These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

179 related articles for article (PubMed ID: 8367461)

  • 1. Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A.
    Maryanoff BE; Qiu X; Padmanabhan KP; Tulinsky A; Almond HR; Andrade-Gordon P; Greco MN; Kauffman JA; Nicolaou KC; Liu A
    Proc Natl Acad Sci U S A; 1993 Sep; 90(17):8048-52. PubMed ID: 8367461
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin.
    Ganesh V; Lee AY; Clardy J; Tulinsky A
    Protein Sci; 1996 May; 5(5):825-35. PubMed ID: 8732754
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Cyclotheonamide derivatives: synthesis and thrombin inhibition. Exploration of specific structure-function issues.
    Maryanoff BE; Zhang HC; Greco MN; Glover KA; Kauffman JA; Andrade-Gordon P
    Bioorg Med Chem; 1995 Aug; 3(8):1025-38. PubMed ID: 7582977
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibition of thrombin and other trypsin-like serine proteinases by cyclotheonamide A.
    Lewis SD; Ng AS; Baldwin JJ; Fusetani N; Naylor AM; Shafer JA
    Thromb Res; 1993 Apr; 70(2):173-90. PubMed ID: 8322286
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
    Costanzo MJ; Almond HR; Hecker LR; Schott MR; Yabut SC; Zhang HC; Andrade-Gordon P; Corcoran TW; Giardino EC; Kauffman JA; Lewis JM; de Garavilla L; Haertlein BJ; Maryanoff BE
    J Med Chem; 2005 Mar; 48(6):1984-2008. PubMed ID: 15771442
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.
    Katz BA; Elrod K; Luong C; Rice MJ; Mackman RL; Sprengeler PA; Spencer J; Hataye J; Janc J; Link J; Litvak J; Rai R; Rice K; Sideris S; Verner E; Young W
    J Mol Biol; 2001 Apr; 307(5):1451-86. PubMed ID: 11292354
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis, structure, and structure-activity relationships of divalent thrombin inhibitors containing an alpha-keto-amide transition-state mimetic.
    Krishnan R; Tulinsky A; Vlasuk GP; Pearson D; Vallar P; Bergum P; Brunck TK; Ripka WC
    Protein Sci; 1996 Mar; 5(3):422-33. PubMed ID: 8868478
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Profiling the structural determinants for the selectivity of representative factor-Xa and thrombin inhibitors using combined ligand-based and structure-based approaches.
    Bhunia SS; Roy KK; Saxena AK
    J Chem Inf Model; 2011 Aug; 51(8):1966-85. PubMed ID: 21761917
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Crystallographic structure of a peptidyl keto acid inhibitor and human alpha-thrombin.
    Håkansson K; Tulinsky A; Abelman MM; Miller TA; Vlasuk GP; Bergum PW; Lim-Wilby MS; Brunck TK
    Bioorg Med Chem; 1995 Aug; 3(8):1009-17. PubMed ID: 7582975
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The methyl group of N(alpha)(Me)Arg-containing peptides disturbs the active-site geometry of thrombin, impairing efficient cleavage.
    Friedrich R; Steinmetzer T; Huber R; Stürzebecher J; Bode W
    J Mol Biol; 2002 Mar; 316(4):869-74. PubMed ID: 11884127
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin.
    Baum B; Muley L; Heine A; Smolinski M; Hangauer D; Klebe G
    J Mol Biol; 2009 Aug; 391(3):552-64. PubMed ID: 19520086
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
    Malikayil JA; Burkhart JP; Schreuder HA; Broersma RJ; Tardif C; Kutcher LW; Mehdi S; Schatzman GL; Neises B; Peet NP
    Biochemistry; 1997 Feb; 36(5):1034-40. PubMed ID: 9033393
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif.
    Chen X; Riley BT; de Veer SJ; Hoke DE; Van Haeften J; Leahy D; Swedberg JE; Brattsand M; Hartfield PJ; Buckle AM; Harris JM
    PLoS One; 2019; 14(1):e0210842. PubMed ID: 30668585
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cyclotheonamides E2 and E3, new potent serine protease inhibitors from the marine sponge of the genus Theonella.
    Nakao Y; Oku N; Matsunaga S; Fusetani N
    J Nat Prod; 1998 May; 61(5):667-70. PubMed ID: 9599274
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.
    Katz BA; Elrod K; Verner E; Mackman RL; Luong C; Shrader WD; Sendzik M; Spencer JR; Sprengeler PA; Kolesnikov A; Tai VW; Hui HC; Breitenbucher JG; Allen D; Janc JW
    J Mol Biol; 2003 May; 329(1):93-120. PubMed ID: 12742021
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural features of a snake venom thrombin-like enzyme: thrombin and trypsin on a single catalytic platform?
    Castro HC; Silva DM; Craik C; Zingali RB
    Biochim Biophys Acta; 2001 Jun; 1547(2):183-95. PubMed ID: 11410274
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
    Féthière J; Tsuda Y; Coulombe R; Konishi Y; Cygler M
    Protein Sci; 1996 Jun; 5(6):1174-83. PubMed ID: 8762149
    [TBL] [Abstract][Full Text] [Related]  

  • 18. The crystal structures of human alpha-thrombin complexed with active site-directed diamino benzo[b]thiophene derivatives: a binding mode for a structurally novel class of inhibitors.
    Chirgadze NY; Sall DJ; Briggs SL; Clawson DK; Zhang M; Smith GF; Schevitz RW
    Protein Sci; 2000 Jan; 9(1):29-36. PubMed ID: 10739244
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090.
    Malley MF; Tabernero L; Chang CY; Ohringer SL; Roberts DG; Das J; Sack JS
    Protein Sci; 1996 Feb; 5(2):221-8. PubMed ID: 8745399
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
    Zdanov A; Wu S; DiMaio J; Konishi Y; Li Y; Wu X; Edwards BF; Martin PD; Cygler M
    Proteins; 1993 Nov; 17(3):252-65. PubMed ID: 8272424
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.