These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

387 related articles for article (PubMed ID: 8424795)

  • 1. Site-directed mutation studies of human liver cytochrome P-450 isoenzymes in the CYP2C subfamily.
    Veronese ME; Doecke CJ; Mackenzie PI; McManus ME; Miners JO; Rees DL; Gasser R; Meyer UA; Birkett DJ
    Biochem J; 1993 Jan; 289 ( Pt 2)(Pt 2):533-8. PubMed ID: 8424795
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Oxidation of tienilic acid by human yeast-expressed cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this drug is a mechanism-based inhibitor specific for cytochrome P-450 2C9.
    Jean P; Lopez-Garcia P; Dansette P; Mansuy D; Goldstein JL
    Eur J Biochem; 1996 Nov; 241(3):797-804. PubMed ID: 8944768
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9.
    Veronese ME; Mackenzie PI; Doecke CJ; McManus ME; Miners JO; Birkett DJ
    Biochem Biophys Res Commun; 1991 Mar; 175(3):1112-8. PubMed ID: 2025243
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes.
    Srivastava PK; Yun CH; Beaune PH; Ged C; Guengerich FP
    Mol Pharmacol; 1991 Jul; 40(1):69-79. PubMed ID: 1857342
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of human cytochrome P450 isoforms involved in the metabolism of S-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid.
    Taguchi K; Konishi T; Nishikawa H; Kitamura S
    Xenobiotica; 1999 Sep; 29(9):899-907. PubMed ID: 10548450
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Roles of two allelic variants (Arg144Cys and Ile359Leu) of cytochrome P4502C9 in the oxidation of tolbutamide and warfarin by human liver microsomes.
    Yamazaki H; Inoue K; Shimada T
    Xenobiotica; 1998 Feb; 28(2):103-15. PubMed ID: 9522436
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine.
    Giancarlo GM; Venkatakrishnan K; Granda BW; von Moltke LL; Greenblatt DJ
    Eur J Clin Pharmacol; 2001 Apr; 57(1):31-6. PubMed ID: 11372587
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Relationship between phenytoin and tolbutamide hydroxylations in human liver microsomes.
    Doecke CJ; Veronese ME; Pond SM; Miners JO; Birkett DJ; Sansom LN; McManus ME
    Br J Clin Pharmacol; 1991 Feb; 31(2):125-30. PubMed ID: 2049228
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Human hepatic cytochrome P450 2C9 catalyzes the rate-limiting pathway of torsemide metabolism.
    Miners JO; Rees DL; Valente L; Veronese ME; Birkett DJ
    J Pharmacol Exp Ther; 1995 Mar; 272(3):1076-81. PubMed ID: 7891318
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Characterization of CYP2C19 and CYP2C9 from human liver: respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylations.
    Lasker JM; Wester MR; Aramsombatdee E; Raucy JL
    Arch Biochem Biophys; 1998 May; 353(1):16-28. PubMed ID: 9578596
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs.
    Mancy A; Antignac M; Minoletti C; Dijols S; Mouries V; Duong NT; Battioni P; Dansette PM; Mansuy D
    Biochemistry; 1999 Oct; 38(43):14264-70. PubMed ID: 10572000
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.
    Goldstein JA; Faletto MB; Romkes-Sparks M; Sullivan T; Kitareewan S; Raucy JL; Lasker JM; Ghanayem BI
    Biochemistry; 1994 Feb; 33(7):1743-52. PubMed ID: 8110777
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonamides on hepatic cytochrome P4502C activity in vitro, and correlation with some molecular descriptors in the dwarf goat (Caprus hircus aegagrus).
    Zweers-Zeilmaker WM; Horbach GJ; Witkamp RF
    Xenobiotica; 1997 Aug; 27(8):769-80. PubMed ID: 9293615
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Relationship between CYP2C9 and 2C19 genotypes and tolbutamide methyl hydroxylation and S-mephenytoin 4'-hydroxylation activities in livers of Japanese and Caucasian populations.
    Inoue K; Yamazaki H; Imiya K; Akasaka S; Guengerich FP; Shimada T
    Pharmacogenetics; 1997 Apr; 7(2):103-13. PubMed ID: 9170147
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Relative quantities of catalytically active CYP 2C9 and 2C19 in human liver microsomes: application of the relative activity factor approach.
    Venkatakrishnan K; von Moltke LL; Greenblatt DJ
    J Pharm Sci; 1998 Jul; 87(7):845-53. PubMed ID: 9649353
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Studies of flurbiprofen 4'-hydroxylation. Additional evidence suggesting the sole involvement of cytochrome P450 2C9.
    Tracy TS; Marra C; Wrighton SA; Gonzalez FJ; Korzekwa KR
    Biochem Pharmacol; 1996 Oct; 52(8):1305-9. PubMed ID: 8937439
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Major role of human liver microsomal cytochrome P450 2C9 (CYP2C9) in the oxidative metabolism of celecoxib, a novel cyclooxygenase-II inhibitor.
    Tang C; Shou M; Mei Q; Rushmore TH; Rodrigues AD
    J Pharmacol Exp Ther; 2000 May; 293(2):453-9. PubMed ID: 10773015
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes.
    Wester MR; Lasker JM; Johnson EF; Raucy JL
    Drug Metab Dispos; 2000 Mar; 28(3):354-9. PubMed ID: 10681382
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Comparison of the substrate specificities of human liver cytochrome P450s 2C9 and 2C18: application to the design of a specific substrate of CYP 2C18.
    Minoletti C; Dijols S; Dansette PM; Mansuy D
    Biochemistry; 1999 Jun; 38(24):7828-36. PubMed ID: 10387023
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver.
    Leemann T; Transon C; Dayer P
    Life Sci; 1993; 52(1):29-34. PubMed ID: 8417277
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 20.