These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

106 related articles for article (PubMed ID: 8478908)

  • 1. Inhibitors of the protease from human immunodeficiency virus: synthesis, enzyme inhibition, and antiviral activity of a series of compounds containing the dihydroxyethylene transition-state isostere.
    Thaisrivongs S; Turner SR; Strohbach JW; TenBrink RE; Tarpley WG; McQuade TJ; Heinrikson RL; Tomasselli AG; Hui JO; Howe WJ
    J Med Chem; 1993 Apr; 36(8):941-52. PubMed ID: 8478908
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Hydroxyethylene isostere inhibitors of human immunodeficiency virus-1 protease: structure-activity analysis using enzyme kinetics, X-ray crystallography, and infected T-cell assays.
    Dreyer GB; Lambert DM; Meek TD; Carr TJ; Tomaszek TA; Fernandez AV; Bartus H; Cacciavillani E; Hassell AM; Minnich M
    Biochemistry; 1992 Jul; 31(29):6646-59. PubMed ID: 1637805
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design and synthesis of substrate-based peptidomimetic human immunodeficiency virus protease inhibitors containing the hydroxymethylcarbonyl isostere.
    Kiso Y
    Biopolymers; 1996; 40(2):235-44. PubMed ID: 8785365
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Inhibitors of the protease from human immunodeficiency virus: design and modeling of a compound containing a dihydroxyethylene isostere insert with high binding affinity and effective antiviral activity.
    Thaisrivongs S; Tomasselli AG; Moon JB; Hui J; McQuade TJ; Turner SR; Strohbach JW; Howe WJ; Tarpley WG; Heinrikson RL
    J Med Chem; 1991 Aug; 34(8):2344-56. PubMed ID: 1875334
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and structure-activity relationships of a series of penicillin-derived HIV proteinase inhibitors containing a stereochemically unique peptide isostere.
    Holmes DS; Bethell RC; Cammack N; Clemens IR; Kitchin J; McMeekin P; Mo CL; Orr DC; Patel B; Paternoster IL
    J Med Chem; 1993 Oct; 36(21):3129-36. PubMed ID: 8230099
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A series of potent HIV-1 protease inhibitors containing a hydroxyethyl secondary amine transition state isostere: synthesis, enzyme inhibition, and antiviral activity.
    Tucker TJ; Lumma WC; Payne LS; Wai JM; de Solms SJ; Giuliani EA; Darke PL; Heimbach JC; Zugay JA; Schleif WA
    J Med Chem; 1992 Jul; 35(14):2525-33. PubMed ID: 1635054
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Crystal structure of a complex of HIV-1 protease with a dihydroxyethylene-containing inhibitor: comparisons with molecular modeling.
    Thanki N; Rao JK; Foundling SI; Howe WJ; Moon JB; Hui JO; Tomasselli AG; Heinrikson RL; Thaisrivongs S; Wlodawer A
    Protein Sci; 1992 Aug; 1(8):1061-72. PubMed ID: 1304383
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Three-dimensional QSAR of human immunodeficiency virus (I) protease inhibitors. 1. A CoMFA study employing experimentally-determined alignment rules.
    Waller CL; Oprea TI; Giolitti A; Marshall GR
    J Med Chem; 1993 Dec; 36(26):4152-60. PubMed ID: 8277496
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Aza-peptide analogs as potent human immunodeficiency virus type-1 protease inhibitors with oral bioavailability.
    Fässler A; Bold G; Capraro HG; Cozens R; Mestan J; Poncioni B; Rösel J; Tintelnot-Blomley M; Lang M
    J Med Chem; 1996 Aug; 39(16):3203-16. PubMed ID: 8759643
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance.
    Ghosh AK; Chapsal BD; Weber IT; Mitsuya H
    Acc Chem Res; 2008 Jan; 41(1):78-86. PubMed ID: 17722874
    [TBL] [Abstract][Full Text] [Related]  

  • 11. HIV-1 protease inhibitors with a transition-state mimic comprising a tertiary alcohol: improved antiviral activity in cells.
    Mahalingam AK; Axelsson L; Ekegren JK; Wannberg J; Kihlström J; Unge T; Wallberg H; Samuelsson B; Larhed M; Hallberg A
    J Med Chem; 2010 Jan; 53(2):607-15. PubMed ID: 19961222
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structure-based design of novel HIV protease inhibitors: sulfonamide-containing 4-hydroxycoumarins and 4-hydroxy-2-pyrones as potent non-peptidic inhibitors.
    Thaisrivongs S; Janakiraman MN; Chong KT; Tomich PK; Dolak LA; Turner SR; Strohbach JW; Lynn JC; Horng MM; Hinshaw RR; Watenpaugh KD
    J Med Chem; 1996 Jun; 39(12):2400-10. PubMed ID: 8691434
    [TBL] [Abstract][Full Text] [Related]  

  • 13. HIV-1 protease inhibitors: ketomethylene isosteres with unusually high affinity compared with hydroxyethylene isostere analogs.
    Marinier A; Toth MV; Houseman K; Mueller R; Marshall GR
    Bioorg Med Chem; 1994 Sep; 2(9):919-25. PubMed ID: 7712127
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: modifications of the P1/P1' residues.
    Patel M; Bacheler LT; Rayner MM; Cordova BC; Klabe RM; Erickson-Viitanen S; Seitz SP
    Bioorg Med Chem Lett; 1998 Apr; 8(7):823-8. PubMed ID: 9871548
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors.
    Dorsey BD; McDonough C; McDaniel SL; Levin RB; Newton CL; Hoffman JM; Darke PL; Zugay-Murphy JA; Emini EA; Schleif WA; Olsen DB; Stahlhut MW; Rutkowski CA; Kuo LC; Lin JH; Chen IW; Michelson SR; Holloway MK; Huff JR; Vacca JP
    J Med Chem; 2000 Sep; 43(18):3386-99. PubMed ID: 10978186
    [TBL] [Abstract][Full Text] [Related]  

  • 16. HIV-1 protease inhibitors based on hydroxyethylene dipeptide isosteres: an investigation into the role of the P1' side chain on structure-activity.
    Young SD; Payne LS; Thompson WJ; Gaffin N; Lyle TA; Britcher SF; Graham SL; Schultz TH; Deana AA; Darke PL
    J Med Chem; 1992 May; 35(10):1702-9. PubMed ID: 1588552
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Antiretroviral agents as inhibitors of both human immunodeficiency virus type 1 integrase and protease.
    Mazumder A; Wang S; Neamati N; Nicklaus M; Sunder S; Chen J; Milne GW; Rice WG; Burke TR; Pommier Y
    J Med Chem; 1996 Jun; 39(13):2472-81. PubMed ID: 8691444
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Bis tertiary amide inhibitors of the HIV-1 protease generated via protein structure-based iterative design.
    Melnick M; Reich SH; Lewis KK; Mitchell LJ; Nguyen D; Trippe AJ; Dawson H; Davies JF; Appelt K; Wu BW; Musick L; Gehlhaar DK; Webber S; Shetty B; Kosa M; Kahil D; Andrada D
    J Med Chem; 1996 Jul; 39(14):2795-811. PubMed ID: 8709110
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Small dipeptide-based HIV protease inhibitors containing the hydroxymethylcarbonyl isostere as an ideal transition-state mimic.
    Kiso Y; Matsumoto H; Mizumoto S; Kimura T; Fujiwara Y; Akaji K
    Biopolymers; 1999; 51(1):59-68. PubMed ID: 10380353
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Configurations of diastereomeric hydroxyethylene isosteres strongly affect biological activities of a series of specific inhibitors of human-immunodeficiency-virus proteinase.
    Konvalinka J; Litera J; Weber J; Vondrásek J; Hradílek M; Soucek M; Pichová I; Majer P; Strop P; Sedlácek J; Heuser AM; Kottler H; Kräusslich HG
    Eur J Biochem; 1997 Dec; 250(2):559-66. PubMed ID: 9428710
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.