BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

251 related articles for article (PubMed ID: 8419946)

  • 1. Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.
    Bergstrom JD; Kurtz MM; Rew DJ; Amend AM; Karkas JD; Bostedor RG; Bansal VS; Dufresne C; VanMiddlesworth FL; Hensens OD
    Proc Natl Acad Sci U S A; 1993 Jan; 90(1):80-4. PubMed ID: 8419946
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase.
    Dufresne C; Wilson KE; Singh SB; Zink DL; Bergstrom JD; Rew D; Polishook JD; Meinz M; Huang L; Silverman KC
    J Nat Prod; 1993 Nov; 56(11):1923-9. PubMed ID: 8289063
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase.
    Bergstrom JD; Dufresne C; Bills GF; Nallin-Omstead M; Byrne K
    Annu Rev Microbiol; 1995; 49():607-39. PubMed ID: 8561474
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Massive production of farnesol-derived dicarboxylic acids in mice treated with the squalene synthase inhibitor zaragozic acid A.
    Vaidya S; Bostedor R; Kurtz MM; Bergstrom JD; Bansal VS
    Arch Biochem Biophys; 1998 Jul; 355(1):84-92. PubMed ID: 9647670
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Effect of squalene synthase inhibition on the expression of hepatic cholesterol biosynthetic enzymes, LDL receptor, and cholesterol 7 alpha hydroxylase.
    Ness GC; Zhao Z; Keller RK
    Arch Biochem Biophys; 1994 Jun; 311(2):277-85. PubMed ID: 7911291
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The preparation of zaragozic acid A analogues by directed biosynthesis.
    Chen TS; Petuch B; MacConnell J; White R; Dezeny G; Arison B; Bergstrom JD; Colwell L; Huang L; Monaghan RL
    J Antibiot (Tokyo); 1994 Nov; 47(11):1290-4. PubMed ID: 8002393
    [TBL] [Abstract][Full Text] [Related]  

  • 7. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. V. Minor metabolites.
    Blows WM; Foster G; Lane SJ; Noble D; Piercey JE; Sidebottom PJ; Webb G
    J Antibiot (Tokyo); 1994 Jul; 47(7):740-54. PubMed ID: 8071119
    [TBL] [Abstract][Full Text] [Related]  

  • 8. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. II. Structure elucidation.
    Sidebottom PJ; Highcock RM; Lane SJ; Procopiou PA; Watson NS
    J Antibiot (Tokyo); 1992 May; 45(5):648-58. PubMed ID: 1624367
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. IV. Preparation of fluorinated squalestatins by directed biosynthesis.
    Cannell RJ; Dawson MJ; Hale RS; Hall RM; Noble D; Lynn S; Taylor NL
    J Antibiot (Tokyo); 1993 Sep; 46(9):1381-9. PubMed ID: 8226317
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The squalestatins, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.
    Dawson MJ; Farthing JE; Marshall PS; Middleton RF; O'Neill MJ; Shuttleworth A; Stylli C; Tait RM; Taylor PM; Wildman HG
    J Antibiot (Tokyo); 1992 May; 45(5):639-47. PubMed ID: 1624366
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Competitive inhibition of squalene synthetase by squalestatin 1.
    Hasumi K; Tachikawa K; Sakai K; Murakawa S; Yoshikawa N; Kumazawa S; Endo A
    J Antibiot (Tokyo); 1993 Apr; 46(4):689-91. PubMed ID: 8501015
    [No Abstract]   [Full Text] [Related]  

  • 12. Biological activities of novel zaragozic acids, the potent inhibitors of squalene synthase, produced by the fungus, Mollisia sp. SANK 10294.
    Tanimoto T; Hamano K; Onodera K; Hosoya T; Kakusaka M; Hirayama T; Shimada Y; Koga T; Tsujita Y
    J Antibiot (Tokyo); 1997 May; 50(5):390-4. PubMed ID: 9207908
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Inhibitory activity to protein prenylation and antifungal activity of zaragozic acid D3, a potent inhibitor of squalene synthase produced by the fungus, Mollisia sp. SANK 10294.
    Tanimoto T; Ohya S; Tsujita Y
    J Antibiot (Tokyo); 1998 Apr; 51(4):428-31. PubMed ID: 9630865
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Selective protection and relative importance of the carboxylic acid groups of zaragozic acid A for squalene synthase inhibition.
    Biftu T; Acton JJ; Berger GD; Bergstrom JD; Dufresne C; Kurtz MM; Marquis RW; Parsons WH; Rew DR; Wilson KE
    J Med Chem; 1994 Feb; 37(3):421-4. PubMed ID: 8308869
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Farnesol-derived dicarboxylic acids in the urine of animals treated with zaragozic acid A or with farnesol.
    Bostedor RG; Karkas JD; Arison BH; Bansal VS; Vaidya S; Germershausen JI; Kurtz MM; Bergstrom JD
    J Biol Chem; 1997 Apr; 272(14):9197-203. PubMed ID: 9083051
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
    Ponpipom MM; Girotra NN; Bugianesi RL; Roberts CD; Berger GD; Burk RM; Marquis RW; Parsons WH; Bartizal KF; Bergstom JD
    J Med Chem; 1994 Nov; 37(23):4031-51. PubMed ID: 7966163
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Squalestatin 1, a potent inhibitor of squalene synthase, which lowers serum cholesterol in vivo.
    Baxter A; Fitzgerald BJ; Hutson JL; McCarthy AD; Motteram JM; Ross BC; Sapra M; Snowden MA; Watson NS; Williams RJ
    J Biol Chem; 1992 Jun; 267(17):11705-8. PubMed ID: 1601846
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Production of additional squalestatin analogues by directed biosynthesis.
    Cannell RJ; Dawson MJ; Hale RS; Hall RM; Noble D; Lynn S; Taylor NL
    J Antibiot (Tokyo); 1994 Feb; 47(2):247-9. PubMed ID: 8150722
    [No Abstract]   [Full Text] [Related]  

  • 19. Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis.
    Kojro E; Füger P; Prinzen C; Kanarek AM; Rat D; Endres K; Fahrenholz F; Postina R
    J Alzheimers Dis; 2010; 20(4):1215-31. PubMed ID: 20413873
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Inhibition of squalene synthase but not squalene cyclase prevents mevalonate-mediated suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at a posttranscriptional level.
    Peffley DM; Gayen AK
    Arch Biochem Biophys; 1997 Jan; 337(2):251-60. PubMed ID: 9016820
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.