multiple mechanisms of resistance to polyglutamatable and lipophilic antifolates in mammalian cells: role of increased folylpolyglutamylation, expanded folate pools, and intralysosomal drug sequestration.
    Jansen G; Barr H; Kathmann I; Bunni MA; Priest DG; Noordhuis P; Peters GJ; Assaraf YG
    Mol Pharmacol; 1999 Apr; 55(4):761-9. PubMed ID: 10101035
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Potent effect of trimetrexate, a lipid-soluble antifolate, on Toxoplasma gondii.
    Kovacs JA; Allegra CJ; Chabner BA; Swan JC; Drake J; Lunde M; Parrillo JE; Masur H
    J Infect Dis; 1987 May; 155(5):1027-32. PubMed ID: 2951446
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines.
    Sirawaraporn W; Sertsrivanich R; Booth RG; Hansch C; Neal RA; Santi DV
    Mol Biochem Parasitol; 1988 Oct; 31(1):79-85. PubMed ID: 3185614
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Evidence for a localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells.
    Matherly LH; Muench SP
    Biochem Pharmacol; 1990 Jun; 39(12):2005-14. PubMed ID: 2141258
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folate repletion, confer drug resistance to CHL cells.
    Zhu WY; Bunni M; Priest DG; DiCapua JL; Dressler JM; Chen Z; Melera PW
    J Exp Ther Oncol; 2002; 2(5):264-77. PubMed ID: 12416030
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimethoprim and pyrimethamine.
    Zimmerman J; Selhub J; Rosenberg IH
    Am J Clin Nutr; 1987 Sep; 46(3):518-22. PubMed ID: 3630970
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Role of substrate depletion in the inhibition of thymidylate biosynthesis by the dihydrofolate reductase inhibitor trimetrexate in cultured hepatoma cells.
    Rhee MS; Balinska M; Bunni M; Priest DG; Maley GF; Maley F; Galivan J
    Cancer Res; 1990 Jul; 50(13):3979-84. PubMed ID: 2162250
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines.
    Chan JH; Hong JS; Kuyper LF; Baccanari DP; Joyner SS; Tansik RL; Boytos CM; Rudolph SK
    J Med Chem; 1995 Sep; 38(18):3608-16. PubMed ID: 7658448
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Super in vitro synergy between inhibitors of dihydrofolate reductase and inhibitors of other folate-requiring enzymes: the critical role of polyglutamylation.
    Faessel HM; Slocum HK; Jackson RC; Boritzki TJ; Rustum YM; Nair MG; Greco WR
    Cancer Res; 1998 Jul; 58(14):3036-50. PubMed ID: 9679969
    [TBL] [Abstract][Full Text] [Related]  

  • 38. The characteristics and consequences of folate depletion in hepatoma cells in vitro by inhibition of dihydrofolate reductase.
    Galivan J; Nimec Z; Rotundo R
    Adv Enzyme Regul; 1989; 29():209-17. PubMed ID: 2633609
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate synthase by fluorodeoxyuridine in L1210 leukemia cells.
    Seither RL; Rape TJ; Goldman ID
    Biochem Pharmacol; 1992 Jun; 43(12):2647-54. PubMed ID: 1385949
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets.
    Assaraf YG; Ifergan I; Kadry WN; Pinter RY
    J Theor Biol; 2006 Jun; 240(4):637-47. PubMed ID: 16352313
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 7.