BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

126 related articles for article (PubMed ID: 8441997)

  • 1. Metabolic activation of tris(2,3-dibromopropyl)phosphate to reactive intermediates. I. Covalent binding and reactive metabolite formation in vitro.
    Pearson PG; Omichinski JG; McClanahan RH; Søderlund EJ; Dybing E; Nelson SD
    Toxicol Appl Pharmacol; 1993 Feb; 118(2):186-95. PubMed ID: 8441997
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Metabolic activation of tris(2,3-dibromopropyl)phosphate to reactive intermediates. II. Covalent binding, reactive metabolite formation, and differential metabolite-specific DNA damage in vivo.
    Pearson PG; Omichinski JG; Holme JA; McClanahan RH; Brunborg G; Søderlund EJ; Dybing E; Nelson SD
    Toxicol Appl Pharmacol; 1993 Feb; 118(2):196-204. PubMed ID: 8441998
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Metabolism in vitro of tris(2,3-dibromopropyl)-phosphate: oxidative debromination and bis(2,3-dibromopropyl)phosphate formation as correlates of mutagenicity and covalent protein binding.
    Søderlund EJ; Gordon WP; Nelson SD; Omichinski JG; Dybing E
    Biochem Pharmacol; 1984 Dec; 33(24):4017-23. PubMed ID: 6508849
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Activation mechanism of tris(2,3-dibromopropyl)phosphate to the potent mutagen, 2-bromoacrolein.
    Nelson SD; Omichinski JG; Iyer L; Gordon WP; Soderlund EJ; Dybing E
    Biochem Biophys Res Commun; 1984 May; 121(1):213-9. PubMed ID: 6375666
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Irreversible macromolecular binding of the flame retardant tris-(2, 3-dibromopropyl)phosphate in vitro and in vivo.
    Dybing E; Söderlund EJ; Nelson SD
    Dev Toxicol Environ Sci; 1980; 8():265-8. PubMed ID: 7308025
    [No Abstract]   [Full Text] [Related]  

  • 6. In vitro studies on the metabolic activation of the furanopyridine L-754,394, a highly potent and selective mechanism-based inhibitor of cytochrome P450 3A4.
    Sahali-Sahly Y; Balani SK; Lin JH; Baillie TA
    Chem Res Toxicol; 1996 Sep; 9(6):1007-12. PubMed ID: 8870989
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Metabolic activation of the nitroaromatic antiandrogen flutamide by rat and human cytochromes P-450, including forms belonging to the 3A and 1A subfamilies.
    Berson A; Wolf C; Chachaty C; Fisch C; Fau D; Eugene D; Loeper J; Gauthier JC; Beaune P; Pompon D
    J Pharmacol Exp Ther; 1993 Apr; 265(1):366-72. PubMed ID: 8386241
    [TBL] [Abstract][Full Text] [Related]  

  • 8. NTP technical report on the toxicity and metabolism studies of chloral hydrate (CAS No. 302-17-0). Administered by gavage to F344/N rats and B6C3F1 mice.
    Beland FA
    Toxic Rep Ser; 1999 Aug; (59):1-66, A1-E7. PubMed ID: 11803702
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Imipramine-induced inactivation of a cytochrome P450 2D enzyme in rat liver microsomes: in relation to covalent binding of its reactive intermediate.
    Masubuchi Y; Igarashi S; Suzuki T; Horie T; Narimatsu S
    J Pharmacol Exp Ther; 1996 Nov; 279(2):724-31. PubMed ID: 8930177
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Diester metabolites of the flame retardant chemicals, tris(1,3-dichloro-2-propyl)phosphate and tris(2,3-dibromopropyl) phosphate in the rat: identification and quantification.
    Lynn RK; Wong K; Dickinson RG; Gerber N; Kennish JM
    Res Commun Chem Pathol Pharmacol; 1980 May; 28(2):351-60. PubMed ID: 7394328
    [No Abstract]   [Full Text] [Related]  

  • 11. Mutagenic activation of tris(2,3-dibromopropyl)phosphate: the role of microsomal oxidative metabolism.
    Søderlund EJ; Nelson SD; Dybing E
    Acta Pharmacol Toxicol (Copenh); 1979 Aug; 45(2):112-21. PubMed ID: 40390
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In vitro and in vivo covalent binding of the kidney toxicant and carcinogen tris(2,3-dibromopropyl)-phosphate.
    Söderlund EJ; Nelson SD; Dybing E
    Toxicology; 1981; 21(4):291-304. PubMed ID: 7302950
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Prediction of in vivo potential for metabolic activation of drugs into chemically reactive intermediate: correlation of in vitro and in vivo generation of reactive intermediates and in vitro glutathione conjugate formation in rats and humans.
    Masubuchi N; Makino C; Murayama N
    Chem Res Toxicol; 2007 Mar; 20(3):455-64. PubMed ID: 17309281
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Differences in cytochrome P450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment.
    Hissink AM; Oudshoorn MJ; Van Ommen B; Haenen GR; Van Bladeren PJ
    Chem Res Toxicol; 1996 Dec; 9(8):1249-56. PubMed ID: 8951226
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Comparative genotoxicity studies of the flame retardant tris(2,3-dibromopropyl)phosphate and possible metabolites.
    Holme JA; Søderlund EJ; Hongslo JK; Nelson SD; Dybing E
    Mutat Res; 1983 Dec; 124(3-4):213-24. PubMed ID: 6686285
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Bioactivation of coumarin in rat olfactory mucosal microsomes: Detection of protein covalent binding and identification of reactive intermediates through analysis of glutathione adducts.
    Zhuo X; Zhao W; Zheng J; Humphreys WG; Shu YZ; Zhu M
    Chem Biol Interact; 2009 Oct; 181(2):227-35. PubMed ID: 19576871
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Lack of mammalian mutagenicity of the potent bacterial mutagen tris(2,3-dibromopropyl) phosphate and its metabolite 2-bromoacrolein.
    van Beerendonk GJ; Klein JC; Tijdens RB; Lichtenauer-Kaligis EG; Tasseron-de Jong JG; Meerman JH
    Mutat Res; 1998 Jul; 415(3):201-11. PubMed ID: 9714806
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Bioactivation of phenytoin by human cytochrome P450: characterization of the mechanism and targets of covalent adduct formation.
    Munns AJ; De Voss JJ; Hooper WD; Dickinson RG; Gillam EM
    Chem Res Toxicol; 1997 Sep; 10(9):1049-58. PubMed ID: 9305589
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Disposition of the flame retardant, tris(1,3-dichloro-2-propyl) phosphate, in the rat.
    Lynn RK; Wong K; Garvie-Gould C; Kennish JM
    Drug Metab Dispos; 1981; 9(5):434-41. PubMed ID: 6117442
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Metabolism of the cytochrome P450 mechanism-based inhibitor N-benzyl-1-aminobenzotriazole to products that covalently bind with protein in guinea pig liver and lung microsomes: comparative study with 1-aminobenzotriazole.
    Woodcroft KJ; Webb CD; Yao M; Weedon AC; Bend JR
    Chem Res Toxicol; 1997 May; 10(5):589-99. PubMed ID: 9168258
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.