259 related articles for article (PubMed ID: 8461045)
1. Isolation and characterization of a human ileocecal carcinoma cell line (HCT-8) subclone resistant to fluorodeoxyuridine.
Zhang ZG; Malmberg M; Yin MB; Slocum HK; Rustum YM
Biochem Pharmacol; 1993 Mar; 45(5):1157-64. PubMed ID: 8461045
[TBL] [Abstract][Full Text] [Related]
2. Mechanisms of resistance to fluoropyrimidines.
Zhang ZG; Harstrick A; Rustum YM
Semin Oncol; 1992 Apr; 19(2 Suppl 3):4-9. PubMed ID: 1532673
[TBL] [Abstract][Full Text] [Related]
3. Time dependence of DNA lesions and growth inhibition by ICI D1694, a new quinazoline antifolate thymidylate synthase inhibitor.
Yin MB; Guimaraes MA; Zhang ZG; Arredondo MA; Rustum YM
Cancer Res; 1992 Nov; 52(21):5900-5. PubMed ID: 1394217
[TBL] [Abstract][Full Text] [Related]
4. Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
Jackman AL; Alison DL; Calvert AH; Harrap KR
Cancer Res; 1986 Jun; 46(6):2810-5. PubMed ID: 2938731
[TBL] [Abstract][Full Text] [Related]
5. 5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase.
Chong LK; Tattersall MH
Biochem Pharmacol; 1995 Mar; 49(6):819-27. PubMed ID: 7702640
[TBL] [Abstract][Full Text] [Related]
6. Mechanisms of acquired resistance to modulation of 5-fluorouracil by leucovorin in HCT-8 human ileocecal carcinoma cells.
Lu K; McGuire JJ; Slocum HK; Rustum YM
Biochem Pharmacol; 1997 Mar; 53(5):689-96. PubMed ID: 9113088
[TBL] [Abstract][Full Text] [Related]
7. Resistance of CCRF-CEM cloned sublines to 5-fluorodeoxyuridine associated with enhanced phosphatase activities.
Fernandes DJ; Cranford SK
Biochem Pharmacol; 1985 Jan; 34(1):125-32. PubMed ID: 3155614
[TBL] [Abstract][Full Text] [Related]
8. Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen.
Grem JL; Danenberg KD; Behan K; Parr A; Young L; Danenberg PV; Nguyen D; Drake J; Monks A; Allegra CJ
Clin Cancer Res; 2001 Apr; 7(4):999-1009. PubMed ID: 11309351
[TBL] [Abstract][Full Text] [Related]
9. Defective facilitated diffusion of nucleosides, a primary mechanism of resistance to 5-fluoro-2'-deoxyuridine in the HCT-8 human carcinoma line.
Sobrero AF; Moir RD; Bertino JR; Handschumacher RE
Cancer Res; 1985 Jul; 45(7):3155-60. PubMed ID: 3159474
[TBL] [Abstract][Full Text] [Related]
10. Resistance to 5-fluorouracil and 5-fluoro-2'-deoxyuridine mechanisms and clinical implications.
Sobrero A; Aschele C; Guglielmi A; Nobile MT; Rosso R
J Chemother; 1990 Feb; 2 Suppl 1():12-6. PubMed ID: 2142213
[TBL] [Abstract][Full Text] [Related]
11. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
Jackman AL; Taylor GA; Gibson W; Kimbell R; Brown M; Calvert AH; Judson IR; Hughes LR
Cancer Res; 1991 Oct; 51(20):5579-86. PubMed ID: 1913676
[TBL] [Abstract][Full Text] [Related]
12. Alteration of fluorouracil metabolism in human colon cancer cells by dipyridamole with a selective increase in fluorodeoxyuridine monophosphate levels.
Grem JL; Fischer PH
Cancer Res; 1986 Dec; 46(12 Pt 1):6191-9. PubMed ID: 2946402
[TBL] [Abstract][Full Text] [Related]
13. Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.
Aschele C; Sobrero A; Faderan MA; Bertino JR
Cancer Res; 1992 Apr; 52(7):1855-64. PubMed ID: 1532346
[TBL] [Abstract][Full Text] [Related]
14. Genetic variation in thymidylate synthase confers resistance to 5-fluorodeoxyuridine.
Hughey CT; Barbour KW; Berger FG; Berger SH
Adv Exp Med Biol; 1993; 339():67-76. PubMed ID: 8178730
[TBL] [Abstract][Full Text] [Related]
15. Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line.
Lu K; Yin MB; McGuire JJ; Bonmassar E; Rustum YM
Biochem Pharmacol; 1995 Jul; 50(3):391-8. PubMed ID: 7646540
[TBL] [Abstract][Full Text] [Related]
16. Variation in human thymidylate synthase is associated with resistance to 5-fluoro-2'-deoxyuridine.
Davis ST; Berger SH
Mol Pharmacol; 1993 May; 43(5):702-8. PubMed ID: 8502227
[TBL] [Abstract][Full Text] [Related]
17. Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells.
Murakami Y; Kazuno H; Emura T; Tsujimoto H; Suzuki N; Fukushima M
Int J Oncol; 2000 Aug; 17(2):277-83. PubMed ID: 10891536
[TBL] [Abstract][Full Text] [Related]
18. Determinants of cytotoxicity with prolonged exposure to fluorouracil in human colon cancer cells.
Ren Q; Van Groeningen CJ; Hardcastle A; Aherne GW; Geoffroy F; Allegra CJ; Johnston PG; Grem JL
Oncol Res; 1997; 9(2):77-88. PubMed ID: 9167189
[TBL] [Abstract][Full Text] [Related]
19. Clinical pharmacological studies of concurrent infusion of 5-fluorouracil and thymidine in treatment of colorectal carcinomas.
Au JL; Rustum YM; Ledesma EJ; Mittelman A; Creaven PJ
Cancer Res; 1982 Jul; 42(7):2930-7. PubMed ID: 6211226
[TBL] [Abstract][Full Text] [Related]
20. Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.
Bapat AR; Zarow C; Danenberg PV
J Biol Chem; 1983 Apr; 258(7):4130-6. PubMed ID: 6220000
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]