These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

516 related articles for article (PubMed ID: 8395332)

  • 1. Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin.
    Hayes JD; Judah DJ; Neal GE
    Cancer Res; 1993 Sep; 53(17):3887-94. PubMed ID: 8395332
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases.
    Kensler TW; Egner PA; Davidson NE; Roebuck BD; Pikul A; Groopman JD
    Cancer Res; 1986 Aug; 46(8):3924-31. PubMed ID: 2873884
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Regulation of glutathione S-transferases and aldehyde reductase by chemoprotectors: studies of mechanisms responsible for inducible resistance to aflatoxin B1.
    Hayes JD; McLeod R; Ellis EM; Pulford DJ; Ireland LS; McLellan LI; Judah DJ; Manson MM; Neal GE
    IARC Sci Publ; 1996; (139):175-87. PubMed ID: 8923030
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Metabolic basis for the protective effect of the antioxidant ethoxyquin on aflatoxin B1 hepatocarcinogenesis in the rat.
    Mandel HG; Manson MM; Judah DJ; Simpson JL; Green JA; Forrester LM; Wolf CR; Neal GE
    Cancer Res; 1987 Oct; 47(19):5218-23. PubMed ID: 2887284
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin.
    McLeod R; Ellis EM; Arthur JR; Neal GE; Judah DJ; Manson MM; Hayes JD
    Cancer Res; 1997 Oct; 57(19):4257-66. PubMed ID: 9331086
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors.
    McLellan LI; Judah DJ; Neal GE; Hayes JD
    Biochem J; 1994 May; 300 ( Pt 1)(Pt 1):117-24. PubMed ID: 8198522
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Ethoxyquin-induced resistance to aflatoxin B1 in the rat is associated with the expression of a novel alpha-class glutathione S-transferase subunit, Yc2, which possesses high catalytic activity for aflatoxin B1-8,9-epoxide.
    Hayes JD; Judah DJ; McLellan LI; Kerr LA; Peacock SD; Neal GE
    Biochem J; 1991 Oct; 279 ( Pt 2)(Pt 2):385-98. PubMed ID: 1953636
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Comparative activities of glutathione-S-transferase and dialdehyde reductase toward aflatoxin B1 in livers of experimental and farm animals.
    Tulayakul P; Sakuda S; Dong KS; Kumagai S
    Toxicon; 2005 Aug; 46(2):204-9. PubMed ID: 15964045
    [TBL] [Abstract][Full Text] [Related]  

  • 9. An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases.
    Ellis EM; Judah DJ; Neal GE; Hayes JD
    Proc Natl Acad Sci U S A; 1993 Nov; 90(21):10350-4. PubMed ID: 8234296
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver.
    Kelly VP; Ellis EM; Manson MM; Chanas SA; Moffat GJ; McLeod R; Judah DJ; Neal GE; Hayes JD
    Cancer Res; 2000 Feb; 60(4):957-69. PubMed ID: 10706111
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Indole-3-carbinol induces a rat liver glutathione transferase subunit (Yc2) with high activity toward aflatoxin B1 exo-epoxide. Association with reduced levels of hepatic aflatoxin-DNA adducts in vivo.
    Stresser DM; Williams DE; McLellan LI; Harris TM; Bailey GS
    Drug Metab Dispos; 1994; 22(3):392-9. PubMed ID: 8070315
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Protection against aflatoxin B1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): predictive role for short-term molecular dosimetry.
    Roebuck BD; Liu YL; Rogers AE; Groopman JD; Kensler TW
    Cancer Res; 1991 Oct; 51(20):5501-6. PubMed ID: 1680553
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Purification from rat liver of a novel constitutively expressed member of the aldo-keto reductase 7 family that is widely distributed in extrahepatic tissues.
    Kelly VP; Ireland LS; Ellis EM; Hayes JD
    Biochem J; 2000 Jun; 348 Pt 2(Pt 2):389-400. PubMed ID: 10816434
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones.
    Kensler TW; Egner PA; Dolan PM; Groopman JD; Roebuck BD
    Cancer Res; 1987 Aug; 47(16):4271-7. PubMed ID: 2886217
    [TBL] [Abstract][Full Text] [Related]  

  • 15. cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3.
    Knight LP; Primiano T; Groopman JD; Kensler TW; Sutter TR
    Carcinogenesis; 1999 Jul; 20(7):1215-23. PubMed ID: 10383892
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1.
    Hayes JD; Pulford DJ; Ellis EM; McLeod R; James RF; Seidegård J; Mosialou E; Jernström B; Neal GE
    Chem Biol Interact; 1998 Apr; 111-112():51-67. PubMed ID: 9679543
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Temporal patterns of DNA adduct formation and glutathione S-transferase activity in the testes of rats fed aflatoxin B1: a comparison with patterns in the liver.
    Sotomayor RE; Sahu S; Washington M; Hinton DM; Chou M
    Environ Mol Mutagen; 1999; 33(4):293-302. PubMed ID: 10398377
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Low hepatic glutathione S-transferase and increased hepatic DNA adduction contribute to increased tumorigenicity of aflatoxin B1 in newborn and partially hepatectomized mice.
    Shupe T; Sell S
    Toxicol Lett; 2004 Mar; 148(1-2):1-9. PubMed ID: 15019083
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz.
    Roebuck BD; Curphey TJ; Li Y; Baumgartner KJ; Bodreddigari S; Yan J; Gange SJ; Kensler TW; Sutter TR
    Carcinogenesis; 2003 Dec; 24(12):1919-28. PubMed ID: 14555609
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant.
    Judah DJ; Hayes JD; Yang JC; Lian LY; Roberts GC; Farmer PB; Lamb JH; Neal GE
    Biochem J; 1993 May; 292 ( Pt 1)(Pt 1):13-8. PubMed ID: 8503840
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 26.