151 related articles for article (PubMed ID: 8431360)
1. Metabolism of the bioreductive cytotoxin SR 4233 by tumour cells: enzymatic studies.
Wang J; Biedermann KA; Wolf CR; Brown JM
Br J Cancer; 1993 Feb; 67(2):321-5. PubMed ID: 8431360
[TBL] [Abstract][Full Text] [Related]
2. Initial characterization of the major mouse cytochrome P450 enzymes involved in the reductive metabolism of the hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, SR 4233, WIN 59075).
Riley RJ; Hemingway SA; Graham MA; Workman P
Biochem Pharmacol; 1993 Mar; 45(5):1065-77. PubMed ID: 8461036
[TBL] [Abstract][Full Text] [Related]
3. Enzymology of the reductive bioactivation of SR 4233. A novel benzotriazine di-N-oxide hypoxic cell cytotoxin.
Walton MI; Workman P
Biochem Pharmacol; 1990 Jun; 39(11):1735-42. PubMed ID: 2344370
[TBL] [Abstract][Full Text] [Related]
4. The role of cytochrome P450 and cytochrome P450 reductase in the reductive bioactivation of the novel benzotriazine di-N-oxide hypoxic cytotoxin 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233, WIN 59075) by mouse liver.
Walton MI; Wolf CR; Workman P
Biochem Pharmacol; 1992 Jul; 44(2):251-9. PubMed ID: 1642640
[TBL] [Abstract][Full Text] [Related]
5. Reduction of 3-amino-1,2,4-benzotriazine-1,4-di-N-oxide (tirapazamine, WIN 59075, SR 4233) to a DNA-damaging species: a direct role for NADPH:cytochrome P450 oxidoreductase.
Fitzsimmons SA; Lewis AD; Riley RJ; Workman P
Carcinogenesis; 1994 Aug; 15(8):1503-10. PubMed ID: 8055626
[TBL] [Abstract][Full Text] [Related]
6. Enzymology of the reduction of the potent benzotriazine-di-N-oxide hypoxic cell cytotoxin SR 4233 (WIN 59075) by NAD(P)H: (quinone acceptor) oxidoreductase (EC 1.6.99.2) purified from Walker 256 rat tumour cells.
Riley RJ; Workman P
Biochem Pharmacol; 1992 Jan; 43(2):167-74. PubMed ID: 1739405
[TBL] [Abstract][Full Text] [Related]
7. Pharmacokinetics and bioreductive metabolism of the novel benzotriazine di-N-oxide hypoxic cell cytotoxin tirapazamine (WIN 59075; SR 4233; NSC 130181) in mice.
Walton MI; Workman P
J Pharmacol Exp Ther; 1993 May; 265(2):938-47. PubMed ID: 8496834
[TBL] [Abstract][Full Text] [Related]
8. Metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) by purified DT-diaphorase under aerobic and anaerobic conditions.
Cahill A; Jenkins TC; White IN
Biochem Pharmacol; 1993 Jan; 45(2):321-9. PubMed ID: 7679576
[TBL] [Abstract][Full Text] [Related]
9. Reductive metabolism of 3-amino-1,2,4-benzotriazine-1,4-dioxide (SR 4233) and the induction of unscheduled DNA synthesis in rat and human derived cell lines.
Cahill A; White IN
Carcinogenesis; 1990 Aug; 11(8):1407-11. PubMed ID: 2117504
[TBL] [Abstract][Full Text] [Related]
10. The effect of functional groups on reduction and activation of quinone bioreductive agents by DT-diaphorase.
Fourie J; Oleschuk CJ; Guziec F; Guziec L; Fiterman DJ; Monterrosa C; Begleiter A
Cancer Chemother Pharmacol; 2002 Feb; 49(2):101-10. PubMed ID: 11862423
[TBL] [Abstract][Full Text] [Related]
11. Direct measurement of pO2 distribution and bioreductive enzymes in human malignant brain tumors.
Rampling R; Cruickshank G; Lewis AD; Fitzsimmons SA; Workman P
Int J Radiat Oncol Biol Phys; 1994 Jun; 29(3):427-31. PubMed ID: 8005794
[TBL] [Abstract][Full Text] [Related]
12. Molecular mechanisms of tirapazamine (SR 4233, Win 59075)-induced hepatocyte toxicity under low oxygen concentrations.
Khan S; O'Brien PJ
Br J Cancer; 1995 Apr; 71(4):780-5. PubMed ID: 7710944
[TBL] [Abstract][Full Text] [Related]
13. DT-diaphorase protects cells from the hypoxic cytotoxicity of indoloquinone EO9.
Plumb JA; Gerritsen M; Workman P
Br J Cancer; 1994 Dec; 70(6):1136-43. PubMed ID: 7526885
[TBL] [Abstract][Full Text] [Related]
14. Molecular enzymology of the reductive bioactivation of hypoxic cell cytotoxins.
Walton MI; Wolf CR; Workman P
Int J Radiat Oncol Biol Phys; 1989 Apr; 16(4):983-6. PubMed ID: 2703406
[TBL] [Abstract][Full Text] [Related]
15. Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.
Keyes SR; Fracasso PM; Heimbrook DC; Rockwell S; Sligar SG; Sartorelli AC
Cancer Res; 1984 Dec; 44(12 Pt 1):5638-43. PubMed ID: 6437671
[TBL] [Abstract][Full Text] [Related]
16. Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).
Patterson AV; Barham HM; Chinje EC; Adams GE; Harris AL; Stratford IJ
Br J Cancer; 1995 Nov; 72(5):1144-50. PubMed ID: 7577460
[TBL] [Abstract][Full Text] [Related]
17. Adaptation of human tumor cells to tirapazamine under aerobic conditions: implications of increased antioxidant enzyme activity to mechanism of aerobic cytotoxicity.
Elwell JH; Siim BG; Evans JW; Brown JM
Biochem Pharmacol; 1997 Jul; 54(2):249-57. PubMed ID: 9271329
[TBL] [Abstract][Full Text] [Related]
18. SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures.
Biedermann KA; Wang J; Graham RP; Brown JM
Br J Cancer; 1991 Mar; 63(3):358-62. PubMed ID: 2003976
[TBL] [Abstract][Full Text] [Related]
19. 3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
Fuchs T; Chowdhury G; Barnes CL; Gates KS
J Org Chem; 2001 Jan; 66(1):107-14. PubMed ID: 11429885
[TBL] [Abstract][Full Text] [Related]
20. The role of human and rodent DT-diaphorase in the reductive metabolism of hypoxic cell cytotoxins.
Walton MI; Sugget N; Workman P
Int J Radiat Oncol Biol Phys; 1992; 22(4):643-7. PubMed ID: 1544831
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]