These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

134 related articles for article (PubMed ID: 8419350)

  • 1. Engineering mouse P450coh to a novel corticosterone 15 alpha-hydroxylase and modeling steroid-binding orientation in the substrate pocket.
    Iwasaki M; Darden TA; Pedersen LG; Davis DG; Juvonen RO; Sueyoshi T; Negishi M
    J Biol Chem; 1993 Jan; 268(2):759-62. PubMed ID: 8419350
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.
    Iwasaki M; Lindberg RL; Juvonen RO; Negishi M
    Biochem J; 1993 Apr; 291 ( Pt 2)(Pt 2):569-73. PubMed ID: 8484736
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Altering the regiospecificity of androstenedione hydroxylase activity in P450s 2a-4/5 by a mutation of the residue at position 481.
    Iwasaki M; Darden TA; Pedersen LG; Negishi M
    Biochemistry; 1995 Apr; 34(15):5054-9. PubMed ID: 7711025
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Multiple steroid-binding orientations: alteration of regiospecificity of dehydroepiandrosterone 2- and 7-hydroxylase activities of cytochrome P-450 2a-5 by mutation of residue 209.
    Iwasaki M; Davis DG; Darden TA; Pedersen LG; Negishi M
    Biochem J; 1995 Feb; 306 ( Pt 1)(Pt 1):29-33. PubMed ID: 7864823
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.
    Negishi M; Iwasaki M; Juvonen RO; Aida K
    J Steroid Biochem Mol Biol; 1992 Dec; 43(8):1031-6. PubMed ID: 22217847
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inherent versatility of P-450 oxygenase. Conferring dehydroepiandrosterone hydroxylase activity to P-450 2a-4 by a single amino acid mutation at position 117.
    Iwasaki M; Darden TA; Parker CE; Tomer KB; Pedersen LG; Negishi M
    J Biol Chem; 1994 Mar; 269(12):9079-83. PubMed ID: 8132645
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Alterations of the regiospecificity of progesterone metabolism by the mutagenesis of two key amino acid residues in rabbit cytochrome P450 2C3v.
    Richardson TH; Johnson EF
    J Biol Chem; 1994 Sep; 269(39):23937-43. PubMed ID: 7929041
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural function of residue-209 in coumarin 7-hydroxylase (P450coh). Enzyme-kinetic studies and site-directed mutagenesis.
    Juvonen RO; Iwasaki M; Negishi M
    J Biol Chem; 1991 Sep; 266(25):16431-5. PubMed ID: 1885576
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
    Luo Z; He YA; Halpert JR
    Arch Biochem Biophys; 1994 Feb; 309(1):52-7. PubMed ID: 8117113
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Hydrophobic side chain requirements for lauric acid and progesterone hydroxylation at amino acid 113 in cytochrome P450 2C2, a potential determinant of substrate specificity.
    Straub P; Johnson EF; Kemper B
    Arch Biochem Biophys; 1993 Nov; 306(2):521-7. PubMed ID: 8215458
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Engineering of cytochrome P450 2B1 specificity. Conversion of an androgen 16 beta-hydroxylase to a 15 alpha-hydroxylase.
    Halpert JR; He YA
    J Biol Chem; 1993 Feb; 268(6):4453-7. PubMed ID: 8440727
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.
    Lewis DF; Lake BG
    Xenobiotica; 2002 Jul; 32(7):547-61. PubMed ID: 12162851
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.
    Lang MA; Juvonen R; Järvinen P; Honkakoski P; Raunio H
    Arch Biochem Biophys; 1989 May; 271(1):139-48. PubMed ID: 2712571
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.
    Lindberg RL; Juvonen R; Negishi M
    Pharmacogenetics; 1992 Feb; 2(1):32-7. PubMed ID: 1302041
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
    Smith G; Modi S; Pillai I; Lian LY; Sutcliffe MJ; Pritchard MP; Friedberg T; Roberts GC; Wolf CR
    Biochem J; 1998 May; 331 ( Pt 3)(Pt 3):783-92. PubMed ID: 9560305
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Roles of residues 129 and 209 in the alteration by cytochrome b5 of hydroxylase activities in mouse 2A P450S.
    Juvonen RO; Iwasaki M; Negishi M
    Biochemistry; 1992 Nov; 31(46):11519-23. PubMed ID: 1445886
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Elucidation of amino acid residues critical for unique activities of rabbit cytochrome P450 2B5 using hybrid enzymes and reciprocal site-directed mutagenesis with rabbit cytochrome P450 2B4.
    Szklarz GD; He YQ; Kedzie KM; Halpert JR; Burnett VL
    Arch Biochem Biophys; 1996 Mar; 327(2):308-18. PubMed ID: 8619620
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A single amino acid substitution confers progesterone 6 beta-hydroxylase activity to rabbit cytochrome P450 2C3.
    Hsu MH; Griffin KJ; Wang Y; Kemper B; Johnson EF
    J Biol Chem; 1993 Apr; 268(10):6939-44. PubMed ID: 8463225
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.
    Lindberg RL; Negishi M
    Nature; 1989 Jun; 339(6226):632-4. PubMed ID: 2733794
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Role of residue 480 in substrate specificity of cytochrome P450 2B5 and 2B11.
    Liu J; He YA; Halpert JR
    Arch Biochem Biophys; 1996 Mar; 327(1):167-73. PubMed ID: 8615687
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.