132 related articles for article (PubMed ID: 8415574)
1. The structure of a designed peptidomimetic inhibitor complex of alpha-thrombin.
Wu TP; Yee V; Tulinsky A; Chrusciel RA; Nakanishi H; Shen R; Priebe C; Kahn M
Protein Eng; 1993 Jul; 6(5):471-8. PubMed ID: 8415574
[TBL] [Abstract][Full Text] [Related]
2. The isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: changes accompanying activation and exosite binding to thrombin.
Vijayalakshmi J; Padmanabhan KP; Mann KG; Tulinsky A
Protein Sci; 1994 Dec; 3(12):2254-71. PubMed ID: 7756983
[TBL] [Abstract][Full Text] [Related]
3. Structure of the Ser195Ala mutant of human alpha--thrombin complexed with fibrinopeptide A(7--16): evidence for residual catalytic activity.
Krishnan R; Sadler JE; Tulinsky A
Acta Crystallogr D Biol Crystallogr; 2000 Apr; 56(Pt 4):406-10. PubMed ID: 10739913
[TBL] [Abstract][Full Text] [Related]
4. The structure of residues 7-16 of the A alpha-chain of human fibrinogen bound to bovine thrombin at 2.3-A resolution.
Martin PD; Robertson W; Turk D; Huber R; Bode W; Edwards BF
J Biol Chem; 1992 Apr; 267(11):7911-20. PubMed ID: 1560020
[TBL] [Abstract][Full Text] [Related]
5. Structure of the hirugen and hirulog 1 complexes of alpha-thrombin.
Skrzypczak-Jankun E; Carperos VE; Ravichandran KG; Tulinsky A; Westbrook M; Maraganore JM
J Mol Biol; 1991 Oct; 221(4):1379-93. PubMed ID: 1942057
[TBL] [Abstract][Full Text] [Related]
6. Comparison of the structures of the cyclotheonamide A complexes of human alpha-thrombin and bovine beta-trypsin.
Ganesh V; Lee AY; Clardy J; Tulinsky A
Protein Sci; 1996 May; 5(5):825-35. PubMed ID: 8732754
[TBL] [Abstract][Full Text] [Related]
7. Structures of thrombin retro-inhibited with SEL2711 and SEL2770 as they relate to factor Xa binding.
Mochalkin I; Tulinsky A
Acta Crystallogr D Biol Crystallogr; 1999 Apr; 55(Pt 4):785-93. PubMed ID: 10089309
[TBL] [Abstract][Full Text] [Related]
8. Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.
Qiu X; Padmanabhan KP; Carperos VE; Tulinsky A; Kline T; Maraganore JM; Fenton JW
Biochemistry; 1992 Dec; 31(47):11689-97. PubMed ID: 1445905
[TBL] [Abstract][Full Text] [Related]
9. The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.
Bode W; Turk D; Karshikov A
Protein Sci; 1992 Apr; 1(4):426-71. PubMed ID: 1304349
[TBL] [Abstract][Full Text] [Related]
10. Crystal structure of human alpha-thrombin complexed with hirugen and p-amidinophenylpyruvate at 1.6 A resolution.
Chen Z; Li Y; Mulichak AM; Lewis SD; Shafer JA
Arch Biochem Biophys; 1995 Sep; 322(1):198-203. PubMed ID: 7574675
[TBL] [Abstract][Full Text] [Related]
11. Bovine thrombin complexed with an uncleavable analog of residues 7-19 of fibrinogen A alpha: geometry of the catalytic triad and interactions of the P1', P2', and P3' substrate residues.
Martin PD; Malkowski MG; DiMaio J; Konishi Y; Ni F; Edwards BF
Biochemistry; 1996 Oct; 35(40):13030-9. PubMed ID: 8855938
[TBL] [Abstract][Full Text] [Related]
12. Crystal structure of the complex of human alpha-thrombin and nonhydrolyzable bifunctional inhibitors, hirutonin-2 and hirutonin-6.
Zdanov A; Wu S; DiMaio J; Konishi Y; Li Y; Wu X; Edwards BF; Martin PD; Cygler M
Proteins; 1993 Nov; 17(3):252-65. PubMed ID: 8272424
[TBL] [Abstract][Full Text] [Related]
13. Molecular design and characterization of an alpha-thrombin inhibitor containing a novel P1 moiety.
Malikayil JA; Burkhart JP; Schreuder HA; Broersma RJ; Tardif C; Kutcher LW; Mehdi S; Schatzman GL; Neises B; Peet NP
Biochemistry; 1997 Feb; 36(5):1034-40. PubMed ID: 9033393
[TBL] [Abstract][Full Text] [Related]
14. Human alpha-thrombin inhibition by the active site titrant N alpha-(N,N-dimethylcarbamoyl)-alpha-azalysine p-nitrophenyl ester: a comparative kinetic and X-ray crystallographic study.
Nardini M; Pesce A; Rizzi M; Casale E; Ferraccioli R; Balliano G; Milla P; Ascenzi P; Bolognesi M
J Mol Biol; 1996 May; 258(5):851-9. PubMed ID: 8637015
[TBL] [Abstract][Full Text] [Related]
15. Structure of a retro-binding peptide inhibitor complexed with human alpha-thrombin.
Tabernero L; Chang CY; Ohringer SL; Lau WF; Iwanowicz EJ; Han WC; Wang TC; Seiler SM; Roberts DG; Sack JS
J Mol Biol; 1995 Feb; 246(1):14-20. PubMed ID: 7853394
[TBL] [Abstract][Full Text] [Related]
16. The influence of direct and antithrombin-dependent thrombin inhibitors on the procoagulant and anticoagulant effects of thrombin.
Linder R; Frebelius S; Grip L; Swedenborg J
Thromb Res; 2003 Jun; 110(4):221-6. PubMed ID: 14512086
[TBL] [Abstract][Full Text] [Related]
17. Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human alpha-thrombin.
Féthière J; Tsuda Y; Coulombe R; Konishi Y; Cygler M
Protein Sci; 1996 Jun; 5(6):1174-83. PubMed ID: 8762149
[TBL] [Abstract][Full Text] [Related]
18. Thrombin-bound structures of designed analogs of human fibrinopeptide A determined by quantitative transferred NOE spectroscopy: a new structural basis for thrombin specificity.
Ni F; Zhu Y; Scheraga HA
J Mol Biol; 1995 Oct; 252(5):656-71. PubMed ID: 7563081
[TBL] [Abstract][Full Text] [Related]
19. In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design.
Costanzo MJ; Almond HR; Hecker LR; Schott MR; Yabut SC; Zhang HC; Andrade-Gordon P; Corcoran TW; Giardino EC; Kauffman JA; Lewis JM; de Garavilla L; Haertlein BJ; Maryanoff BE
J Med Chem; 2005 Mar; 48(6):1984-2008. PubMed ID: 15771442
[TBL] [Abstract][Full Text] [Related]
20. Changes in interactions in complexes of hirudin derivatives and human alpha-thrombin due to different crystal forms.
Priestle JP; Rahuel J; Rink H; Tones M; Grütter MG
Protein Sci; 1993 Oct; 2(10):1630-42. PubMed ID: 8251938
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
