These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
2. The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1. Rozakis-Adcock M; Fernley R; Wade J; Pawson T; Bowtell D Nature; 1993 May; 363(6424):83-5. PubMed ID: 8479540 [TBL] [Abstract][Full Text] [Related]
3. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras. Gale NW; Kaplan S; Lowenstein EJ; Schlessinger J; Bar-Sagi D Nature; 1993 May; 363(6424):88-92. PubMed ID: 8386805 [TBL] [Abstract][Full Text] [Related]
4. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Egan SE; Giddings BW; Brooks MW; Buday L; Sizeland AM; Weinberg RA Nature; 1993 May; 363(6424):45-51. PubMed ID: 8479536 [TBL] [Abstract][Full Text] [Related]
5. Coupling of the murine protein tyrosine phosphatase PEST to the epidermal growth factor (EGF) receptor through a Src homology 3 (SH3) domain-mediated association with Grb2. Charest A; Wagner J; Kwan M; Tremblay ML Oncogene; 1997 Apr; 14(14):1643-51. PubMed ID: 9135065 [TBL] [Abstract][Full Text] [Related]
6. A Grb2-associated docking protein in EGF- and insulin-receptor signalling. Holgado-Madruga M; Emlet DR; Moscatello DK; Godwin AK; Wong AJ Nature; 1996 Feb; 379(6565):560-4. PubMed ID: 8596638 [TBL] [Abstract][Full Text] [Related]
7. Grb2 regulates Stat3 activation negatively in epidermal growth factor signalling. Zhang T; Ma J; Cao X Biochem J; 2003 Dec; 376(Pt 2):457-64. PubMed ID: 14498832 [TBL] [Abstract][Full Text] [Related]
8. Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins. Li N; Schlessinger J; Margolis B Oncogene; 1994 Dec; 9(12):3457-65. PubMed ID: 7970705 [TBL] [Abstract][Full Text] [Related]
9. Sos1 rapidly associates with Grb2 and is hypophosphorylated when complexed with the EGF receptor after EGF stimulation. Hu Y; Bowtell DD Oncogene; 1996 May; 12(9):1865-72. PubMed ID: 8649846 [TBL] [Abstract][Full Text] [Related]
10. Phosphorylation of growth factor receptor binding protein-2 by pp60c-src tyrosine kinase. Jones DA; Benjamin CW Arch Biochem Biophys; 1997 Jan; 337(2):143-8. PubMed ID: 9016807 [TBL] [Abstract][Full Text] [Related]
11. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Rozakis-Adcock M; McGlade J; Mbamalu G; Pelicci G; Daly R; Li W; Batzer A; Thomas S; Brugge J; Pelicci PG; Schlessinger J; Pawson T Nature; 1992 Dec; 360(6405):689-92. PubMed ID: 1465135 [TBL] [Abstract][Full Text] [Related]
12. Grb2 regulation of the actin-based cytoskeleton is required for ligand-independent EGF receptor-mediated oncogenesis. Boerner JL; Danielsen AJ; Lovejoy CA; Wang Z; Juneja SC; Faupel-Badger JM; Darce JR; Maihle NJ Oncogene; 2003 Oct; 22(43):6679-89. PubMed ID: 14555981 [TBL] [Abstract][Full Text] [Related]
13. Activation of tyrosine kinases by alpha1A-adrenergic and growth factor receptors in transfected PC12 cells. Zhong H; Minneman KP Biochem J; 1999 Dec; 344 Pt 3(Pt 3):889-94. PubMed ID: 10585878 [TBL] [Abstract][Full Text] [Related]
14. Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2. Janes PW; Daly RJ; deFazio A; Sutherland RL Oncogene; 1994 Dec; 9(12):3601-8. PubMed ID: 7970720 [TBL] [Abstract][Full Text] [Related]
15. N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway. Nakamura T; Sanokawa R; Sasaki Y; Ayusawa D; Oishi M; Mori N Oncogene; 1996 Sep; 13(6):1111-21. PubMed ID: 8808684 [TBL] [Abstract][Full Text] [Related]
16. Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. Nioche P; Liu WQ; Broutin I; Charbonnier F; Latreille MT; Vidal M; Roques B; Garbay C; Ducruix A J Mol Biol; 2002 Feb; 315(5):1167-77. PubMed ID: 11827484 [TBL] [Abstract][Full Text] [Related]
17. A new function for phospholipase C-gamma1: coupling to the adaptor protein GRB2. Pei Z; Maloney JA; Yang L; Williamson JR Arch Biochem Biophys; 1997 Sep; 345(1):103-10. PubMed ID: 9281317 [TBL] [Abstract][Full Text] [Related]
18. SH2 domain specificity and activity modified by a single residue. Marengere LE; Songyang Z; Gish GD; Schaller MD; Parsons JT; Stern MJ; Cantley LC; Pawson T Nature; 1994 Jun; 369(6480):502-5. PubMed ID: 7515480 [TBL] [Abstract][Full Text] [Related]
19. Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals. Shou C; Wurmser A; Suen KL; Barbacid M; Feig LA; Ling K Oncogene; 1995 May; 10(10):1887-93. PubMed ID: 7761090 [TBL] [Abstract][Full Text] [Related]