BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

361 related articles for article (PubMed ID: 8454854)

  • 1. Recombinant immunotoxins containing the VH or VL domain of monoclonal antibody B3 fused to Pseudomonas exotoxin.
    Brinkmann U; Lee BK; Pastan I
    J Immunol; 1993 Apr; 150(7):2774-82. PubMed ID: 8454854
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Rapid humanization of the Fv of monoclonal antibody B3 by using framework exchange of the recombinant immunotoxin B3(Fv)-PE38.
    Benhar I; Padlan EA; Jung SH; Lee B; Pastan I
    Proc Natl Acad Sci U S A; 1994 Dec; 91(25):12051-5. PubMed ID: 7991583
    [TBL] [Abstract][Full Text] [Related]  

  • 3. A recombinant immunotoxin that is active on prostate cancer cells and that is composed of the Fv region of monoclonal antibody PR1 and a truncated form of Pseudomonas exotoxin.
    Brinkmann U; Gallo M; Brinkmann E; Kunwar S; Pastan I
    Proc Natl Acad Sci U S A; 1993 Jan; 90(2):547-51. PubMed ID: 8421689
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Identification of residues that stabilize the single-chain Fv of monoclonal antibodies B3.
    Benhar I; Pastan I
    J Biol Chem; 1995 Oct; 270(40):23373-80. PubMed ID: 7559495
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Engineering interchain disulfide bonds into conserved framework regions of Fv fragments: improved biochemical characteristics of recombinant immunotoxins containing disulfide-stabilized Fv.
    Reiter Y; Brinkmann U; Webber KO; Jung SH; Lee B; Pastan I
    Protein Eng; 1994 May; 7(5):697-704. PubMed ID: 8073039
    [TBL] [Abstract][Full Text] [Related]  

  • 6. B3(Fv)-PE38KDEL, a single-chain immunotoxin that causes complete regression of a human carcinoma in mice.
    Brinkmann U; Pai LH; FitzGerald DJ; Willingham M; Pastan I
    Proc Natl Acad Sci U S A; 1991 Oct; 88(19):8616-20. PubMed ID: 1924323
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Stabilization of the Fv fragments in recombinant immunotoxins by disulfide bonds engineered into conserved framework regions.
    Reiter Y; Brinkmann U; Kreitman RJ; Jung SH; Lee B; Pastan I
    Biochemistry; 1994 May; 33(18):5451-9. PubMed ID: 7910034
    [TBL] [Abstract][Full Text] [Related]  

  • 8. B3(Fab)-PE38M: a recombinant immunotoxin in which a mutant form of Pseudomonas exotoxin is fused to the Fab fragment of monoclonal antibody B3.
    Choe M; Webber KO; Pastan I
    Cancer Res; 1994 Jul; 54(13):3460-7. PubMed ID: 8012967
    [TBL] [Abstract][Full Text] [Related]  

  • 9. A method for increasing the yield of properly folded recombinant fusion proteins: single-chain immunotoxins from renaturation of bacterial inclusion bodies.
    Buchner J; Pastan I; Brinkmann U
    Anal Biochem; 1992 Sep; 205(2):263-70. PubMed ID: 1332541
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Activity of a single-chain immunotoxin that selectively kills lymphoma and other B-lineage cells expressing the CD40 antigen.
    Francisco JA; Gilliland LK; Stebbins MR; Norris NA; Ledbetter JA; Siegall CB
    Cancer Res; 1995 Jul; 55(14):3099-104. PubMed ID: 7541711
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Independent domain folding of Pseudomonas exotoxin and single-chain immunotoxins: influence of interdomain connections.
    Brinkmann U; Buchner J; Pastan I
    Proc Natl Acad Sci U S A; 1992 Apr; 89(7):3075-9. PubMed ID: 1557415
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Cloning, expression and characterization of the Fv fragments of the anti-carbohydrate mAbs B1 and B5 as single-chain immunotoxins.
    Benhar I; Pastan I
    Protein Eng; 1994 Dec; 7(12):1509-15. PubMed ID: 7716163
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A recombinant immunotoxin containing a disulfide-stabilized Fv fragment.
    Brinkmann U; Reiter Y; Jung SH; Lee B; Pastan I
    Proc Natl Acad Sci U S A; 1993 Aug; 90(16):7538-42. PubMed ID: 8356052
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Cytotoxic and antitumor activity of a recombinant immunotoxin composed of disulfide-stabilized anti-Tac Fv fragment and truncated Pseudomonas exotoxin.
    Reiter Y; Kreitman RJ; Brinkmann U; Pastan I
    Int J Cancer; 1994 Jul; 58(1):142-9. PubMed ID: 8014011
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: relative importance of the two toxin disulfide bonds.
    Kreitman RJ; Batra JK; Seetharam S; Chaudhary VK; FitzGerald DJ; Pastan I
    Bioconjug Chem; 1993; 4(2):112-20. PubMed ID: 7873642
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A recombinant immunotoxin consisting of two antibody variable domains fused to Pseudomonas exotoxin.
    Chaudhary VK; Queen C; Junghans RP; Waldmann TA; FitzGerald DJ; Pastan I
    Nature; 1989 Jun; 339(6223):394-7. PubMed ID: 2498664
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Design of interchain disulfide bonds in the framework region of the Fv fragment of the monoclonal antibody B3.
    Jung SH; Pastan I; Lee B
    Proteins; 1994 May; 19(1):35-47. PubMed ID: 8066084
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment.
    Reiter Y; Brinkmann U; Jung SH; Lee B; Kasprzyk PG; King CR; Pastan I
    J Biol Chem; 1994 Jul; 269(28):18327-31. PubMed ID: 7913461
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Recombinant immunotoxin containing a disulfide-stabilized Fv directed at erbB2 that does not require proteolytic activation.
    Kuan CT; Pastan I
    Biochemistry; 1996 Mar; 35(9):2872-7. PubMed ID: 8608123
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Recombinant single-chain and disulfide-stabilized Fv-immunotoxins that cause complete regression of a human colon cancer xenograft in nude mice.
    Reiter Y; Wright AF; Tonge DW; Pastan I
    Int J Cancer; 1996 Jul; 67(1):113-23. PubMed ID: 8690511
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 19.